全文获取类型
收费全文 | 2623篇 |
免费 | 182篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 60篇 |
妇产科学 | 34篇 |
基础医学 | 325篇 |
口腔科学 | 61篇 |
临床医学 | 214篇 |
内科学 | 827篇 |
皮肤病学 | 45篇 |
神经病学 | 192篇 |
特种医学 | 120篇 |
外科学 | 332篇 |
综合类 | 11篇 |
预防医学 | 73篇 |
眼科学 | 17篇 |
药学 | 159篇 |
中国医学 | 1篇 |
肿瘤学 | 331篇 |
出版年
2024年 | 5篇 |
2023年 | 48篇 |
2022年 | 90篇 |
2021年 | 155篇 |
2020年 | 68篇 |
2019年 | 104篇 |
2018年 | 111篇 |
2017年 | 95篇 |
2016年 | 82篇 |
2015年 | 95篇 |
2014年 | 102篇 |
2013年 | 122篇 |
2012年 | 168篇 |
2011年 | 161篇 |
2010年 | 111篇 |
2009年 | 84篇 |
2008年 | 120篇 |
2007年 | 110篇 |
2006年 | 103篇 |
2005年 | 91篇 |
2004年 | 81篇 |
2003年 | 96篇 |
2002年 | 75篇 |
2001年 | 47篇 |
2000年 | 41篇 |
1999年 | 50篇 |
1998年 | 21篇 |
1997年 | 17篇 |
1996年 | 9篇 |
1995年 | 5篇 |
1994年 | 6篇 |
1993年 | 11篇 |
1992年 | 37篇 |
1991年 | 39篇 |
1990年 | 44篇 |
1989年 | 41篇 |
1988年 | 32篇 |
1987年 | 25篇 |
1986年 | 22篇 |
1985年 | 29篇 |
1984年 | 15篇 |
1983年 | 11篇 |
1982年 | 5篇 |
1981年 | 5篇 |
1980年 | 4篇 |
1979年 | 5篇 |
1977年 | 3篇 |
1976年 | 8篇 |
1973年 | 3篇 |
1965年 | 3篇 |
排序方式: 共有2823条查询结果,搜索用时 15 毫秒
61.
62.
63.
Bosutinib-induced osteonecrosis of the jaw in a patient with chronic myeloid leukemia: a case report
Myoken Yoshinari Fujita Yoshinori Imanaka Ryota Toratani Shigeaki 《Oral and maxillofacial surgery》2021,25(3):421-425
Oral and Maxillofacial Surgery - Medication-related osteonecrosis of the jaw (MRONJ) is an uncommon adverse drug reaction that can be induced by certain therapeutic drugs, including antiresorptive... 相似文献
64.
65.
Satoshi Kutsuna Yusuke Asai Kei Yamamoto Michinori Shirano Keiji Konishi Tomohiro Asaoka Masaya Yamato Yukiko Katsuragi Yudai Yamamoto Toshinori Sahara Aya Tamiya Fukumi Nakamura-Uchiyama Naoya Sakamoto Atsushi Kosaka Takuya Washino Ryota Hase Haruki Mito Takashi Kurita Norio Ohmagari 《Journal of infection and chemotherapy》2021,27(4):632-638
IntroductionThe epidemiology of infectious diseases in Japan remains undefined despite the increasing tourism. GeoSentinel, an epidemiological surveillance system for reporting imported infectious diseases, has only two participating facilities in Japan. Although the number of infectious diseases is reported by the National Institute of Infectious Diseases, there is no detailed clinical information about these cases. Therefore, we established J-RIDA (Japan Registry for Infectious Diseases from Abroad) to clarify the status of imported infectious diseases in Japan and provide detailed information.MethodsJ-RIDA was started as a registry of imported infectious diseases. Case registration began in October 2017. Between October 2017 and September 2019, 15 medical institutions participated in this clinical study. The registry collected information about the patient's age, sex, nationality, chief complaint, consultation date, date of onset, whether visit was made to a travel clinic before travel, blood test results (if samples were collected), travel history, and final diagnosis.ResultsOf the 3046 cases included in this study, 46.7% to Southeast Asia, 13.0% to Africa, 13.7% to East Asia, 11.5% to South Asia, 7.5% to Europe, 3.8% to Central and South America, 4.6% to North America, 3.9% to Oceania, and 2.8% to Central and west Asia. More than 85% of chief complaints were fever and general symptoms, gastrointestinal symptoms, respiratory symptoms, or dermatologic problems. The most common diseases were travelers’ diarrhea, animal bite, upper respiratory infection, influenza, and dengue fever.ConclusionsWe summarized two-year cases registered in Japan's imported infectious disease registry. These results will significantly contribute to the epidemiology in Japan. 相似文献
66.
