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81.
Learning and memory is reflected in the responses of reinforcement-related neurons in the primate basal forebrain 总被引:1,自引:0,他引:1
Certain basal forebrain neurons encode the learned reinforcement value of objects: they respond differentially to visual stimuli that signal availability of fruit juice (positively reinforcing) or saline (negatively reinforcing) obtained by lick responses in visual discrimination tasks. In this report we describe the rapid, learning-related changes in the responses of these neurons during the acquisition and reversal of the reinforcement contingency of a visual discrimination reversal task. The same neurons also responded differentially to novel and familiar stimuli in 2 recognition memory tasks, in which monkeys applied the learned rule that lick responses to novel stimuli elicited saline and responses to familiar stimuli elicited juice. These differential responses to novel and familiar stimuli thus reflected the reinforcement value of the stimuli. A single presentation of a novel or a familiar stimulus was sufficient to elicit a differential response which was maintained even when the stimulus had not been seen recently. The maintenance of the differential response indicates that these neurons are influenced by a durable memory for the stimuli, estimated to be 30 trials on average. These differential neurons were recorded in the substantia innominata, the diagonal band of Broca, and a periventricular region of the basal forebrain. The responses of the reinforcement-related neurons in these 3 regions were similar in most respects. These results support the conclusion that basal forebrain neurons respond to sensory stimuli that, through learning of different contingencies, signal the availability of reinforcement. We suggest that the properties of learning and memory reflected in these neuronal responses are due to afferent pathways from ventromedial regions of the prefrontal and temporal cortices and the amygdala, and that the responses of these neurons provide an enabling mechanism that facilitates the operation of diverse cortical regions in which specific sensory, motor, or mnemonic functions take place. 相似文献
82.
83.
窄蒂肋间穿支型薄皮瓣在手背创面修复中的应用 总被引:3,自引:2,他引:1
介绍一种以肋间动脉皮肤穿支为营养血管的、主要用于修复手背皮肤缺损的薄皮瓣。手术方法是以第4~9肋间血管外侧皮穿支为蒂,蒂部长和宽均为3~5cm,瓣部长宽均可达15cm,远端2/3修薄。术后第7~10天断蒂。应用此窄蒂皮瓣修复15例16只手背创面,皮瓣全部成活。随访6个月~2年,手功能恢复良好。由于手术不需分离肋间主干血管,其操作远较以往报道的岛状或游离肋间血管皮瓣简便和安全,为修复手背创面的理想皮瓣 相似文献
84.
Musculoskeletal modelling in determining the effect of botulinum toxin on the hamstrings of patients with crouch gait 总被引:2,自引:0,他引:2
NS Thompson FRCS RJ Baker PhD AP Cosgrove MD FRCS IS Corry MD FRCS HK Graham MD FRCS FRACS 《Developmental medicine and child neurology》1998,40(9):622-625
This study aimed to determine the effect of hamstring botulinum toxin A (Btx-A) injection in 10 children with crouch gait in terms of changes in muscle length and lower-limb kinematics. Before Btx-A injection limb kinematics were recorded. Maximum hamstring lengths and excursions were calculated by computer modelling of the lower limb. Data were compared with the averaged hamstring lengths of 10 control children. Hamstrings were denned as short if their length was shorter than the average maximum length minus one standard deviation. Gait analysis was repeated 2 weeks after isolated hamstring Btx-A injection. Pre- and postinjection kinematic data and muscle lengths were then compared. Four of 18 injected limbs in three subjects had short medial hamstring before injection, none of the subjects had short lateral hamstrings. Muscle excursion was significantly reduced in the short and adequate maximum muscle length groups. A significant increase in the semimembranosus and semitendinosus length in all of the injected limbs was noted. Only in the short muscle group was a significant increase in muscle excursion observed. Knee extension improved by 13° in the adequate muscle length group and by 15.6° in the short muscle length group. Pelvic tilt and hip flexion increased in both groups non-significantly. Average walking speed postinjection increased from 0.60 ms-1 to 0.71 ms-1 . Short hamstrings are over-diagnosed in crouch gait. Hamstring Btx-A injection in patients with crouch gait produces significant, repeatable muscle lengthening and improved ambulatory function. 相似文献
85.
