全文获取类型
收费全文 | 331篇 |
免费 | 11篇 |
专业分类
儿科学 | 46篇 |
基础医学 | 15篇 |
口腔科学 | 4篇 |
临床医学 | 35篇 |
内科学 | 89篇 |
皮肤病学 | 10篇 |
神经病学 | 25篇 |
外科学 | 60篇 |
综合类 | 2篇 |
预防医学 | 3篇 |
眼科学 | 1篇 |
药学 | 35篇 |
肿瘤学 | 17篇 |
出版年
2017年 | 3篇 |
2016年 | 5篇 |
2015年 | 6篇 |
2014年 | 2篇 |
2013年 | 6篇 |
2012年 | 2篇 |
2010年 | 8篇 |
2009年 | 14篇 |
2008年 | 1篇 |
2007年 | 5篇 |
2006年 | 29篇 |
2005年 | 14篇 |
2004年 | 8篇 |
2003年 | 11篇 |
2002年 | 9篇 |
2001年 | 3篇 |
1999年 | 8篇 |
1998年 | 35篇 |
1997年 | 31篇 |
1996年 | 30篇 |
1995年 | 19篇 |
1994年 | 8篇 |
1993年 | 15篇 |
1992年 | 8篇 |
1991年 | 3篇 |
1990年 | 5篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1987年 | 2篇 |
1986年 | 4篇 |
1985年 | 2篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1978年 | 5篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1969年 | 1篇 |
1968年 | 2篇 |
1958年 | 1篇 |
1957年 | 2篇 |
1956年 | 2篇 |
1955年 | 4篇 |
1954年 | 6篇 |
1949年 | 1篇 |
排序方式: 共有342条查询结果,搜索用时 15 毫秒
21.
Separation of the polypeptide chains of hemoglobin and identification ofan abnormal chain may be achieved in a few hours by electrophoresis oncellulose acetate in barbital buffer pH 8.6, with 6 M urea. The method isapplicable to whole hemolysates to which a large amount of 2-mercaptoethanolhas been added. It requires minimal preparative work. Submitted on January 7, 1969 Accepted on April 17, 1969 相似文献
22.
The distribution of Leu-7 antigen was investigated using immunoperoxidase staining technique. It was found that HNK-I monoclonal antibody reacted with peripheral nerves and sweat glands (both apocrine and eccrine) of the skin. HNK-I antibody is a new marker for them, and may help to elucidate the nature of some skin tumours. 相似文献
23.
Sympathetic skin response in diabetic children: Do diabetic children have diabetic neuropathy? 总被引:3,自引:0,他引:3
KATSUMI Torigoe OSAMU Numata SATOSHI Yazaki SATOSHI Hasegawa NAOKI Boku MAKOTO Hiura HARUYOSHI Ino & MASAMICHI Matsunaga 《Pediatrics international》1999,41(6):631-636
BACKGROUND: Abnormal sympathetic skin response (SSR) has been reported in adult patients with diabetic neuropathy. In addition, other studies have revealed abnormal SSR in diabetic patients not having autonomic symptoms and autonomic dysfunctions. These findings have been only obtained from adult patients. There have been few reports on the autonomic functions in diabetic children. Accordingly, it is not clear whether the autonomic neuropathy occurs in diabetic children. The aim of the present study is to clear autonomic function in children with insulin-dependent diabetes mellitus by SSR. METHODS: The SSR was measured in 28 normal healthy children and in eight patients with IDDM not having symptoms of dysautonomia. The SSR was elicited using 10 stimuli on programmed Nihonkoden Neuropack Sigma model machine. Following a single electrical stimulation, four SSR were recorded in both the palms and the soles simultaneously. RESULTS: The SSR were simultaneously obtained in 100% of the two groups. The amplitudes in the palms and soles were not significantly different between the two groups. The mean and shortest latency in the soles were significantly longer in the IDDM group than in the control group (P < 0.01). None of the measurements of SSR revealed correlation with duration of diabetes and onset of illness. CONCLUSIONS: Diabetic neuropathy may not have occurred in young patients having shorter duration of illness. Conversely, assuming that prolonged latency is abnormal, it may even have occurred in them. Follow up on these patients with prolonged latencies would be required. 相似文献
24.