67.
68.
69.
Clinical outcomes of a novel therapeutic vaccine with Tax peptide‐pulsed dendritic cells for adult T cell leukaemia/lymphoma in a pilot study
下载免费PDF全文
![点击此处可从《British journal of haematology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Youko Suehiro Atsuhiko Hasegawa Tadafumi Iino Amane Sasada Nobukazu Watanabe Masao Matsuoka Ayako Takamori Ryuji Tanosaki Atae Utsunomiya Ilseung Choi Tetsuya Fukuda Osamu Miura Shigeo Takaishi Takanori Teshima Koichi Akashi Mari Kannagi Naokuni Uike Jun Okamura 《British journal of haematology》2015,169(3):356-367
Adult T cell leukaemia/lymphoma (ATL) is a human T cell leukaemia virus type‐I (HTLV‐I)‐infected T cell malignancy with poor prognosis. We herein developed a novel therapeutic vaccine designed to augment an HTLV‐I Tax‐specific cytotoxic T lymphocyte (CTL) response that has been implicated in anti‐ATL effects, and conducted a pilot study to investigate its safety and efficacy. Three previously treated ATL patients, classified as intermediate‐ to high‐risk, were subcutaneously administered with the vaccine, consisting of autologous dendritic cells (DCs) pulsed with Tax peptides corresponding to the CTL epitopes. In all patients, the performance status improved after vaccination without severe adverse events, and Tax‐specific CTL responses were observed with peaks at 16–20 weeks. Two patients achieved partial remission in the first 8 weeks, one of whom later achieved complete remission, maintaining their remission status without any additional chemotherapy 24 and 19 months after vaccination, respectively. The third patient, whose tumour cells lacked the ability to express Tax at biopsy, obtained stable disease in the first 8 weeks and later developed slowly progressive disease although additional therapy was not required for 14 months. The clinical outcomes of this pilot study indicate that the Tax peptide‐pulsed DC vaccine is a safe and promising immunotherapy for ATL. 相似文献
70.
Yoshihiro Sudo Yoichi Ezura Ryota Ishida Mitsuko Kajita Hideyo Yoshida Takao Suzuki Takayuki Hosoi Satoshi Inoue Masataka Shiraki Hajime Orimo Hiromoto Ito Mitsuru Emi 《Geriatrics & Gerontology International》2004,4(4):245-249
Background: Osteoporosis is believed to result from the interaction among multiple environmental and genetic determinants that regulate bone-mineral density (BMD).
Methods: To investigate a potentially predisposing genetic factor in the onset of osteoporosis, we looked for a possible association between BMD in adult Japanese women and known polymorphisms in the leukemia inhibitory factor receptor gene (LIFR).
Results: An association analysis of chromosomes from 384 volunteer subjects revealed significant correlation between the −603T > C variant of LIFR and radial BMD ( r = 0.11, P = 0.032) in this test population. Comparisons of mean values of adjusted radial BMD among separate genotypic groups implied an allelic dosage effect, because homozygous carriers of T alleles of that SNP had the highest adjusted BMDs (0.403 ± 0.054 g/cm2 ); women homozygous for the C-allele had the lowest (0.373 ± 0.042 g/cm2 ), and heterozygous individuals had intermediate scores (0.394 ± 0.056 g/cm2 ).
Conclusion: This polymorphism in LIFR may be an important determinant of predisposition to postmenopausal osteoporosis. 相似文献
Methods: To investigate a potentially predisposing genetic factor in the onset of osteoporosis, we looked for a possible association between BMD in adult Japanese women and known polymorphisms in the leukemia inhibitory factor receptor gene (LIFR).
Results: An association analysis of chromosomes from 384 volunteer subjects revealed significant correlation between the −603T > C variant of LIFR and radial BMD ( r = 0.11, P = 0.032) in this test population. Comparisons of mean values of adjusted radial BMD among separate genotypic groups implied an allelic dosage effect, because homozygous carriers of T alleles of that SNP had the highest adjusted BMDs (0.403 ± 0.054 g/cm
Conclusion: This polymorphism in LIFR may be an important determinant of predisposition to postmenopausal osteoporosis. 相似文献