L Agius B J Rolls E A Rowe D H Williamson 《International journal of obesity (2005)》1983,7(5):447-452
Lactating rats made obese before conception by feeding high energy foods show a decreased rate of lipogenesis in vivo in mammary gland, but not in liver. Obese lactating rats have an increased hepatic fat content, together with moderate increase in blood ketone bodies. It is suggested that these changes are due to mobilization during lactation of the expanded adipose tissue lipid pool in the obese rats which results in overloading the liver with fatty acids. The concomitant increase in ketone body concentrations may inhibit glucose utilization and hence lipogenesis in the lactating mammary gland of obese rats. 相似文献
86.
The authors describe a magnetic resonance imaging method for examination of the glenoid labrum of the shoulder joint that utilizes a radial fast-imaging sequence. Seven shoulders were examined: a total of five in three healthy asymptomatic volunteers, one in a symptomatic patient not suspected of having a lesion of the glenoid labrum, and one in a patient with recurrent shoulder dislocation and surgical proof of an extensive tear of the labrum. The preliminary results suggest that this technique may advantageously demonstrate pathologic changes in the glenoid labrum and may contribute to the evaluation of the unstable and painful shoulder. 相似文献
87.
Sijens PE; Wijrdeman HK; Moerland MA; Bakker CJ; Vermeulen JW; Luyten PR 《Radiology》1988,169(3):615-620
To assess the potential of in vivo magnetic resonance (MR) spectroscopy for breast cancer, hydrogen-1 and phosphorus-31 MR spectra of five malignant human breast tumors were compared with those of unaffected breast tissue. The water-to-fat ratio was high in the tumors (average, 2.2) but low in the unaffected tissue (average, 0.3). The P-31 spectrum of normal breast tissue showed low levels of phosphomonoesters (PMEs), inorganic phosphate, phosphodiesters (PDEs), and ATP. In addition, an intense phosphocreatine (PCr) signal was observed in breast tissue of young women: The relative intensities of the PCr and ATP signals had a mean value of 1.9. The tumor spectrum showed elevated levels of PMEs, Pi, and PDEs, while no PCr was seen (PCr/ATP less than 0.2). In two breast cancers treated with radiation therapy, resulting in a decrease of tumor volume of more than 50%, a similar change in the tumor P-31 spectrum was observed: An intense PCr signal developed (PCr/ATP = 1.1). Control experiments indicated that the appearance of PCr after radiation therapy was the result of a radiation-induced metabolic change in the tumor itself. 相似文献
88.
THe effects of the gut microflora and dietary fibre on energy utilization by the chick 总被引:1,自引:0,他引:1
1. Groups of adult colostimized chickens were given diets with and without dietary fibre in the form of bagasse or wheat straw. The fibrous materials were analysed for their contents of cellulose, hemicellulose and lignin. The digestible energies (DE) and metabolizable energies (ME) of these diets were measured by a balance method. 2. Groups of germ-free and conventional chicks aged 4 weeks were given diets with and without penicillin or with and without graded levels of wheat straw as a source of fibre and the ME of these diets were determined. 3. The incorporation of the forms of dietary fibre tested reduced the DE and the ME of the diets in adult conventional chickens and the ME in young germ-free and conventional chicks. Both DE and ME were reduced in proportions that suggested that the dietary fibre present was acting largely as an inactive diluent of the dietary energy and was not affecting the absorption of other nutrients. In the young germ-free and conventional chicks, there was a linear relationship between the proportion of wheat straw in one diet and the reduction ME. 4. Dietary penicillin did not alter the ME of the diet in either the germ-free or the conventional environments. 5. The reduction of ME with incorporation of wheat straw was less in conventional than in germ-free chicks. It is suggested that this may be due to the ability of chicks with a gut flora to obtain a small amount of energy from wheat straw. 相似文献
89.
90.