IZAURA Y. HIRATA PAULO BOSCHCOV MARIA C.F. OLIVEIRA MARIA APARECIDA JULIANO ANTONIO MIRANDA JAIR R. CHAGAS SATOSHI TSUBOI YOSHIO OKADA LUIZ JULIANO 《Chemical biology & drug design》1991,38(4):298-307
The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin. The synthesis was performed by fragment condensation using the Honzl and Rudinger azide procedure. In our conditions for azide segment condensation, histidine racemization was demonstrated to be negligible for most of the condensation reactions. Human renin liberates angiotensin I from h-angiotensinogen (1-17)-NH2 with a Km value of 3.4 × 10?5m , at pH 7.3 and 37° being similar to h-angiotensinogen (1-13), an analog without the carbohydrate binding site. However, the Vmax value of 4.1 × 10?9mol/G.U. min is one order of magnitude higher. Porcine pepsin was demonstrated to cleave preferentially Leu10-Val11 bond and, surprisingly, His9-Leu10 as well. 相似文献
25.
YUTARO HAYASHI YOSHIYUKI KOJIMA KENTARO MIZUNO AKIHIRO NAKANE SATOSHI KUROKAWA KENJIRO KOHRI 《International journal of urology》2005,12(2):234-238
The adequate correction of penile curvature is essential for successful hypospadias surgery. We describe a novel technique to correct severe penile curvature with a tunica vaginalis flap on the penile ventrum. We applied a tunica vaginalis flap to lengthen the ventral aspect of the tunica albuginea in two boys with significant curvature and proximal hypospadias. Tunica vaginalis flap patching to the ventral aspect of the penis is safe and technically feasible. If penile curvature is severe or the penis is small in hypospadiac patients, lengthening the ventral aspect using a tunica vaginalis flap is likely to expand instead of dorsal plication or ventral graft. 相似文献
26.
MASAOMI CHINUSHI YOSHIFUSA AIZAWA KOUJI OHHIRA SATOSHI FUJITA MASAMI SHIBA SHINICHI NIWANO HIROSHI FURUSHIMA 《Pacing and clinical electrophysiology : PACE》1998,21(4):669-678
In 23 consecutive patients, radiofrequency (RF) ablation was used as treatment for idiopathic ventricular tachycardia (VT) originating from the outflow tract of the right ventricle. In this study, we focused on the repetitive ventricular response (> 5 consecutive QRS beats during RF application). The incidence and clinical implications of the repetitive ventricular response were examined through the results of endocardial mapping and RF ablation. VT origin was mapped as the earliest activation site during VT, and it was determined within 0.5 × 0.5 cm (narrow site) in 13 patients and wider than 0.5 × 0.5 cm (wide origin) in the other 10 patients. The repetitive ventricular response was induced during application of RF current in 14 of 23 patients (61%), and it was more frequently observed in VT from a wide origin (100%) than in the VT from a narrow site (31%). The QRS morphology of the repetitive ventricular response was identical to that of clinical VT. As RF application was continued and/or repeated, the RR interval of the repetitive ventricular response was gradually prolonged, the number of consecutive QRS complexes was decreased, and clinical VT was finally eliminated. The overall success rate of RF ablation was 96% (22/23 patients), and no complications were observed. In conclusion, a repetitive ventricular response was frequently observed in idiopathic right VT. The changing pattern of repetitive ventricular response, slowing, and/or disappearing was consistent with successful RF ablation. 相似文献
27.
Published:年月日 《中国血液净化》2002,1(9):3-4
We have previously reported that the diameter of the inferior vena cava(IVC) reflects the amount of body fluid in hemodialyzed (HD) patients. The present study was undertaken to depict the criteria of IVC diameters for determining dry weight (DW) in anuric HD patients. In healthy subjects, the maximal diameters during quiet expiration (IVCe) and the minimal diameters during quiet inspiration (IVCi) were (16.7±3.2) and (5.7±5.4)mm,respectively (mean±SD).The collapsibility index (CI,1-IVCi/IVCe), which inversely correlates with the central venous pressure,was 0.68±0.29. In anuric HD patients,the IVCe/CI values before and after HD were 14.9±3.2/0.68±0.24 and 8.2±2.3/0.94±0.09, respectively. IVCe decreased proportionally to the amount of ultrafiltration. In HD patients with hypervolemic pulmonary edema, the IVCe and CI values were 22.4±2.9 and 0.22±0.11, respectively. We proposed that IVCe/CI after HD is (8±3)mm/0.9 ± 0.1 as the markers of DW in anuric HD patients and that an IVCe value≥22mm together with a CI≤0.22 implies the warning level of body fluid retention. 相似文献
28.
