全文获取类型
收费全文 | 3133篇 |
免费 | 217篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 122篇 |
妇产科学 | 51篇 |
基础医学 | 371篇 |
口腔科学 | 67篇 |
临床医学 | 273篇 |
内科学 | 546篇 |
皮肤病学 | 75篇 |
神经病学 | 173篇 |
特种医学 | 197篇 |
外国民族医学 | 1篇 |
外科学 | 613篇 |
综合类 | 119篇 |
预防医学 | 219篇 |
眼科学 | 52篇 |
药学 | 198篇 |
中国医学 | 23篇 |
肿瘤学 | 253篇 |
出版年
2023年 | 28篇 |
2022年 | 77篇 |
2021年 | 120篇 |
2020年 | 70篇 |
2019年 | 69篇 |
2018年 | 83篇 |
2017年 | 56篇 |
2016年 | 73篇 |
2015年 | 107篇 |
2014年 | 112篇 |
2013年 | 147篇 |
2012年 | 202篇 |
2011年 | 225篇 |
2010年 | 116篇 |
2009年 | 129篇 |
2008年 | 181篇 |
2007年 | 197篇 |
2006年 | 163篇 |
2005年 | 158篇 |
2004年 | 137篇 |
2003年 | 105篇 |
2002年 | 94篇 |
2001年 | 78篇 |
2000年 | 61篇 |
1999年 | 41篇 |
1998年 | 34篇 |
1997年 | 54篇 |
1996年 | 35篇 |
1995年 | 43篇 |
1994年 | 22篇 |
1993年 | 16篇 |
1992年 | 25篇 |
1991年 | 21篇 |
1990年 | 22篇 |
1989年 | 22篇 |
1988年 | 20篇 |
1987年 | 23篇 |
1986年 | 16篇 |
1985年 | 19篇 |
1984年 | 14篇 |
1983年 | 23篇 |
1982年 | 14篇 |
1981年 | 13篇 |
1980年 | 13篇 |
1979年 | 14篇 |
1978年 | 9篇 |
1977年 | 13篇 |
1976年 | 10篇 |
1975年 | 17篇 |
1974年 | 9篇 |
排序方式: 共有3374条查询结果,搜索用时 31 毫秒
101.
Masood Umer Kashif Abbas Shahid Khan Haroon ur Rashid 《Clinics in Orthopedic Surgery》2013,5(4):321-326
Background
We are presenting our experience in the use of locking compression plate (LCP) after juxta-articular oncological resections in addition to its use in pathologic fracture.Methods
A retrospective audit of skeletal reconstruction using LCP in 25 cases of long bone tumors was performed from 2008 to 2010. Reconstruction following limb salvage surgery was done in 17 patients and internal fixation of pathological fracture was done in 8 patients. All patients were available for > 12 months of follow-up, and thus assessed for union at the resected ends.Results
There were 8 males and 17 females in the study. The average age at the time of surgery was 30 years (range, 9 to 66 years). The minimum follow-up was 12 months (range, 12 to 32 months). All patients except three went on to heal successfully. Complications occurred in those three patients: wound infection in one, nonunion in another, and periprosthetic fracture in the other patient. In the remaining patients, union was achieved at an average of 6.5 months after reconstruction in curative resection and 4.75 months after fixation of pathological fractures.Conclusions
Joint sparing limb salvage surgery was made successfully possible after sekeletal reconstruction with LCP. Its use was also quite effective in pathological fractures with poor bone quality. Use of locking plates for musculoskeletal oncological reconstruction resulted in a good and predictable rate of union. 相似文献102.
