Reports of acute combined central and peripheral nervous system acquired inflammatory demyelination are rare in children. This study aimed to (1) define the clinical features and prognoses of patients with this entity; and (2) compare these patients with children presenting isolated acute central or peripheral nervous system demyelination. A retrospective chart review of 523 children with central or peripheral nervous system demyelination hospitalized between 1993-2006 was undertaken. Among these, 93 fulfilled criteria (clinical features and positive magnetic resonance imaging or electromyography/nerve conduction studies) for either acute central (n = 37; 39.8%) or peripheral (n = 43; 46%) nervous system demyelination, or a combination of the two (n = 13; 14%). Significant differences between groups were evident for age (median, 10 versus 7 versus 11 years, respectively; P = 0.047), admission to pediatric intensive care unit (8% versus 30% versus 58%, respectively; P = 0.001), length of hospital stay (median, 8 versus 9 versus 29 days, respectively; P < 0.001), treatment with steroids (52% versus 7% versus 75%, respectively; P < 0.001) and immunoglobulins (11% versus 81% versus 75%, respectively; P < 0.001), and poor evolution (3% versus 12% versus 54%, respectively; P = 0.002). This entity in children is not rare, and has a poorer outcome than isolated central or peripheral nervous system demyelination. Assessment is needed for a better understanding of risk factors, etiologies, management, and prognosis. 相似文献
To develop consensus guidelines for use of recombinant activated factor VII (rFVIIa) in massive hemorrhage.
Methods
A guidelines committee derived the recommendations using clinical trial and case series data identified through searches of available databases. Guidelines were graded on a scale of A-E according to the strength of evidence available. Consensus was sought among the committee for each recommendation.
Results
A recommendation for use of rFVIIa in blunt trauma was made (grade B). rFVIIa might also be beneficial in post-partum hemorrhage (grade E), uncontrolled bleeding in surgical patients (grade E) and bleeding following cardiac surgery (grade D). rFVIIa could not be recommended for use: in penetrating trauma (grade B); prophylactically in elective surgery (grade A) or liver surgery (grade B); or in bleeding episodes in patients with Child-Pugh A cirrhosis (grade B). Efficacy of rFVIIa was considered uncertain in bleeding episodes in patients with Child-Pugh B and C cirrhosis (grade C). Monitoring of rFVIIa efficacy should be performed visually and by assessment of transfusion requirements (grade E), while thromboembolic adverse events are a cause for concern. rFVIIa should not be administered to patients considered unsalvageable by the treating medical team.
Conclusion
There is a rationale for using rFVIIa to treat massive bleeding in certain indications, however, only adjunctively to the surgical control of bleeding once conventional therapies have failed. Lack of data from randomized, controlled clinical trials, and possible publication bias of the case series data, limits the strength of the recommendations that can be made. 相似文献
The present study evaluates the influence of different amounts of fat added to starch on postprandial glucose metabolism (exogenous and endogenous). Nine women (24 (se 2) years old, BMI 20.4 (se 0.7) kg/m(2)) ingested 1 week apart 75 g glucose equivalent of (13)C-labelled starch in the form of pasta without (low fat; LF) or with 15 (medium fat; MF) or 40 (high fat; HF) g sunflower oil. During the 7 h following meal consumption, plasma glucose, non-esterified fatty acids, triacylglycerols (TG) and insulin concentrations, and endogenous (using [6,6-(2)H(2)]glucose) and exogenous glucose turnover were determined. With MF and HF meals, a lower postprandial glucose peak was observed, but with a secondary recovery. A decrease in exogenous glucose appearance explained lower glycaemia in HF. At 4 h after the HF meal the insulin, insulin:glucose and postprandial blood TG were higher than those measured after the LF and MF meals. Despite higher insulinaemia, total glucose disappearance was similar and endogenous glucose production was suppressed less than after the LF and MF meals, suggesting insulin resistance. Thus, the addition of a large amount of fat appears to be unfavourable to glucose metabolism because it leads to a feature of insulin resistance. On the contrary, the MF meal did not have these adverse effects, but it was able to decrease the initial glycaemic peak. 相似文献
Background: Halothane induces negative inotropic and lusitropic effects in myocardium. It has been suggested that halothane potentiates beta-adrenoceptor stimulation. However, its effects on the inotropic response to alpha-adrenoceptor stimulation and its effects on the lusitropic effects of alpha- and beta-adrenoceptor stimulation are unknown.
