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排序方式: 共有1795条查询结果,搜索用时 10 毫秒
61.
Kadota Tamami Ogaya Yuko Hatakeyama Rina Nomura Ryota Nakano Kazuhiko 《Odontology / the Society of the Nippon Dental University》2019,107(2):261-267
Odontology - The oral cavity is recognized as a major route for infection by Helicobacter pylori, which colonizes the gastric mucosa. Therapeutic options for elimination in patients with digestive... 相似文献
62.
Atsushi Hamabe Masamitsu Konno Nobuhiro Tanuma Hiroshi Shima Kenta Tsunekuni Koichi Kawamoto Naohiro Nishida Jun Koseki Koshi Mimori Noriko Gotoh Hirofumi Yamamoto Yuichiro Doki Masaki Mori Hideshi Ishii 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(43):15526-15531
63.
Ryota Inokuchi Hideaki Kurata Kiyoshi Endo Yoichi Kitsuta Susumu Nakajima Atsushi Hatamochi Naoki Yahagi 《Medicine》2014,93(28)
As a type of Ehlers-Danlos syndrome (EDS), vascular EDs (vEDS) is typified by a number of characteristic facial features (eg, large eyes, small chin, sunken cheeks, thin nose and lips, lobeless ears). However, vEDs does not typically display hypermobility of the large joints and skin hyperextensibility, which are features typical of the more common forms of EDS. Thus, colonic perforation or aneurysm rupture may be the first presentation of the disease. Because both complications are associated with a reduced life expectancy for individuals with this condition, an awareness of the clinical features of vEDS is important.Here, we describe the treatment of vEDS lacking the characteristic facial attributes in a 24-year-old healthy man who presented to the emergency room with abdominal pain. Enhanced computed tomography revealed diverticula and perforation in the sigmoid colon. The lesion of the sigmoid colon perforation was removed, and Hartmann procedure was performed. During the surgery, the control of bleeding was required because of vascular fragility. Subsequent molecular and genetic analysis was performed based on the suspected diagnosis of vEDS. These analyses revealed reduced type III collagen synthesis in cultured skin fibroblasts and identified a previously undocumented mutation in the gene for a1 type III collagen, confirming the diagnosis of vEDS. After eliciting a detailed medical profile, we learned his mother had a history of extensive bruising since childhood and idiopathic hematothorax. Both were prescribed oral celiprolol. One year after admission, the patient was free of recurrent perforation.This case illustrates an awareness of the clinical characteristics of vEDS and the family history is important because of the high mortality from this condition even in young people. Importantly, genetic assays could help in determining the surgical procedure and offer benefits to relatives since this condition is inherited in an autosomal dominant manner. 相似文献
64.
Tomonori Aoki Atsuo Yamada Kazuharu Aoyama Hiroaki Saito Gota Fujisawa Nariaki Odawara Ryo Kondo Akiyoshi Tsuboi Rei Ishibashi Ayako Nakada Ryota Niikura Mitsuhiro Fujishiro Shiro Oka Soichiro Ishihara Tomoki Matsuda Masato Nakahori Shinji Tanaka Kazuhiko Koike Tomohiro Tada 《Digestive endoscopy》2020,32(4):585-591
65.
Maki Ohara Yumi Funyu Shunsuke Ebara Yuki Sakamoto Ryota Seki Kenta Iijima Akiko Ohishi Junya Kobayashi Kenshi Komatsu Akira Tachibana Hiroshi Tauchi 《Journal of radiation research》2014,55(4):690-698
Ionizing radiation induces DNA double-strand breaks (DSBs). Mammalian cells repair DSBs through multiple pathways, and the repair pathway that is utilized may affect cellular radiation sensitivity. In this study, we examined effects on cellular radiosensitivity resulting from functional alterations in homologous recombination (HR). HR was inhibited by overexpression of the forkhead-associated (FHA) domain-mutated NBS1 (G27D/R28D: FHA-2D) protein in HeLa cells or in hamster cells carrying a human X-chromosome. Cells expressing FHA-2D presented partially (but significantly) HR-deficient phenotypes, which were assayed by the reduction of gene conversion frequencies measured with a reporter assay, a decrease in radiation-induced Mre11 foci formation, and hypersensitivity to camptothecin treatments. Interestingly, ectopic expression of FHA-2D did not increase the frequency of radiation-induced somatic mutations at the HPRT locus, suggesting that a partial reduction of HR efficiency has only a slight effect on genomic stability. The expression of FHA-2D rendered the exponentially growing cell population slightly (but significantly) more sensitive to ionizing radiation. This radiosensitization effect due to the expression of FHA-2D was enhanced when the cells were irradiated with split doses delivered at 24-h intervals. Furthermore, enhancement of radiation sensitivity by split dose irradiation was not seen in contact-inhibited G0/G1 populations, even though the cells expressed FHA-2D. These results suggest that the FHA domain of NBS1 might be an effective molecular target that can be used to induce radiosensitization using low molecular weight chemicals, and that partial inhibition of HR might improve the effectiveness of cancer radiotherapy. 相似文献
66.
