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121.
Sabrina Ramwadhdoebe Godefridus G Van Merode Magda M Boere-Boonekamp Ralph JB Sakkers Erik Buskens 《BMC health services research》2010,10(1):75
Background
Implementation of medical interventions may vary with organization and available capacity. The influence of this source of variability on the cost-effectiveness can be evaluated by computer simulation following a carefully designed experimental design. We used this approach as part of a national implementation study of ultrasonographic infant screening for developmental dysplasia of the hip (DDH). 相似文献122.
123.
Extensive nodular cutaneous amyloidosis: an unusual presentation 总被引:2,自引:0,他引:2
PR Criado†‡ CS Silva† C Vasconcellos†‡ NYS Valente† JB Maito† 《Journal of the European Academy of Dermatology and Venereology》2005,19(4):481-483
Amyloidosis is characterized by the deposition of a group of unrelated proteins leading to changes in tissue architecture and function. The nodular variant is the rarest form of the cutaneous amyloidoses. We report a patient with localized nodular amyloidosis without systemic amyloid involvement or paraproteinaemia after 6 years of follow-up. The unusual aspects of our case were a plaque presentation rather than nodular, and the disseminated pattern observed. 相似文献
124.
125.
Stijn JB Van Weyenberg Sietze T Van Turenhout Maarten AJM Jacobs Gerd Bouma Chris JJ Mulder 《Digestive endoscopy》2012,24(4):247-254
Background and Aim: Little is known about the causes of overt obscure gastrointestinal bleeding (OGIB) in patients using anti‐thrombotic therapy. We aimed to describe video capsule endoscopy (VCE) findings and to identify factors associated with positive findings in these patients. Methods: We carried out a retrospective study of 56 patients who underwent VCE for evaluation of previous overt OGIB during anti‐thrombotic therapy. VCE studies were re‐evaluated by a gastroenterologist blinded to clinical details. Clinical data included in the multivariate analysis were sex, age, indication for and type of anti‐thrombotic therapy, hemodynamic instability on admission, type of blood loss, hemoglobin on admission, use of a proton pump inhibitor, NSAID use, time between bleeding episodes and VCE, and whether or not anti‐thrombotic therapy was resumed before the VCE study. Results: A probable cause for gastrointestinal bleeding was identified in 28 (50%) of the 56 studies. Angiodysplasia was found in 19 patients. Twenty‐two studies showed a possible cause in the small bowel. Multivariate logistic regression analysis showed that reinstitution of anti‐thrombotic therapy before VCE was carried out was the only independent predictor of positive VCE findings (OR: 8.61, 95% CI: 1.20–60.42, P = 0.032). Conclusions: Small intestinal angiodysplasia was the most common cause for overt OGIB. Reinstitution of withdrawn anti‐thrombotic drugs before the VCE examination was carried out was associated with positive VCE findings in multivariate analysis. 相似文献
126.
127.
128.
Walter JB; Brander C; Mammen M; Garboczi DN; Kalams SA; Whitesides GM; Walker BD; Eisen HN 《International immunology》1997,9(3):451-459
HLA-A2 heavy chain and beta 2-microglobulin were expressed in Escherichia
coli, and refolded in the presence of peptides derived from HIV-1 RT and
gag proteins. When recombinant HLA-A2 molecules were attached to cells
lacking HLA-A2, the cells became susceptible to lysis by HLA-A2-restricted
cytotoxic T lymphocyte (CTL) clones specific for peptides derived from RT
and gag proteins. Limiting dilution analyses of peripheral blood
mononuclear cells from HIV-1-infected individuals showed that the
recombinant HLA-A2 peptide complexes covalently immobilized on microspheres
stimulated the development of HLA-A2 peptide-specific CTL. Preformed
HLA-peptide complexes may provide an alternative to immunization procedures
that depend upon intracellular processing of antigen to elicit T cell
responses.
相似文献
129.
Doppman JL; Dedrick RL; Shook DR; Lutz RJ; Goldstein SR; Blacklock JB; Boretos JW; Paul RH; Austin HA d; Bowman RL 《Radiology》1986,159(2):477-483
Techniques have been developed for isolated perfusion of chemotherapeutic agents in patients with glioblastoma. Three catheters that facilitate crossing the carotid siphon have been developed; two are based on an everting or toposcopic principle, and one uses microjets for deflectability and improved mixing. Blood from the ipsilateral jugular vein is aspirated at high volumes (300 ml/min) for extracorporeal circulation through an adsorption column (for recovery of carmustine) or dialysers (for recovery of cisplatin). Preliminary experience in 10 patients suggests that high doses of chemotherapeutic agent can be administered using these catheters, with reduced retinal and systemic toxicity. 相似文献
130.
LUCIANO A FAVORITO CARLOS AB KLOJDA FRANCISCO JB SAMPAIO 《International journal of urology》2004,11(12):1110-1113
BACKGROUND: The aim of the present study is to make a comparative study in human fetuses and in patients with cryptorchidism, analyzing the incidence of a number anomalies of the testes for both populations. METHODS: We studied 326 testes from 163 human fetuses ranging in age from 10 to 35 weeks postconception (WPC) and 133 testes from 101 cryptorchid patients aged from 1 to 15 years old (mean, 6.4 years). The Fisher's exact test was used for comparison. RESULTS: Among 326 fetal testes, 224 (68.7%) were abdominal, 45 (13.8%) were inguinal and 55 (16.8%) were scrotal. In one fetus at 23 WPC, both testes (0.6%) were absent. Of the 133 cryptorchid testes, 17 (12.78%) were abdominal, 92 (69.1%) were inguinal and 24 (18%) were high scrotal. Of the 17 abdominal testes, three (17.6%) were atrophic and two were vanished (11.7%). Of the 92 inguinal testes, one (1.08%) was vanished. Twenty-eight (21%) of the cryptorchid testes were impalpable and among these, 17 were located in the abdomen (60.7%) and 11 (38.2%) in the inguinal region (internal ring). CONCLUSIONS: Testicular agenesis is a very rare anomaly, both in fetuses and patients with cryptorchidism. 相似文献