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排序方式: 共有1646条查询结果,搜索用时 31 毫秒
61.
Anastasios Roumeliotis MD Bimmer E. Claessen MD PhD Samantha Sartori PhD Davide Cao MD Hanbo Qiu Anton Camaj MD MS Johny Nicolas MD Rishi Chandiramani MD Ridhima Goel MD Mauro Chiarito MD Rebecca Torguson MPH Joseph Sweeny MD Nitin Barman MD Prakash Krishnan MD Annapoorna Kini MD Samin K Sharma MD George Dangas MD PhD Roxana Mehran MD 《Catheterization and cardiovascular interventions》2021,98(4):E494-E500
62.
Alexandre Abizaid MD PhD Carlos M. Campos MD PhD Patrícia O. Guimarães MD PhD José de Ribamar Costa Jr. PhD MD Breno A. A. Falcão MD PhD Fernanda Mangione MD Adriano Caixeta MD PhD Pedro A. Lemos MD PhD Fabio S. de Brito Jr. MD PhD Ricardo Cavalcante MD Cristiano Guedes Bezerra MD PhD Leandro Cortes MD Henrique B. Ribeiro MD PhD Francis R. de Souza PhD Natassja Huemer BS Renata M. do Val BS Bruno Caramelli MD PhD Daniela Calderaro MD PhD Felipe G. Lima MD Ludhmila A. Hajjar MD PhD Roxana Mehran MD Roberto Kalil Filho MD PhD the COVID MI investigators 《Catheterization and cardiovascular interventions》2021,98(3):E370-E378
63.
64.
Keisuke Yasumura MD Benjamin Benhuri MD Yuliya Vengrenyuk PhD Artiom Petrov MD Nitin Barman MD Joseph Sweeny MD Vishal Kapur MD Javed Suleman MD Usman Baber MD Roxana Mehran MD Gregg W. Stone MD Annapoorna S. Kini MD Samin K. Sharma MD 《Catheterization and cardiovascular interventions》2021,97(3):E280-E287
65.
Alessio Danilo Inchingolo Angelo Michele Inchingolo Ioana Roxana Bordea Edit Xhajanka Donato Mario Romeo Mario Romeo Carlo Maria Felice Zappone Giuseppina Malcangi Antonio Scarano Felice Lorusso Ciro Gargiulo Isacco Grazia Marinelli Maria Contaldo Andrea Ballini Francesco Inchingolo Gianna Dipalma 《Materials》2021,14(5)
Many different osteotomy procedures has been proposed in the literature for dental implant site preparation. The osseodensification is a drilling technique that has been proposed to improve the local bone quality and implant stability in poor density alveolar ridges. This technique determines an expansion of the implant site by increasing the density of the adjacent bone. The aim of the present investigation was to evaluate the effectiveness of the osseodensification technique for implant site preparation through a literature review and meta-analysis. The database electronic research was performed on PubMed (Medline) database for the screening of the scientific papers. A total of 16 articles have been identified suitable for the review and qualitative analysis—11 clinical studies (eight on animals, three on human subjects), four literature reviews, and one case report. The meta-analysis was performed to compare the bone-to-implant contact % (BIC), bone area fraction occupied % (BAFO), and insertion torque of clockwise and counter-clockwise osseodensification procedure in animal studies. The included articles reported a significant increase in the insertion torque of the implants positioned through the osseodensification protocol compared to the conventional drilling technique. Advantages of this new technique are important above all when the patient has a strong missing and/or low quantity of bone tissue. The data collected until the drafting of this paper detect an improvement when the osseodensification has been adopted if compared to the conventional technique. A significant difference in BIC and insertion torque between the clockwise and counter-clockwise osseodensification procedure was reported, with no difference in BAFO measurements between the two approaches. The effectiveness of the present study demonstrated that the osseodensification drilling protocol is a useful technique to obtain increased implant insertion torque and bone to implant contact (BIC) in vivo. Further randomized clinical studies are required to confirm these pieces of evidence in human studies. 相似文献
66.
Increase of intracellular Ca2+ and relocation of E-cadherin during experimental decompaction of mouse embryos 下载免费PDF全文
Roxana Pey Clarisa Vial Gerald Schatten Mathias Hafner 《Proceedings of the National Academy of Sciences of the United States of America》1998,95(22):12977-12982
To determine the role of intracellular Ca2+ in compaction, the first morphogenetic event in embryogenesis, we analyzed preimplantation mouse embryos under several decompacting conditions, including depletion of extracellular Ca2+, blocking of Ca2+ channels, and inhibition of microfilaments, calmodulin, and intracellular Ca2+ release. Those treatments induced decompaction of mouse morulae and simultaneously induced changes in cytosolic free Ca2+ concentration and deregionalization of E-cadherin and fodrin. When morulae were allowed to recompact, the location of both proteins recovered. In contrast, actin did not change its cortical location with compaction nor with decompaction-recompaction. Calmodulin localized in areas opposite to cell–cell contacts in eight-cell stage embryos before and after compaction. Inhibition of calmodulin with trifluoperazine induced its delocalization while morulae decompacted. A nonspecific rise of intracellular free Ca2+ provoked by ionomycin did not affect the compacted shape. Moreover, the same decompacting treatments when applied to uncompacted embryos did not produce any change in intracellular Ca2+. Our results demonstrate that in preimplantation mouse embryos experimentally induced stage-specific changes of cell shape are accompanied by changes of intracellular free Ca2+ and redistribution of the cytoskeleton-related proteins E-cadherin, fodrin, and calmodulin. We conclude that intracellular Ca2+ specifically is involved in compaction and probably regulates the function and localization of cytoskeleton elements. 相似文献
67.
