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Atarashi H Kuruma A Yashima M Saitoh H Ino T Endoh Y Hayakawa H 《Clinical pharmacology and therapeutics》2000,68(2):143-150
OBJECTIVES: To elucidate pharmacokinetics and pharmacodynamics of landiolol hydrochloride, newer developed ultra-short-acting beta-blocker, in patients with various cardiac tachyarrhythmias. BACKGROUND: The short duration of action and titratability of landiolol hydrochloride make it ideal for use in patients with a clinical need for beta-blockers. METHODS: In a total of 31 examinations we infused the drug in 19 patients (mean age, 55 +/- 14 years). After the persistence of the tachyarrhythmias was confirmed, continuous infusion was started at rates of 0.005, 0.01, 0.02, 0.04, and 0.08 mg/kg/min for 5 minutes (for paroxysmal atrial fibrillation, paroxysmal supraventricular tachycardia, and ventricular tachycardia) or 15 minutes (for ventricular premature complex). We analyzed the pharmacokinetics of 16 examinations. A one-compartment model provided a close fit for each blood concentration-time curve. RESULTS: The maximum blood concentrations obtained clearly showed the dose dependency and revealed very short half-lives (range, 2.3 to 4.0 minutes). Area under the blood concentration-time curves also increased, showing dose dependency. In paroxysmal atrial fibrillation, landiolol hydrochloride reduced the heart rate from 111 +/- 20 to 90 +/- 10/min. Sinus rhythm was restored, without any adverse effects, in three of five patients with paroxysmal supraventricular tachycardia and one patient with ventricular tachycardia. There was no significant change in peripheral blood pressure. CONCLUSIONS: Landiolol hydrochloride has a shorter elimination half-life than any other beta-blocker, and it can be administered safely to patients with various tachyarrhythmias. 相似文献
105.
Abe T Terada T Noda R Hatano Y Nonaka T Kato N Sakurai H 《Journal of cardiac surgery》2010,25(6):683-685
We present a case of severe hemolysis following a mitral valve repair, which was successfully treated by removing the annuloplasty ring. The etiology of the hemolysis appeared to be a small regurgitant jet at the level of the annuloplasty ring. 相似文献
106.
Suguru Mizuno Kenji Hirano Minoru Tada Keisuke Yamamoto Yoko Yashima Hiroshi Yagioka Kazumichi Kawakubo Yukiko Ito Hirofumi Kogure Takashi Sasaki Toshihiko Arizumi Osamu Togawa Saburo Matsubara Yousuke Nakai Naoki Sasahira Takeshi Tsujino Hiroyuki Isayama Takao Kawabe Masao Omata Kazuhiko Koike 《Journal of gastroenterology》2010,45(7):758-762
Background
It is known that bezafibrate decreases serum alkaline phosphatase (ALP) in patients with hyperlipidemia, and the efficacy of this drug for the treatment of primary biliary cirrhosis has been confirmed. However, there has been little evidence of its efficacy for the treatment of primary sclerosing cholangitis (PSC).Methods
Bezafibrate (400 mg/day) was orally administered to 7 consecutive patients with PSC, and we analyzed their clinical features and the drug efficacy in terms of the effect on hepatobiliary enzymes, including ALP, gamma-glutamyl transpeptidase (γ-GTP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) after 6 months. The latest hepatobiliary enzyme levels were also evaluated.Results
In 3 patients (effective group), the levels of all hepatobiliary enzymes had decreased after 6 months. Mean ALP had decreased to approximately 40% of the baseline in this group. The efficacy of bezafibrate was observed for a long period (range, 8–27 months) in these 3 patients. There seemed to be no definite association between the efficacy of bezafibrate and the clinical features in the short term.Conclusions
This study showed that bezafibrate could lower the levels of hepatobiliary enzymes in about half of a cohort of patients with PSC. 相似文献107.
Yoh M Matsuyama J Shime A Okayama K Sakamoto R Honda T 《Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases》2010,84(5):583-587
Contaminated hospital linen has caused some cases of Bacillus cereus bacteremia in Japan. We analyzed the disinfection efficacy of industrial washing of hospital towels and sheets by counting the number of B. cereus on linen before and after washing. That before washing averaged 7.6 cells/cm2 on unwashed sheets, decreasing to 1.2 cells/cm2 after washing. That on unwashed towels, however, averaged 10(6) cells/cm2 before washing and 1096 cells/cm2 after washing, which was very high and suggested the possibility of causing nosocomial infection. 相似文献
108.
Hiroyuki Isayama Keisuke Yamamoto Suguru Mizuno Yoko Yashima Osamu Togawa Hirofumi Kogure Takashi Sasaki Naoki Sasahira Yousuke Nakai Kenji Hirano Takeshi Tsujino Minoru Tada Takao Kawabe Masao Omata 《Journal of Hepato-Biliary-Pancreatic Surgery》2009,16(3):270-273
Endoscopists seek to conduct more aggressive surgical procedures that surpass the limitations of existing endoscopic procedures.
Endoscopic pancreatic necrosectomy and natural orifice transluminal endoscopic surgery (NOTES) are typical examples of this
new trend; both are performed through the gastrointestinal wall without a skin incision. Endoscopic necrosectomy is effective
for managing organized pancreatic necrosis and abscesses. The necrotic tissues are removed endoscopically by directly entering
the cavity of the organized pancreatic necrosis. NOTES is a possible advance over surgical intervention, as it is a less invasive,
more cosmetic, and effective procedure. There are various approaches, including the esophagus, stomach, colon, and vagina;
Various procedures are possible using NOTES, such as cholecystectomy, appendectomy, full-thickness stomach resection, splenectomy,
gastrointestinal (GI) anastomosis, and peritoneoscopy. The requirements for NOTES include high proficiency in endoscopic techniques,
including knowledge of various devices, anatomy, and surgical procedures. Since most GI endoscopists have no surgical background,
to increase the usage of NOTES, GI endoscopists should form and lead teams that include various specialists. We believe that
endoscopic necrosectomy and NOTES represent a major shift in the treatment paradigm because physicians can treat beyond the
gastrointestinal wall and endoscopic procedures will replace surgical treatment. 相似文献
109.
Konghow Lee Masao Daimon Youichi Kuwabara Rei Hasegawa Tomohiko Toyoda Tai Sekine Takayuki Kawata Issei Komuro 《Journal of Echocardiography》2009,7(4):74-79