全文获取类型
收费全文 | 1232篇 |
免费 | 136篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 56篇 |
妇产科学 | 11篇 |
基础医学 | 168篇 |
口腔科学 | 8篇 |
临床医学 | 187篇 |
内科学 | 304篇 |
皮肤病学 | 4篇 |
神经病学 | 43篇 |
特种医学 | 209篇 |
外科学 | 97篇 |
综合类 | 33篇 |
一般理论 | 1篇 |
预防医学 | 96篇 |
眼科学 | 36篇 |
药学 | 91篇 |
肿瘤学 | 47篇 |
出版年
2023年 | 8篇 |
2021年 | 11篇 |
2019年 | 11篇 |
2018年 | 14篇 |
2017年 | 12篇 |
2016年 | 13篇 |
2015年 | 25篇 |
2014年 | 26篇 |
2013年 | 43篇 |
2012年 | 53篇 |
2011年 | 59篇 |
2010年 | 33篇 |
2009年 | 37篇 |
2008年 | 40篇 |
2007年 | 66篇 |
2006年 | 37篇 |
2005年 | 42篇 |
2004年 | 40篇 |
2003年 | 30篇 |
2002年 | 37篇 |
2001年 | 28篇 |
2000年 | 41篇 |
1999年 | 26篇 |
1998年 | 39篇 |
1997年 | 32篇 |
1996年 | 43篇 |
1995年 | 26篇 |
1994年 | 25篇 |
1993年 | 33篇 |
1992年 | 16篇 |
1991年 | 14篇 |
1990年 | 25篇 |
1989年 | 37篇 |
1988年 | 45篇 |
1987年 | 35篇 |
1986年 | 24篇 |
1985年 | 29篇 |
1984年 | 12篇 |
1983年 | 17篇 |
1982年 | 22篇 |
1981年 | 13篇 |
1980年 | 16篇 |
1979年 | 12篇 |
1977年 | 11篇 |
1976年 | 21篇 |
1975年 | 11篇 |
1973年 | 8篇 |
1970年 | 10篇 |
1968年 | 6篇 |
1966年 | 7篇 |
排序方式: 共有1392条查询结果,搜索用时 15 毫秒
51.
Abnormal goblet cell glycoconjugates in rectal biopsies associated with an increased risk of neoplasia in patients with ulcerative colitis: early results of a prospective study 总被引:8,自引:0,他引:8
下载免费PDF全文
![点击此处可从《Gut》网站下载免费的PDF全文](/ch/ext_images/free.gif)
A group of 18 patients with stable ulcerative colitis involving the entire colon for at least eight years was subjected to a biopsy of normal appearing rectal mucosa and followed prospectively over four years for the development of either dysplasia or cancer. Goblet cell glycoconjugate structure was examined in the rectal biopsies using fluorescein conjugated lectins. At the beginning of the study, 13 of the 18 patients had abnormalities of goblet cell mucin or cytoplasmic glycoconjugates in the rectal biopsies. Dysplasia subsequently developed in six and carcinoma in one of these patients. Among the five patients with normal lectin binding studies in the initial rectal biopsies, colonic dysplasia has subsequently developed in one. The abnormalities seen in the rectal goblet cells resembled in part those previously seen in immature and neoplastic colonic cells. The dysplastic tissues all contained the form of mucin which has been found in other neoplastic colonic tissues. This preliminary report after four years of prospective study suggests that abnormalities of glycoconjugate structure may be associated with, and may precede, neoplastic events in the setting of chronic ulcerative colitis. 相似文献
52.
Rosinski KV Fujii N Mito JK Koo KK Xuereb SM Sala-Torra O Gibbs JS Radich JP Akatsuka Y Van den Eynde BJ Riddell SR Warren EH 《Blood》2008,111(9):4817-4826
The Y chromosome encodes male-specific minor histocompatibility (H-Y) antigens that stimulate T- and B-lymphocyte responses after sex-mismatched allogeneic hematopoietic cell transplantation (HCT). A CD8(+) cytotoxic T lymphocyte (CTL) clone that recognizes a novel HLA-B*2705-restricted H-Y antigen encoded by the DDX3Y gene was isolated from a male who had received a hematopoietic cell graft from his human leukocyte antigen (HLA)-identical sister. The antigenic peptide is a decamer that differs from the homologous DDX3X-encoded peptide at 4 positions. Expression of DDX3Y and of the H-Y epitope that it encodes was examined by quantitative polymerase chain reaction (PCR) and by CTL recognition assays. Expression of DDX3Y is detected in all myeloid and lymphoid leukemic cells that carry an intact Y chromosome. Moreover, the DDX3Y-encoded H-Y epitope is presented on the surface of both myeloid and lymphoid leukemic cells from male HLA-B*2705(+) patients. DDX3Y-specific CTLs prevent engraftment of human acute leukemia in nonobese diabetic/severe combined immune deficient mice, demonstrating that the DDX3Y-encoded H-Y antigen is also expressed in leukemic stem cells. These results demonstrate that CD8(+) T-cell responses against DDX3Y have the potential to contribute to graft-versus-leukemia (GVL) activity after female into male allogeneic HCT. This study is registered at http://clinicaltrials.gov as NCT00107354. 相似文献
53.