David I. Wasserman Haoran G. Wang Asim J. Rashid Sheena A. Josselyn John S. Yeomans 《The European journal of neuroscience》2013,38(5):2774-2785
M5 muscarinic acetylcholine receptors expressed on ventral tegmental dopamine (DA) neurons are needed for opioid activation of DA outputs. Here, the M5 receptor gene was bilaterally transfected into neurons in the ventral tegmental area (VTA) or the adjacent rostromedial tegmental nucleus (RMTg) in mice by means of a Herpes simplex viral vector (HSV) to increase the effect of endogenous acetylcholine. Three days after HSV‐M5 gene infusion in VTA sites, morphine‐induced locomotion more than doubled at two doses, while saline‐induced locomotion was unaffected. When the HSV‐M5 gene was infused into the adjacent RMTg, morphine‐induced locomotion was strongly inhibited. The sharp boundary between these opposing effects was found where tyrosine hydroxylase (TH) and cholinesterase labelling decreases (?4.00 mm posterior to bregma). The same HSV‐M5 gene transfections in M5 knockout mice induced even stronger inhibitory behavioural effects in RMTg but more variability in VTA sites due to stereotypy. The VTA sites where HSV‐M5 increased morphine‐induced locomotion receive direct inputs from many RMTg GAD‐positive neurons, and from pontine ChAT‐positive neurons, as shown by cholera‐toxin B retrograde tracing. Therefore, morphine‐induced locomotion was decreased by M5 receptor gene expression in RMTg GABA neurons that directly inhibit VTA DA neurons. Conversely, enhancing M5 receptor gene expression on VTA DA neurons increased morphine‐induced locomotion via cholinergic inputs. 相似文献
103.
104.
Utility of early influenza diagnosis through point‐of‐care testing in children presenting to an emergency department
下载免费PDF全文
![点击此处可从《Journal of paediatrics and child health》网站下载免费的PDF全文](/ch/ext_images/free.gif)
105.
Svetlana Bozhkova Rashid Tikhilov Dmitry Labutin Alexey Denisov Igor Shubnyakov Vadim Razorenov Vasilii Artyukh Anna Rukina 《Journal of orthopaedics and traumatology》2016,17(4):369-376
Background
The unsuccessful treatment of prosthetic joint infection (PJI) with two-stage revision leads to infection recurrence. The objectives of the study were to assess the clinical and demographic characteristics of patients with polymicrobial PJI, and to evaluate the role of the microbial profile involved in PJI in the risk of infection recurrence after the first step of two-stage revision surgery.Materials and methods
A retrospective analysis of 189 cases of culture-positive PJI following total hip replacement over a 5-year period was performed. The demographic characteristics of patients, clinical symptoms, microbiology cultures of intraoperative biopsies, laboratory values of C-reactive protein (CRP), white blood cell count and erythrocyte sedimentation rate were analyzed. Patients were divided into two groups—135 with monomicrobial and 54 with polymicrobial infection.Results
Of all patients, 68.9 % in the monomicrobial and 83.3 % in the polymicrobial group had a body mass index >25 kg/m2 (p = 0.05). The median CRP values were 5.7 mg/L (IQR 4.0–10.0 mg/L) in the monomicrobial compared to 8.8 mg/L (IQR 5.0–27 mg/L) in the polymicrobial group (p = 0.01). The percentage of successful outcomes was 27.8 % in patients with microbial associations (p < 0.0001). Gram-negative pathogens caused polymicrobial PJI in 61.5 % of cases with infection recurrence (OR 4.4; 95 % CI 1.18–16.37; p = 0.03).Conclusions
Overweight and obese patients or those with elevated CRP had a greater risk of polymicrobial PJI. They were predisposed to recurrence of infection after the first step of two-stage revision. An unsuccessful outcome was more likely in cases with polymicrobial infection compared to those with monomicrobial infection. In addition, the presence of multidrug-resistant strains of Gram-negative bacteria substantially increased the risk of PJI treatment being unsuccessful.Level of evidence
Level III, therapeutic study.106.
107.
108.
109.
110.
What advice is given to newly qualified doctors on Twitter? An analysis of #TipsForNewDocs tweets
下载免费PDF全文
![点击此处可从《Medical education》网站下载免费的PDF全文](/ch/ext_images/free.gif)