An ECG Index of P‐Wave Force Predicts the Recurrence of Atrial Fibrillation after Pulmonary Vein Isolation 下载免费PDF全文
YASUNORI KANZAKI M.D. YASUYA INDEN M.D. Ph.D. MONAMI ANDO M.D. YOSUKE KAMIKUBO M.D. TADAHIRO ITO M.D. YOSHIAKI MIZUTANI M.D. HIROYUKI KATO M.D. AYA FUJII M.D. SATOSHI YANAGISAWA M.D. MAKOTO HIRAI M.D. Ph.D. TOYOAKI MUROHARA M.D. Ph.D. 《Pacing and clinical electrophysiology : PACE》2016,39(11):1191-1197
29.
LI‐WEI LO M.D. SATOSHI HIGA M.D. Ph.D. YENN‐JIANG LIN M.D. SHIH‐LIN CHANG M.D. TA‐CHUAN TUAN M.D. YU‐FENG HU M.D. WEN‐CHIN TSAI M.D. HSUAN‐MING TSAO M.D. CHING‐TAI TAI M.D. SUGAKO ISHIGAKI M.D. ASUKA OYAKAWA M.D. MINETAKA MAEDA M.D. KAZUYOSHI SUENARI M.D. SHIH‐ANN CHEN M.D. 《Journal of cardiovascular electrophysiology》2010,21(6):640-648
Unipolar Characteristics of CFAEs. Background: The noncontact mapping (NCM) system possesses the merit of global endocardial recording for unipolar and activation mapping. Objective: We aimed to evaluate the unipolar electrogram characteristics and activation pattern over the bipolar complex fractionated atrial electrogram (CFAE) sites during atrial fibrillation (AF). Methods: Twenty patients (age 55 ± 11 years old, 15 males) who underwent NCM and ablation of AF (paroxysmal/persistent = 13/7) were included. Both contact bipolar (32–300 Hz) and NCM virtual unipolar electrograms (0.5–300 Hz) were simultaneously recorded along with the activation pattern (total 223 sites, 11 ± 4 sites/patient). A CFAE was defined as a mean bipolar cycle length of ≤ 120 ms with an intervening isoelectric interval of more than 50 ms (Group 1A, n = 63, rapid repetitive CFAEs) or continuous fractionated activity (Group 1B, n = 59, continuous fractionated CFAEs), measured over a 7.2‐second duration. Group 2 consisted of those with a bipolar cycle length of more than 120 ms (n = 101). Results: The Group 1A CFAE sites exhibited a shorter unipolar electrogram cycle length (129 ± 11 vs 164 ± 20 ms, P < 0.001), and higher percentage of an S‐wave predominant pattern (QS or rS wave, 63 ± 13% vs 35 ± 13%, P < 0.001) than the Group 2 non‐CFAE sites. There was a linear correlation between the bipolar and unipolar cycle lengths (P < 0.001, R = 0.87). Most of the Group 1A CFAEs were located over arrhythmogenic pulmonary vein ostia or nonpulmonary vein ectopy with repetitive activations from those ectopies (62%) or the pivot points of the turning wavefronts (21%), whereas the Group 1B CFAEs exhibited a passive activation (44%) or slow conduction (31%). Conclusions: The bipolar repetitive and continuous fractionated CFAEs represented different activation patterns. The former was associated with an S wave predominant unipolar morphology which may represent an important focus for maintaining AF. (J Cardiovasc Electrophysiol, Vol. 21, pp. 640‐648, June 2010) 相似文献
30.
TOMOHISA NAGASAO MD PHD JUNPEI MIYAMOTO MD KAICHIRO YOSHIKAWA MD YUICHIRO ANDO MD MAKI NAGASAO MD TATSUO NAKAJIMA MD PHD 《Dermatologic surgery》2007,33(3):344-349
BACKGROUND: Because the "lateral limbs" resulting from conventional Z-plasty form a steep angle against the relaxation skin tension line (RSTL), they often develop hypertrophic change, whereas the "central limbs" become inconspicuous after being realigned parallel to the RSTL. OBJECTIVE: To alleviate the above-mentioned hypertrophic change of the lateral limbs, we modified the conventional Z-plasty and invented a new technique. Because the shape of the flap resembles a bird's beak, we call the technique "beak-plasty." The purpose of this study is to present the new technique. METHODS: The technique is described and effectiveness of the technique is reviewed on 21 patients. In particular, three representative cases are presented with photographs. RESULTS: In all patients, the lateral limbs of the flaps did not become hypertrophic after a minimum follow-up period of 9 months. CONCLUSIONS: Our technique can effectively reduce Z-plasty's risk of postoperative hypertrophy in the lateral limb. Therefore, it can make the scar less conspicuous than in conventional Z-plasty. For this advantage, we recommend our technique as an effective armament for scar revision. The authors have indicated no significant interest with commercial supporters. 相似文献