Methods: The effects of halothane (0.5 and 1 minimum alveolar concentration [MAC]) on the inotropic responses induced by phenylephrine (10 sup -8 to 10 sup -4 M) and isoproterenol (10 sup -8 to 10 sup -4 M) were studied in rat left ventricular papillary muscles in vitro (in Krebs-Henseleit solution at 29 degrees Celsius, pH 7.40, with 0.5 mM calcium and stimulation frequency at 12 pulses/min). The lusitropic effects were studied in isotonic (R1) and isometric (R2) conditions.
Results: One MAC halothane induced a negative inotropic effect (54 +/- 3%, P < 0.05), increased R1 (109 +/- 3%, P < 0.05), and decreased R2 (88 +/- 2%, P < 0.05). In control groups, phenylephrine (137 +/- 7%, P > 0.05) and isoproterenol (162 +/- 6%, P < 0.05) induced a positive inotropic effect. Halothane did not significantly modify the positive inotropic effect of calcium, suggesting that it did not modify the inotropic reserve of papillary muscles. In contrast, 1 MAC halothane enhanced the positive inotropic effects of phenylephrine (237 +/- 19%, P < 0.05) and isoproterenol (205 +/- 11%, P < 0.05). Halothane did not modify the lusitropic effect of phenylephrine under high or low load. In contrast, 1 MAC halothane impaired the positive lusitropic effect of isoproterenol under low load (P < 0.05), whereas it did not modify the positive lusitropic effect of isoproterenol under high load. 相似文献
Cortical somatosensory evoked potentials (CSEP) allow monitoring of spinal
cord function during surgery. Ketamine has been shown to enhance CSEP
amplitude, but there is no previous study comparing its effects with those
of other anaesthetic regimens. Therefore, we have compared the effects of
ketamine with those of fentanyl, both combined with midazolam, on CSEP
monitoring during major spine surgery. Twenty patients with normal
preoperative CSEP were allocated randomly to a ketamine or fentanyl group.
Anaesthesia was induced with ketamine 3 mg kg-1 or fentanyl 6 micrograms
kg-1 i.v., and midazolam 0.3 mg kg-1 i.v in both groups, and maintained
with continuous i.v infusion of ketamine 2 mg kg-1 h-1 or fentanyl 3
micrograms kg-1 h-1, combined in both groups with midazolam 0.15 mg kg-1
h-1 and 60% nitrous oxide in oxygen. CSEP were elicited by tibial posterior
nerve stimulation and measured P1 and N1 latencies, and P1-N1 amplitude,
CSEP were recorded before and after induction, at 15 min, 1 and 2 h after
induction, during skin closure and after removal of nitrous oxide. Both
groups were comparable in characteristics, duration of surgery, mean
arterial pressure and temperature. CSEP latencies were not significantly
affected in either group. CSEP amplitude decreased significantly over time
in the fentanyl group (from mean 2.02 (SEM 0.41) to 0.95 (0.17) microV, P
< 0.05), but not in the ketamine group (from 1.33 (0.36) to 1.05 (0.31)
microV, ns). Nevertheless, we did not observe any significant differences
in amplitudes or latencies between the two groups. The delay in obtaining
the first voluntary postoperative motor response was significantly greater
in the ketamine group (170 (54) vs 55 (17) min, P < 0.01). Both ketamine
and fentanyl allowed us to obtain reliable CSEP during major spine surgery,
and there were no significant difference between these two anaesthetic
regimens for CSEP monitoring, but a longer delay for voluntary
postoperative motor assessment was observed in the ketamine group.
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