67.
Yuichi Goto Shintaro Kawano Ryota Matsubara Takahiro Kiyosue Mitsuhiro Hirano Teppei Jinno Yasuyuki Maruse Takeshi Toyoshima Ryoji Kitamura Hideaki Tanaka Kazunari Oobu Seiji Nakamura 《Clinical & experimental metastasis》2014,31(3):293-306
Epithelial-to-mesenchymal transition (EMT), an essential developmental program, is involved in tumor progression. ΔNp63, a homolog of p53, is associated with the EMT program, but the detailed mechanism remains to be elucidated. In this study, we investigated the role of ΔNp63 in EMT during progression of oral squamous cell carcinoma (OSCC). Five OSCC cell lines and specimens from 78 patients with OSCC were used. The expressions of ΔNp63, p63α, p63β and epithelial markers (cytokeratins 5 and 14) was detected in the OSCC cells, but not in SQUU-B cells (high metastatic potential). E-cadherin was expressed in all OSCC cells. Mesenchymal markers were strongly expressed in the SQUU-B cells. Knockdown of endogenous ΔNp63 in HSC-2 cells induced morphological changes to the spindle shape, decreased the expression of epithelial markers, increased the expression of mesenchymal markers, increased migration and reduced proliferation. By contrast, SQUU-B cells overexpressing ΔNp63β showed changed their morphology from stromal cell-like to epithelial cells. However, E-cadherin expression was not affected by ΔNp63 knockdown or overexpression. Immunohistochemical staining revealed that cancer cells expressing vimentin were found at the invasive front in the OSCC specimens. The intensity of ΔNp63 expression was also decreased in these cells. Interestingly, the vimentin positivity or decreased intensity of ΔNp63 was positively associated with metastases and poor prognosis in the OSCC patients. These results indicated that ΔNp63 downregulation in cancer cells induces a mesenchymal phenotype that is related to tumor progression of OSCC. 相似文献
68.
69.
Satoi Sohei Yamamoto Tomohisa Yamaki So Hirooka Satoshi Hashimoto Daisuke Sakaguchi Tatsuma Ryota Hironori Yui Rintaro Sakuramoto Kazuto Matsushima Hideyuki Yanagimoto Hiroaki Toyokawa Hideyoshi Michiura Taku Inoue Kentaro Sekimoto Mitsugu 《胰腺病学杂志(英文)》2021,(2):99-105
Objective::No ideal training system exists for pancreaticoduodenectomy (PD). We developed an educational system that uses an objective structured assessment of ... 相似文献
70.
Ryota Horibe Taku Hatakeyama Tatsuru Ishikawa Takeyuki Sawai Midori Hashimoto Hiromitsu Domen Yasunari Takakuwa Masaaki Satoh Kaoru Nishiyama 《Internal medicine (Tokyo, Japan)》2022,61(3):401
A 78-year-old woman with multiple lung nodules, epithelial growth factor receptor (EGFR) exon 20 insertion mutations, and diagnosed with advanced lung adenocarcinoma (cT4N3M1a, stage IVA), was referred to our hospital. She received immune checkpoint inhibitor (ICI) therapy. The therapy showed remarkable antitumor effects; only a single nodule remained in the right upper lobe. The nodule was diagnosed as adenocarcinoma through a biopsy. We subsequently performed right upper lobectomy for multiple primary lung cancer (MPLC). The surgical specimen contained EGFR exon 19 deletion mutations and not exon 20 insertion mutations. 相似文献