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31.
There has been a traditional reluctance to remove a subluxed (ectopic) lens because of the high surgical risk. The use of closed intraocular microsurgical techniques, however, now allows greater intraoperative control with few complications. The authors present the results of subluxed lens extraction, by limbal or pars plana lensectomy, in 44 eyes of 24 patients, in which the indication for surgery was lens subluxation causing a reduction in visual acuity or uncorrectable refractive error. Visual acuity was improved in all cases after surgery, with no significant complications. Patients with reduced visual acuity secondary to ectopic lenses have a good visual prognosis after lensectomy using a closed intraocular microsurgical technique. 相似文献
32.
Lectin-like cell adhesion molecule 1 mediates leukocyte rolling in mesenteric venules in vivo 总被引:54,自引:3,他引:51
During the inflammatory response, granulocytes and other leukocytes adhere to and emigrate from small venules. Before firm attachment, leukocytes are observed rolling slowly along the endothelium in venules of most tissues accessible to intravital microscopy. The molecular mechanism underlying this early type of leukocyte-endothelial interaction is unknown. Leukocyte rolling was investigated in venules (diameter, 40 microns) of the exposed rat mesentery. Micro-infusion of a recombinant soluble chimera (LEC-IgG) of the murine homing receptor lectin-like cell adhesion molecule 1 (LEC-CAM 1; gp90MEL) into individual venules reduced the number of rolling leukocytes by 89% +/- 2% (mean +/- SEM, n = 20 venules), while a similar CD4 chimera (CD4-IgG) had no effect (inhibition 14% +/- 7%, n = 25). Rolling was also greatly reduced by a polyclonal serum against LEC-CAM 1 (inhibition 84% +/- 3%, n = 35); preimmune serum was ineffective (11% +/- 13% inhibition, n = 28). These findings indicate that LEC-CAM 1 mediates the adhesive interaction underlying leukocyte rolling and thus may play an important role in inflammation and in pathologic conditions involving leukocytes. 相似文献
33.
Combined open and laparoscopic approach to chronic pain following open inguinal hernia repair 总被引:1,自引:0,他引:1
Introduction: Chronic groin pain is the most common long-term complication after open inguinal hernia repair. Traditional surgical management
of the associated neuralgia consists of injection therapy followed by groin exploration, mesh removal, and nerve transection.
The resultant hernia defect may be difficult to repair from an anterior approach. We evaluate the outcomes of a combined laparoscopic
and open approach for the treatment of chronic groin pain following open inguinal herniorrhaphy. Methods: All patients who underwent groin exploration for chronic neuralgia after a prior open inguinal hernia repair were prospectively
analyzed. Patient demographics, type of prior hernia repair, and prior nonoperative therapies were recorded. The operation
consisted of a standard three trocar laparoscopic transabdominal preperitoneal hernia repair, followed by groin exploration,
mesh removal, and nerve transection. Outcome measures included recurrent groin pain, numbness, hernia recurrence, and complications.
Results: Twelve patients (11 male and 1 female) with a mean age of 41 years (range 29–51) underwent combined laparoscopic and open
treatment for chronic groin pain. Ten patients complained of unilateral neuralgia, one patient had bilateral complaints, and
one patient complained of orchalgia. All patients failed at least two attempted percutaneous nerve blocks. Prior repairs included
Lichtenstein (n=9), McVay (n=1), plug and patch (n=1), and Shouldice (n=1). There were no intraoperative complications or wound infections. With a minimum of 6 weeks follow up, all patients were
significantly improved. One patient complained of intermittent minor discomfort that required no further therapy. Two patients
had persistent numbness in the ilioinguinal nerve distribution but remained satisfied with the procedure. Conclusions: A combined laparoscopic and open approach for postherniorrhaphy groin pain results in good to excellent patient satisfaction
with no perioperative morbidity. It may be the preferred technique for the definitive management of chronic neuralgia after
prior open hernia repair. 相似文献
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