54.
55.
Repeatability and sensitivity of
measurements in patients with head and neck squamous cell carcinoma at 3T
下载免费PDF全文
![点击此处可从《Journal of magnetic resonance imaging : JMRI》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Rafal Panek PhD Liam Welsh PhD Alex Dunlop PhD Kee H. Wong MSc Angela M. Riddell MD Dow‐Mu Koh MD Maria A. Schmidt PhD Simon Doran PhD Dualta Mcquaid PhD Georgina Hopkinson PgDip Cheryl Richardson DCR Christopher M. Nutting PhD Shreerang A. Bhide PhD Kevin J. Harrington PhD Simon P. Robinson PhD Kate L. Newbold MD Martin O. Leach PhD 《Journal of magnetic resonance imaging : JMRI》2016,44(1):72-80
56.
Skepticism toward infant pain characterized much of 20th century research and clinical practice, with infant surgery routinely conducted with minimal or no anesthesia into the 1980s. This paper offers a historical exploration of how this view became common by reviewing and analyzing the experimental infant pain research of the 19th and early 20th centuries that contributed to the development of infant pain denial. These experiments used pinprick and electric shock, and the results were generally interpreted as evidence of infants’ underdeveloped pain perception, attributed to their lack of brain maturation. Even clear responses to noxious stimuli were often dismissed as reflex responding. Later these experimental findings were used by anesthesiologists to support the lessened use of anesthesia for infants. Based on the reviewed literature, this paper suggests that 4 interrelated causes contributed to the denial of infant pain: the Darwinian view of the child as a lower being, extreme experimental caution, the mechanistic behaviorist perspective, and an increasing emphasis on brain and nervous system development. Ultimately this history can be read as a caution to modern researchers to be aware of their own biases, the risks of null hypothesis testing, and a purely mechanistic view of infants.PerspectiveThis article reviews the history of 19th and early 20th century infant pain research, tracing how the widely accepted belief that infants could not feel pain developed in the period prior to the growing acceptance of infant pain. Four interrelated causes are posited to help explain the tolerance of infant pain denial until recent times. 相似文献
57.
Delivering dignified care: A realist synthesis of evidence that promotes effective listening to and learning from older people's feedback in acute care settings
下载免费PDF全文
![点击此处可从《Journal of clinical nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Megan Dickson BSc RGN Helen Riddell BA MSc RGN Fiona Gilmour BSc RGN Brendan McCormack D. Phil BSc 《Journal of clinical nursing》2017,26(23-24):4028-4038
58.
A remote haploscopic photorefractor was used to assess objective binocular vergence and accommodation responses in 157 full-term healthy infants aged 1-6 months while fixating a brightly coloured target moving between fixation distances at 2, 1, 0.5 and 0.33 m. Vergence and accommodation response gain matured rapidly from 'flat' neonatal responses at an intercept of approximately 2 dioptres (D) for accommodation and 2.5 metre angles(MA) for vergence, reaching adult-like values at 4 months. Vergence gain was marginally higher in females (p = 0.064), but accommodation gain (p = 0.034) was higher and accommodative intercept closer to zero (p = 0.004) in males in the first 3 months as they relaxed accommodation more appropriately for distant targets. More females showed flat accommodation responses (p = 0.029). More males behaved hypermetropically in the first two months of life, but when these hypermetropic infants were excluded from the analysis, the gender difference remained. Gender differences disappeared after three months. Data showed variable responses and infants could behave appropriately and simultaneously on both, neither or only one measure at all ages. If accommodation was appropriate (gain between 0.7 and 1.3; r(2) > 0.7) but vergence was not, males over- and under-converged equally, while the females who accommodated appropriately were more likely to overconverge (p = 0.008). The apparent earlier maturity of the male accommodative responses may be due to refractive error differences but could also reflect gender-specific male preference for blur cues while females show earlier preference for disparity, which may underpin the earlier emerging, disparity dependent, stereopsis and full vergence found in females in other studies. 相似文献
59.
Heath A Kelly Heather F Gidding Theo Karapanagiotidis Jennie A Leydon Michaela A Riddell 《BMC public health》2007,7(1):99
Background
Past measles immunisation policies in Australia have resulted in a cohort of young adults who have been inadequately vaccinated, but who also have low levels of naturally acquired immunity because immunisation programs have decreased the circulation of wild virus. A measles-mumps-rubella (MMR) immunisation campaign aimed at addressing this susceptibility to measles among young adults was conducted in Australia in 2001–2. By estimating age-specific immunity, we aimed to evaluate the success of this campaign in the state of Victoria. 相似文献60.