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排序方式: 共有354条查询结果,搜索用时 15 毫秒
351.
Continent urinary reservoirs 总被引:1,自引:0,他引:1
352.
Barry J. Ruijter Jeannette Hofmeijer Marleen C. Tjepkema-Cloostermans Michel J.A.M. van Putten 《Clinical neurophysiology》2018,129(8):1534-1543
Objective
To assess the value of background continuity and amplitude fluctuations of the EEG for the prediction of outcome of comatose patients after cardiac arrest.Methods
In a prospective cohort study, we analyzed EEGs recorded in the first 72?h after cardiac arrest. We defined the background continuity index (BCI) as the fraction of EEG not spent in suppressions (amplitudes <?10?µV for ≥?0.5?s), and the burst-suppression amplitude ratio (BSAR) as the mean amplitude ratio between non-suppressed and suppressed segments. Outcome was assessed at 6?months and categorized as “good” (Cerebral Performance Category 1–2) or “poor” (CPC 3–5).Results
Of the 559 patients included, 46% had a good outcome. Combinations of BCI and BSAR resulted in the highest prognostic accuracies. Good outcome could be predicted at 24?h with 57% sensitivity (95% confidence interval (CI): 48–67) at 90% specificity (95%-CI: 86–95). Poor outcome could be predicted at 12?h with 50% sensitivity (95%-CI: 42–56) at 100% specificity (95%-CI: 99–100).Conclusions
EEG background continuity and the amplitude ratio between bursts and suppressions reliably predict the outcome of postanoxic coma.Significance
The presented features provide an objective, rapid, and reliable tool to assist in EEG interpretation in the Intensive Care Unit. 相似文献353.
Cadherin switching in human prostate cancer progression 总被引:34,自引:0,他引:34
Tomita K van Bokhoven A van Leenders GJ Ruijter ET Jansen CF Bussemakers MJ Schalken JA 《Cancer research》2000,60(13):3650-3654
The progression of carcinomas is associated with the loss of epithelial morphology and a concomitant acquisition of a more mesenchymal phenotype, which in turn is thought to contribute to the invasive and/or metastatic behavior of the malignant process. Changes in the expression of cadherins, "cadherin switching," plays a critical role during embryogenesis, particularly in morphogenetic processes. Loss of E-cadherin is reported to be associated with a poor prognosis; however, thus far, evidence (R. Umbas, et al., Cancer Res. 54: 3929-3933, 1994) for up-regulation of other cadherins has only been reported in vitro, ie., we have found evidence (M. J. G. Bussemakers et al., Int. J. Cancer, 85: 446-450, 2000) for cadherin switching in prostate cancer cell lines (up-regulation of N-cadherin and cadherin-11, two mesenchymal cadherins, in cell lines that lack a functional E-cadherin-catenin adhesion complex). Here, we report on the immunohistochemical analysis of the expression of N-cadherin and cadherin-11 in human prostate cancer specimens. N-cadherin was not expressed in normal prostate tissue; however, in prostatic cancer, N-cadherin was found to be expressed in the poorly differentiated areas, which showed mainly aberrant or negative E-cadherin staining. Cadherin-11 is expressed in the stroma of all prostatic tumors, in the area where stromal and epithelial cells are found. In addition, cadherin-11 is also expressed in a dotted pattern or at the membrane of the epithelial cells of high-grade cancers. In a number of metastatic lesions, N-cadherin and cadherin-11 are expressed homogeneously. These data raise the possibility that cadherin switching plays an important role in prostate cancer metastasis. 相似文献
354.