Cosmina Gingaras Colette Smith Roxana Radoi Diana Sima Mike Youle Luminita Ene 《AIDS care》2019,31(10):1290-1296
ABSTRACTTransition from adolescent to adult care can be challenging for youth living with HIV. We conducted a cohort study of youth born between 1985 and 1993 and infected with HIV parenterally, followed by the same medical team from age 15 years or first clinic visit until age 25 years or 30 November 2016. A longitudinal continuum-of-care was constructed, categorizing individuals’ status for each month of follow-up as: engaged in care (EIC); not in care (NIC: no clinic visits within past year); lost-to-follow-up (LTFU: NIC and did not return to clinic); or died. Five hundred and forty-five individuals (52% male) were followed for 4775 person-years. At age 15, 92% were EIC, decreasing to 84% at age 20 and 74% at age 25. Of those EIC, HIV outcomes improved with age: 79% and 52% had a CD4 ≥200 cells/µl and VL <400 cps/ml at age 15; increasing to 86% and 73% at age 20 and 87% and 80% at age 25. We conclude that youth infected during early childhood tended to disengage from care, even when followed by the same medical team for a lengthy period of time. For those that did engage in care, HIV-related outcomes improved from adolescence through adulthood. 相似文献
68.
Jaya Chandrasekhar Usman Baber Samantha Sartori Melissa Aquino Annapoorna S. Kini Sunil Rao William Weintraub Timothy D. Henry Serdar Farhan Birgit Vogel Sabato Sorrentino Zhen Ge Samir Kapadia Joseph B. Muhlestein Sandra Weiss Craig Strauss Catalin Toma Anthony DeFranco Roxana Mehran 《The Canadian journal of cardiology》2018,34(3):319-329
Background
Potent P2Y12 inhibitors might offer enhanced benefit against thrombotic events in complex percutaneous coronary intervention (PCI). We examined prasugrel use and outcomes according to PCI complexity, as well as analyzing treatment effects according to thienopyridine type.Methods
PROMETHEUS was a multicentre observational study that compared clopidogrel vs prasugrel in acute coronary syndrome patients who underwent PCI (n = 19,914). Complex PCI was defined as PCI of the left main, bifurcation lesion, moderate-severely calcified lesion, or total stent length ≥ 30 mm. Major adverse cardiac events (MACE) were a composite of death, myocardial infarction, stroke, or unplanned revascularization. Outcomes were adjusted using multivariable Cox regression for effect of PCI complexity and propensity-stratified analysis for effect of thienopyridine type.Results
The study cohort included 48.9% (n = 9735) complex and 51.1% (n = 10,179) noncomplex patients. Second generation drug-eluting stents were used in 70.1% complex and 66.2% noncomplex PCI patients (P < 0.0001). Complex PCI was associated with greater adjusted risk of 1-year MACE (hazard ratio [HR], 1.29; 95% confidence interval [CI], 1.20-1.39; P < 0.001). Prasugrel was prescribed in 20.7% of complex and 20.1% of noncomplex PCI patients (P = 0.30). Compared with clopidogrel, prasugrel significantly decreased adjusted risk for 1-year MACE in complex PCI (HR, 0.79; 95% CI, 0.68-0.92) but not noncomplex PCI (HR, 0.91; 95% CI, 0.77-1.08), albeit there was no evidence of interaction (P interaction = 0.281).Conclusions
Despite the use of contemporary techniques, acute coronary syndrome patients who undergo complex PCI had significantly higher rates of 1-year MACE. Adjusted magnitude of treatment effects with prasugrel vs clopidogrel were consistent in complex and noncomplex PCI without evidence of interaction. 相似文献69.
Kenichi Tsujita MD PhD Akiko Maehara MD Gary S. Mintz MD Hiroshi Doi MD PhD Takashi Kubo MD PhD Celia Castellanos MD Jian Liu MD Junqing Yang MD Carlos Oviedo MD Theresa Franklin-Bond MS PA Neil Dasgupta MA Sinan Biro BS Lokesh Dani BA George D. Dangas MD PhD Roxana Mehran MD Ajay J. Kirtane MD Alexandra J. Lansky MD Edward M. Kreps MD Michael B. Collins MD Gregg W. Stone MD Jeffrey W. Moses MD Martin B. Leon MD 《The American journal of cardiology》2008,102(12):1608-1613