全文获取类型
收费全文 | 2247篇 |
免费 | 131篇 |
国内免费 | 32篇 |
专业分类
耳鼻咽喉 | 89篇 |
儿科学 | 39篇 |
妇产科学 | 51篇 |
基础医学 | 328篇 |
口腔科学 | 39篇 |
临床医学 | 174篇 |
内科学 | 295篇 |
皮肤病学 | 144篇 |
神经病学 | 242篇 |
特种医学 | 148篇 |
外科学 | 296篇 |
综合类 | 24篇 |
预防医学 | 81篇 |
眼科学 | 71篇 |
药学 | 139篇 |
中国医学 | 12篇 |
肿瘤学 | 238篇 |
出版年
2023年 | 8篇 |
2022年 | 41篇 |
2021年 | 45篇 |
2020年 | 24篇 |
2019年 | 60篇 |
2018年 | 46篇 |
2017年 | 61篇 |
2016年 | 65篇 |
2015年 | 122篇 |
2014年 | 112篇 |
2013年 | 137篇 |
2012年 | 158篇 |
2011年 | 169篇 |
2010年 | 99篇 |
2009年 | 113篇 |
2008年 | 148篇 |
2007年 | 131篇 |
2006年 | 122篇 |
2005年 | 102篇 |
2004年 | 86篇 |
2003年 | 61篇 |
2002年 | 46篇 |
2001年 | 47篇 |
2000年 | 51篇 |
1999年 | 35篇 |
1998年 | 19篇 |
1997年 | 21篇 |
1996年 | 26篇 |
1995年 | 10篇 |
1994年 | 24篇 |
1993年 | 17篇 |
1992年 | 15篇 |
1991年 | 16篇 |
1990年 | 16篇 |
1989年 | 24篇 |
1988年 | 12篇 |
1987年 | 15篇 |
1986年 | 17篇 |
1985年 | 11篇 |
1984年 | 8篇 |
1983年 | 8篇 |
1982年 | 7篇 |
1981年 | 11篇 |
1980年 | 8篇 |
1979年 | 4篇 |
1977年 | 6篇 |
1975年 | 6篇 |
1974年 | 6篇 |
1973年 | 8篇 |
1972年 | 2篇 |
排序方式: 共有2410条查询结果,搜索用时 109 毫秒
71.
Prognostic value of metabolic tumor volume as measured by fluorine‐18‐fluorodeoxyglucose positron emission tomography/computed tomography in nasopharyngeal carcinoma 下载免费PDF全文
72.
73.
74.
75.
YH Kim SY Park J Park YS Kim EM Hwang JY Park GS Roh HJ Kim SS Kang GJ Cho WS Choi 《Diabetologia》2012,55(10):2835-2844
Aims/hypothesis
The study aimed to evaluate the efficacy of recombinant adenovirus expressing αA-crystallin (Ad-αAc-Gfp) in reducing pericyte loss within retinal vasculature in early diabetes. 相似文献76.
Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration 总被引:1,自引:0,他引:1
Y Murakami H Matsumoto M Roh J Suzuki T Hisatomi Y Ikeda JW Miller DG Vavvas 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(36):14598-14603
Retinitis pigmentosa comprises a group of inherited retinal photoreceptor degenerations that lead to progressive loss of vision. Although in most cases rods, but not cones, harbor the deleterious gene mutations, cones do die in this disease, usually after the main phase of rod cell loss. Rod photoreceptor death is characterized by apoptotic features. In contrast, the mechanisms and features of subsequent nonautonomous cone cell death remain largely unknown. In this study, we show that receptor-interacting protein (RIP) kinase mediates necrotic cone cell death in rd10 mice, a mouse model of retinitis pigmentosa caused by a mutation in a rod-specific gene. The expression of RIP3, a key regulator of programmed necrosis, was elevated in rd10 mouse retinas in the phase of cone but not rod degeneration. Although rd10 mice lacking Rip3 developed comparable rod degeneration to control rd10 mice, they displayed a significant preservation of cone cells. Ultrastructural analysis of rd10 mouse retinas revealed that a substantial fraction of dying cones exhibited necrotic morphology, which was rescued by Rip3 deficiency. Additionally, pharmacologic treatment with a RIP kinase inhibitor attenuated histological and functional deficits of cones in rd10 mice. Thus, necrotic mechanisms involving RIP kinase are crucial in cone cell death in inherited retinal degeneration, suggesting the RIP kinase pathway as a potential target to protect cone-mediated central and peripheral vision loss in patients with retinitis pigementosa. 相似文献
77.
Seo SW Lee JH Jang SM Kim ST Chin J Kim GH Kim JH Roh JH Kim MJ Kim SH Na DL 《Archives of gerontology and geriatrics》2012,54(1):192-196
The neurochemical alterations in the entorhinal cortex have not yet been measured, even though the entorhinal cortex is the earliest involved brain region in aMCI. In this study, we investigated whether brain regions including the entorhinal cortex would show early involvement of neurochemical abnormalities in aMCI, and whether magnetic resonance spectroscopy (MRS) abnormalities might be a predictive marker of conversion of aMCI to Alzheimer's disease (AD). MRS was performed on 13 aMCI patients and 11 patients with no cognitive impairment (NCI). Localizing voxels were placed within the entorhinal cortex, hippocampus, posterior cingulate gyrus, and occipital white matter in the dominant hemisphere. N-acetyl aspartate/creatinine (NAA/Cr) ratios in the entorhinal cortex were significantly lower in aMCI patients than in NCI subjects. After a three-year follow-up, seven aMCI patients converted to AD and six remained stable. Baseline NAA/Cr ratios of entorhinal cortex were decreased in converters, compared to NCI. Our study suggested the entorhinal cortex is the earliest site that is subject to neurochemical alteration in aMCI patients, and baseline MRS metabolite ratios in the entorhinal cortex can be a marker for predicting conversion of aMCI to AD. 相似文献
78.
79.
80.
Sang?Yeob?Lee Yong?Min?Jo Won?Tae?Chung Sung?Hyun?Kim Seung?Young?Kim Mee?Sook?Roh Sung?Won?LeeEmail author 《Rheumatology international》2012,32(4):1065-1068
Kaposi sarcoma (KS) is a vascular neoplasm mainly affecting the skin of the limbs that has previously been associated with
rheumatoid arthritis (RA). When compared with the RA patients treated with corticosteroids and immunosuppressive drugs, the
reported number of KS in RA patients was very rare. Although the exact mechanisms of developing KS in RA patients are unclear,
some drugs which include corticosteroid have been suggested as an etiological factor in previous case reports of RA and KS.
We report, here in, another case of KS associated with the initiation of leflunomide in a patient with RA. 相似文献