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11.
Shrikala Acharya Maninder Singh Setia Amol Palkar Dandu Chandra Sekar Reddy Padmaja Keskar Pramod Deoraj Mugundu Ramien Parthasarthy Padum Narayan Shobhini Rajan Alok Saxena 《The International journal of health planning and management》2021,36(1):71-82
A key recommendation of the National AIDS Control Programme‐IV of India was to develop new strategies for geo‐prioritization of the human immunodeficiency virus (HIV) epidemic. We conducted this study to categorize the districts in Maharashtra (India) based on a multidimensional framework for geo‐prioritization of services. Programmatic data on trends of HIV prevalence, coverage of marginalized populations and vulnerability factors were included. A composite indicator based on these was developed, and the cumulative score was calculated for each district. HIV prevalence among general population has declined steadily from 0.60% in 2007 to 0.33% in 2017. The programme coverage was stable but inadequate for men who have sex with men (MSM). The coverage for female sex workers (FSWs) was inadequate and reduced over time. Nine districts were categorized as high priority, 13 as moderate priority and 11 were classified as low‐priority districts based on burden and vulnerability for HIV. The high‐priority districts were Pune, Solapur and Yavatmal for FSW interventions and Pune, Thane and Latur for MSM interventions. This multidimensional indicator is based on existing programmatic data, dynamic and can be made state‐specific. It is useful to categorize and prioritize districts for allocation of resources and geo‐prioritization of services in resource limited settings. 相似文献
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Vallabhaneni S Nair BC Cortez V Challa R Chakravarty D Tekmal RR Vadlamudi RK 《Breast cancer research and treatment》2011,130(2):377-385
The estrogen receptor (ER) is implicated in the progression of breast cancer. Despite positive effects of hormonal therapy,
initial or acquired resistance to endocrine therapies frequently occurs. Recent studies suggested ERα-coregulator PELP1 and
growth factor receptor ErbB2/HER2 play an essential role in hormonal therapy responsiveness. Src axis couples ERα with HER2
and PELP1, thus representing a new pathway for targeted therapy resistance. To establish the significance of ER–Src axis in
PELP1 and HER2 mediated therapy resistance, we have generated model cells that stably express Src-shRNA under conditions of
PELP1, HER2 deregulation. Depletion of Src using shRNA substantially reduced E2 mediated activation of Src and MAPK activation
in resistant model cells. Pharmacological inhibition of Src using dasatinib, an orally available inhibitor substantially inhibited
the growth of therapy resistant MCF7–PELP1, MCF7–HER2, and MCF7–Tam model cells in proliferation assays. In post-menopausal
xenograft based studies, treatment with dasatinib significantly inhibited the growth of therapy resistant cells. IHC analysis
revealed that the tumors were ERα positive, and dasatinib treated tumors exhibited alterations in Src and MAPK signaling pathways.
Combinatorial therapy of tamoxifen with dasatinib showed better therapeutic effect compared to single agent therapy on the
growth of therapy resistant PELP1 driven tumors. The results from our study showed that ER–Src axis play an important role
in promoting hormonal resistance by proto-oncogenes such as HER2, PELP1, and blocking this axis prevents the development of
hormonal independence in vivo. Since PELP1, HER2, and Src kinase are commonly deregulated in breast cancers, combination therapies
using both endocrine agents and dasatinib may have better therapeutic effect by delaying the development of hormonal resistance. 相似文献
13.
Venkateswarlu S Ramachandra MS Rambabu M Subbaraju GV 《Journal of Asian natural products research》2000,2(2):111-120
A general and straight forward total synthesis of 1,7-bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadiene-5-one (5) starting from 4-methoxycinnamic acid (6) via ethyl 5-(4-methoxyphenyl)-3-hydroxy-2,4-pentadienoate (14) was accomplished in 19% overall yield. 相似文献
14.
Silakari P Shrivastava SD Silakari G Kohli DV Rambabu G Srivastava S Shrivastava SK Silakari O 《European journal of medicinal chemistry》2008,43(7):1559-1569
Quantitative structure-activity relationship (QSAR) analysis was performed on a series of 1,3-diaryl-4,5,6,7-tetrahydro-2H-isoindole for their cyclooxygenase-2 (COX-2) inhibition. QSAR investigations were based on Hansch's extra thermodynamic multi-parameter approach and receptor surface analysis (RSA). QSAR investigations reveal that steric and electrostatic interactions are primarily responsible for COX-2 enzyme-ligand interaction. QSAR model derived from Hansch analysis demonstrated that COX-2 inhibitory activity is correlated with sum of atomic polarizability (Apol), number of hydrogen-bond donor groups (HBD), energy of the highest occupied molecular orbital (HOMO), desolvation free energy for water (F(H(2)O)) and fraction of areas of molecular shadow in the XY and ZX planes over area of enclosing rectangle (Sxyf and Sxzf) with r ranges 0.870-0.904. The best model was obtained from RSA model having r = 0.940 with good predictive ability (predicted compounds in training set and test set within +/- 1.0 unit of pIC(50)) and can be used in designing better selective COX-2 inhibitors among the congeners in future. 相似文献
15.
Morten A. Karsdal Samuel J. Daniels Signe Holm Nielsen Cecilie Bager Daniel G.K. Rasmussen Rohit Loomba Rambabu Surabattula Ida Falk Villesen Yi Luo Diane Shevell Natasja S. Gudmann Mette J. Nielsen Jacob George Rose Christian Diana J. Leeming Detlef Schuppan 《Liver international》2020,40(4):736-750
There is an unmet need for high‐quality liquid biomarkers that can safely and reproducibly predict the stage of fibrosis and the outcomes of chronic liver disease (CLD). The requirement for such markers has intensified because of the high global prevalence of diseases such as non‐alcoholic fatty liver disease (NAFLD). In particular, there is a need for diagnostic and prognostic tools, as well as predictive biomarkers that reflect the efficacy of interventions, as described by the BEST criteria (Biomarkers, EndpointS, and other Tools Resource). This review covers the various liver collagens, their functional role in tissue homeostasis and delineates the common nomenclature for biomarkers based on BEST criteria. It addresses the common confounders affecting serological biomarkers, and describes defined collagen epitope biomarkers that originate from the dynamic processes of extracellular matrix (ECM) remodelling during liver injury. 相似文献
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Timur Liwinski Sina Hübener Lara Henze Peter Hübener Melina Heinemann Marcus Tetzlaff Marie I. Hiller Bettina Jagemann Rambabu Surabattula Diana Leeming Morten Karsdal Erika Monguzzi Guido Schachschal Thomas Rösch Corinna Bang Andre Franke Ansgar W. Lohse Detlef Schuppan Christoph Schramm 《Alimentary pharmacology & therapeutics》2023,57(2):224-236
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