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61.
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Fábio S Lira José C Rosa Gustavo D Pimentel Victor AF Tarini Ricardo M Arida Flávio Faloppa Eduardo S Alves Cláudia O do Nascimento Lila M Oyama Marília Seelaender Marco T de Mello Ronaldo VT Santos 《Lipids in health and disease》2010,9(1):1-10
Introduction
Cytokines (IL-6, IL-10 and TNF-α) are increased after exhaustive exercise in the rat retroperitoneal (RPAT) and mesenteric adipose tissue (MEAT) pads. On the other hand, these cytokines show decreased expression in these depots in response to a chronic exercise protocol. However, the effect of exercise with overload combined with a short recovery period on pro- and anti-inflammatory cytokine expression is unknown. In the present study, we investigated the regulation of cytokine production in the adipose tissue of rats after an overtraining-inducing exercise protocol.Methods
Male Wistar rats were divided into four groups: Control (C), Trained (Tr), Overtrained (OT) and recovered overtrained (R). Cytokines (IL-6, TNF-α and IL-10) levels and Toll Like Receptor 4 (TLR4), Nuclear Factor kBp65 (NF-kBp65), Hormone Sensitive Lipase (HSL) and, Perilipin protein expression were assessed in the adipose tissue. Furthermore, we analysed plasma lipid profile, insulin, testosterone, corticosterone and endotoxin levels, and liver triacylglycerol, cytokine content, as well as apolipoprotein B (apoB) and TLR4 expression in the liver.Results
OT and R groups exhibited reduced performance accompanied by lower testosterone and increased corticosterone and endotoxin levels when compared with the control and trained groups. IL-6 and IL-10 protein levels were increased in the adipose tissue of the group allowed to recover, in comparison with all the other studied groups. TLR-4 and NF-kBp65 were increased in this same group when compared with both control and trained groups. The protein expression of HSL was increased and that of Perilipin, decreased in the adipose in R in relation to the control. In addition, we found increased liver and serum TAG, along with reduced apoB protein expression and IL-6 and IL-10 levels in the of R in relation to the control and trained groups.Conclusion
In conclusion, we have shown that increases in pro-inflammatory cytokines in the adipose tissue after an overtraining protocol may be mediated via TLR-4 and NF-kBp65 signalling, leading to an inflammatory state in this tissue. 相似文献63.
Adel Saad Helal El -Said Abdel-Hady Ehsan Refaie Maged El Shamy Raafat Abd El Fattah Abd El Magied Mashaly 《International journal of gynaecology and obstetrics》2010,108(3):233-235
Objective
To compare the effectiveness of preliminary uterine artery ligation versus pericervical mechanical tourniquet in reducing hemorrhage during myomectomy.Methods
A total of 103 patients undergoing myomectomy were randomly allocated to undergo preliminary uterine artery ligation (52 patients) or pericervical tourniquet (51 patients). The primary outcome measure was estimated blood loss. Secondary outcomes included duration of the operation, duration of hospital stay, postoperative hemoglobin, and the need for postoperative analgesia.Results
Operative blood loss was significantly less with uterine artery ligation compared with tourniquet (433.80 ± 285.21 vs 823.23 ± 237.33 mL, P < 0.001). The mean duration of the operation was lower in the uterine artery ligation group compared with the tourniquet group (50.5 ± 8.7 vs 76.3 ± 9.4 minutes, P < 0.001). Postoperative hospital stay was significantly shorter in the uterine artery ligation group compared with the tourniquet group (4.1 ± 0.1 vs 5.1 ± 0.2 days; P < 0.001). Postoperative hemoglobin concentrations and the need for postoperative analgesia were higher in the uterine artery ligation group (P = 0.012 and P < 0.001, respectively).Conclusion
Uterine artery ligation was more effective than pericervical tourniquet as a preliminary step in reducing blood loss during abdominal myomectomy. 相似文献64.
65.
Jeronimo A Nogueira Suzane K Ono-Nita Marcelo E Nita Marcelo MT de Souza Eliane P do Carmo Evandro S Mello Cristovan Scapulatempo Denise C Paranaguá-Vezozzo Flair J Carrilho Venancio AF Alves 《BMC cancer》2009,9(1):204
Background
Ser-249 TP53 mutation (249Ser) is a molecular evidence for aflatoxin-related carcinogenesis in Hepatocellular Carcinoma (HCC) and it is frequent in some African and Asian regions, but it is unusual in Western countries. HBV has been claimed to add a synergic effect on genesis of this particular mutation with aflatoxin. The aim of this study was to investigate the frequency of 249Ser mutation in HCC from patients in Brazil. 相似文献66.
D. Saragaglia S. Ruatti R. Refaie 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2013,23(4):431-436
The aim of this paper was to assess the impact on stability of revision of 29 standard acetabular cups to press-fit uncemented dual mobility (DM) cups in THAs with recurrent dislocation. This series was composed of 17 women and 12 men aged on average 75.6 ± 8.1 years (55–88), operated on between November 2000 and July 2010. The average number of dislocations before revision surgery was 3.87 ± 1.79 (2–10), and the average time from primary procedure to revision was 6.6 ± 4.3 years (45–15 years). 9 patients (31.03 %) had already undergone one or more procedures for instability prior to revision to DM cup. All patients were reviewed at an average time of 46 ± 28 months (range: 17 months–11 years). Only one patient had redislocated in this time (3.4 %). This patient underwent a simple closed reduction and did not dislocate again. Level of evidence: IV retrospective cohort study. 相似文献
67.
68.
Interleukin-5 is at 5q31 and is deleted in the 5q- syndrome 总被引:3,自引:0,他引:3
Sutherland GR; Baker E; Callen DF; Campbell HD; Young IG; Sanderson CJ; Garson OM; Lopez AF; Vadas MA 《Blood》1988,71(4):1150-1152
Human interleukin-5 (IL-5) is a selective eosinophilopoietic and eosinophil-activating growth hormone. By in situ hybridization this gene is mapped to chromosome 5q23.3 to 5q32. It is shown to be deleted in two patients with the 5q-syndrome and in one patient previously diagnosed with myelodysplasia whose condition had progressed to acute myeloblastic leukemia. The clustering of other genes involved in hematopoiesis (IL-3, granulocyte-macrophage colony-stimulating factor, feline sarcoma viral oncogene homolog, colony-stimulating factor 1) to the same region as IL-5 suggests a nonrandom localization and raises interesting questions concerning the evolution and regulation of these genes. 相似文献
69.
Extra-contractual referrals (ECRs) can be a cause of considerable anxiety to purchasing authorities, mainly because of their potential to generate unexpected expenditure. But ECRs can also be used as a tool for monitoring the demand for, and quality of, clinical services. ECRs were studied in the Darlington Health Authority district using a variety of methods including inter-disciplinary meetings, a series of interviews with local GPs, and a questionnaire to general practitioners on 230 consecutive ECRs. The methods and results of the questionnaire study are presented. The commonest reasons for making ECRs included the mistaken belief that a contract existed with the ECR provider, patient dissatisfaction with the local provider, and referral to benefit from shorter waiting lists. ECRs for bone-mass densitometry, orthopaedics, and ear nose and throat services were over-represented. Questionnaire results were validated by comparison with an interview study of all GPs in the district. We conclude that trends in ECRs can be monitored as a convenient ‘early warning system’ to alert purchasing authorities to changes in demand or perceived problems with local provider units. ECR data must be interpreted in the context of further local background information from sources such as GPs and public health physicians. In the case of Darlington, scrutiny of ECRs has led to changes in services and contracts. 相似文献
70.