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51.
Editorial comment 总被引:2,自引:0,他引:2
Ronald Dubner Howard L. Fields Gerald F. Gebhart John D. Loeser Harold Merskey Patrick D. Wall 《Pain》1992,50(3):247-248
52.
Ronald R. Watson PhD Mary E. Mohs MS RD Cteamond Eskelson PhD Richard E. Samptiner MD Barbara Hartmann PhD 《Alcoholism, clinical and experimental research》1986,10(4):364-385
The prevalence and incidence of heavy alcohol consumption are major problems which have been increasing in many countries in recent years. It is crucial for physicians to consistently identify early drinking problems as well as the various end disease states in order to minimize suffering and maximize recovery. This paper reviews the evolutionary development of clinical tools for detection of alcohol abuse. The focus is primarily on clinical/biochemical indicators of alcohol abuse, emphasizing but not limited to changes in hematological characteristics, liver enzyme activity, lipids, immune function factors, hormones, neurological factors, and some physically based tests. Use of test combinations and sophisticated statistical analysis of pattern changes in test batteries evidence increased diagnostic efficiency. 相似文献
53.
Zvi Bar-Shavit Ronald L. Horst Jean C. Chappel F. Patrick Ross Richard W. Gray Steven L. Teitelbaum M.D. 《Calcified tissue international》1986,39(5):328-333
Summary 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is a potent inducer of monocytic differentiation of the human promyelocytic leukemia cell line, HL-60. We have noted that
25-hydroxyvitamin D3 (25(OH)D3) in high doses is also capable of promoting monocytic differentiation of this cell line. To test the possibility that the
latter activity is due to conversion of 25OHD3 to 1,25(OH)2D3 by HL-60, we exposed HL-60 cells to 25OHD3 and analyzed the products by HPLC and radioreceptor assay. When chromatographed in the traditional solvent system (isopropanol-hexane),
a new peak appears which migrates with authentic 1,25(OH)2D3. However, in a solvent system containing dichloromethane, 90% of the peak migrates with another metabolite, 19-Nor-10-Keto-25OHD3 (19-Nor-25OHD3). Production of this metabolite is enhanced by living cells and is synthesized by both virgin HL-60 and those which have
undergone differentiation. We next determined if authentic 19-Nor-25OHD3 also promotes differentiation of this cell. As assessed by appearance of the monocyte-specific surface antigen (63D3) and
macrophage-specific esterase activity, we find that this metabolite does, in fact, induce monocytic differentiation of HL-60
with a potency of approximately 1/200 that of 1,25(OH)2D3 and similar to that of 25OHD3. In agreement with the effect upon cell maturation, 19-Nor-25OHD3 displaces3H-1,25(OH)2D3 from its HL-60 receptor with an efficiency comparable to 25OHD3. Hence, HL-60 cells convert 25OHD3 to 19-Nor-25OHD3, and 19-Nor-25OHD3 induces monocytic differentiation of HL-60 with comparable efficiency to its precursor, 25OHD3. 相似文献
54.
Ruth Dailey Grainger Clifford Levin Lois Allen-Byrd Ronald M. Doctor Howard Lee 《Journal of traumatic stress》1997,10(4):665-671
Controlled studies of treatments effective with victims of natural disasters are almost nonexistent. This is a small study conducted under difficult conditions to test the effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) in treating trauma related reactions following Hurricane Andrew. The results were positive in that EMDR produced significant improvement over wail list controls in perceived posttraumatic avoidance behaviors and thoughts as measured by changes in the Impact of Event Scale and significant improvement in subjective aversive reactions to representative experiences of the hurricane. These results suggest and support other studies that EMDR can be an effective therapeutic intervention for trauma reactions. 相似文献
55.
Ronald A. Bloom M.D. Eugene Libson M.D. Emeric Lax M.D. Hyman Pogrund M.D. 《Skeletal radiology》1986,15(6):455-457
The assimilated os sustentaculi is a projection of bone from the medial aspect of the sustentaculum tali which is surmounted by a similar projection from the medial tubercle of the talus. The accessory joint so formed may develop secondary osteoarthritis changes. This congenital anomaly is very rate. The present report is of 2 additional cases. 相似文献
56.
Child care agencies in Ohio were surveyed concerning their programs and child care workers so as to better understand factors that contribute to job stress, attrition, and satisfaction. The survey provided data regarding the population served at the agencies and the characteristics of child care workers, their services, concerns, desires, and rewards. The findings indicate that environmental variables contribute largely to perceived concern and desired changes, whereas success with children provides a prominent source of job satisfaction. 相似文献
57.
Chronic recurrent multifocal osteomyelitis and psoriasis—A report of a new association and review of related disorders 总被引:3,自引:0,他引:3
Ronald M. Laxer MDCM FRCPC Assistant Professor Abraham D. Shore MD FRCPC Assistant Professor David Manson MD Chief Resident Susan King MD FRCPC Fellow Earl D. Silverman MD FRCPC Assistant Professor Dan M. Wilmot MD FRCPC Assistant Professor 《Seminars in arthritis and rheumatism》1988,17(4):260-270
In summary, we have described two patients with CRMO and psoriasis, and have reviewed the musculoskeletal manifestations associated with pustular eruptions of the palms and soles. In view of the frequent occurrence of PPP in patients with CRMO, we suggest that the occurrence of psoriasis in our two patients is more than coincidence, and that noninfectious, inflammatory lesions of bone may be another musculoskeletal manifestation of psoriasis. This rare association, as well as the association of PPP with disorders associated with new bone formation, may shed new insights on the relatively common finding of periosteal elevation associated with psoriatic arthritis and the occasional severe juxta-articular osteolytic destructive bone lesions seen in psoriatic arthritis. 相似文献
58.
59.
60.
Andrew S. Fix Jeffrey W. Horn Lewis L. Truex Ronald A. Smith Ernesto Gomez 《Acta neuropathologica》1994,88(6):511-519
Cytoplasmic vacuoles appear in neurons of the posterior cingulate/retrosplenial cortex (PC/RS) of rats after treatment with N-methyl-d-aspartate (NMDA) receptor antagonists. Prominent dilatation of mitochondria and endoplasmic reticulum has been described within 2 h; however, the ultrastructural features of vacuole formation are unknown. To investigate this, the present study examined the PC/RS cortex of male rats (age 60–70 days) at 15, 30, 45, 60, 90, and 120 min after subcutaneous treatment with 1 mg/kg of the noncompetitive NMDA antagonist MK-801 (dizocilpine maleate, 5-methyl-10, 11-dihydro-5H-dibenzo [a,d] cyclohepten-5,10-imine). Subtle mitochondrial dilatation was identified in a few neurons as early as 15 min postdose (MPD). By 30 MPD, dilatation was more pronounced in mitochondria and also involved the endoplasmic reticulum and perinuclear space. Ribosomal disaggregation and degranulation were also evident by 30 MPD. At all subsequent time points, dilatation of mitochondria and endoplasmic reticulum progressed in severity. Although the relative involvement of mitochondria and endoplasmic reticulum varied, glia were not involved. These ultrastructural data suggest that after treatment with MK-801, mitochondrial dilatation precedes involvement of endoplasmic reticulum in vacuolization of susceptible PC/RS cortical neurons. The early mitochondrial effects identified in this study suggest an initial metabolic insult that rapidly progresses to affect endoplasmic reticulum and ribosomes. This strengthens the relationship between the ability of certain NMDA antagonists to induce energy perturbations and neuronal vacuoles in the same region of the rat cerebral cortex. 相似文献