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排序方式: 共有4936条查询结果,搜索用时 10 毫秒
91.
Magrì D Piccirillo G Bucci E Pignatelli G Cauti FM Morino S Latino P Santini D Marrara F Volpe M Antonini G Testa M 《International journal of cardiology》2012,154(3):259-264
Objectives
To assess ventricular dysfunction and ventricular interaction after repair of Tetralogy of Fallot (ToF) employing echocardiography speckle-tracking and cardiac magnetic resonance imaging (CMR).Background
Severe pulmonary regurgitation and right ventricular (RV) dysfunction are common after repair of ToF and may also affect the shape and function of the left ventricle (LV). Recent studies suggest that LV dysfunction may be of particular prognostic value.Methods and results
Twenty-one consecutive adults with repaired ToF (15 male, mean age 38 ± 11 years, 7 with severe PR) underwent a comprehensive echocardiographic exam including speckle-tracking analysis, CMR and cardiopulmonary exercise testing. Twenty-one subjects without relevant heart disease served as controls. Echocardiographically measured RV diameters correlated with RV volumes obtained from CMR (r = 0.63; p = 0.006). In addition, a close correlation was found between RV and LV function on CMR (r = 0.74, p = 0.002), speckle-tracking LV and RV peak longitudinal 2D strain (r = 0.66, p = 0.003) and mitral and tricuspid annular plain systolic excursion (r = 0.71, p = 0.0003). While LV ejection fraction was normal in the majority of patients and not different from controls, LV longitudinal strain was significantly reduced in ToF patients (− 16.5 ± 3.3 vs. -20.5 ± 2.7%, p = 0.0001).Conclusion
Left and right ventricular function both by CMR and speckle-tracking is interrelated in adults with repaired ToF. Despite normal LV ejection fraction, 2D longitudinal strain is significantly reduced in ToF patients, suggesting subclinical LV myocardial damage. Considering the potential prognostic value of LV dysfunction in ToF, this measurement may gain importance and should be included in future outcome studies. 相似文献92.
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Prevalence, characteristics and the very existence of neurofibromatosis-associated diffuse lung disease remain unclear, mostly
because the few studies that looked at pulmonary involvement in such patients used chest X-ray as diagnostic mean. We report
on the clinical, functional and HRCT findings in a patient with neurofibromatosis-associated diffuse lung disease and provide
a short literature review. 相似文献
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Crudeli CM Aulicino PC Rocco CA Bologna R Mangano A Sen L 《AIDS research and human retroviruses》2012,28(7):685-692
The aim of the study was to investigate the prevalence and persistence of syncytium-inducing (SI) strains in HIV-1-infected children along time of infection and to evaluate the influence of antiretroviral therapy and host factors on viral tropism. This is a retrospective analysis carried out in 267 HIV-1 vertically infected children from an Argentinean cohort. The viral phenotype was screened in MT-2 cells and coreceptor usage confirmed by the GHOST cell assay. Also, CD4(+) T cell count, viral load, antiretroviral therapy, and human CCR5-Δ32 and CCR2-64I genotypes were analyzed. A high frequency of HIV-1 SI/CXCR4-using variants (22%) was found among children within the first trimester of life, reaching 46% after 10 years of infection. At acute infection, zidovudine prophylaxis did not significantly affect the proportions of SI HIV-1 strains, while their presence was favored by the CCR5(+)/Δ32 genotype. Interestingly, the majority of the early SI strains did not persist over time, probably due to a higher susceptibility to antiretroviral (ARV) treatment or immunologic pressure. At the chronic stage, SI variants emerged even in the presence of HAART reaching 36% at 120 months of infection. Also the HIV-1 SI phenotype was associated with lower CD4(+) T cell counts all along the course of infection. These findings highlight the need to evaluate the presence of SI/CXCR4 variants early at primary infection. This will make it possible to optimize the use of CCR5 inhibitors in children who are apparently carriers of the R5 virus preventing early therapeutic failure due to the reemergence of SI strains from reservoirs. 相似文献
100.
Calkins H Kuck KH Cappato R Brugada J Camm AJ Chen SA Crijns HJ Damiano RJ Davies DW DiMarco J Edgerton J Ellenbogen K Ezekowitz MD Haines DE Haissaguerre M Hindricks G Iesaka Y Jackman W Jalife J Jais P Kalman J Keane D Kim YH Kirchhof P Klein G Kottkamp H Kumagai K Lindsay BD Mansour M Marchlinski FE McCarthy PM Mont JL Morady F Nademanee K Nakagawa H Natale A Nattel S Packer DL Pappone C Prystowsky E Raviele A Reddy V Ruskin JN Shemin RJ Tsao HM Wilber D 《Europace : European pacing, arrhythmias, and cardiac electrophysiology》2012,14(4):528-606