全文获取类型
收费全文 | 5704篇 |
免费 | 255篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 34篇 |
儿科学 | 240篇 |
妇产科学 | 79篇 |
基础医学 | 530篇 |
口腔科学 | 107篇 |
临床医学 | 422篇 |
内科学 | 1260篇 |
皮肤病学 | 179篇 |
神经病学 | 414篇 |
特种医学 | 184篇 |
外科学 | 984篇 |
综合类 | 109篇 |
预防医学 | 236篇 |
眼科学 | 280篇 |
药学 | 500篇 |
1篇 | |
中国医学 | 36篇 |
肿瘤学 | 384篇 |
出版年
2024年 | 2篇 |
2023年 | 38篇 |
2022年 | 117篇 |
2021年 | 212篇 |
2020年 | 106篇 |
2019年 | 144篇 |
2018年 | 166篇 |
2017年 | 119篇 |
2016年 | 168篇 |
2015年 | 186篇 |
2014年 | 274篇 |
2013年 | 368篇 |
2012年 | 524篇 |
2011年 | 521篇 |
2010年 | 278篇 |
2009年 | 244篇 |
2008年 | 389篇 |
2007年 | 405篇 |
2006年 | 376篇 |
2005年 | 322篇 |
2004年 | 315篇 |
2003年 | 232篇 |
2002年 | 180篇 |
2001年 | 37篇 |
2000年 | 36篇 |
1999年 | 34篇 |
1998年 | 26篇 |
1997年 | 27篇 |
1996年 | 19篇 |
1995年 | 19篇 |
1994年 | 16篇 |
1993年 | 19篇 |
1992年 | 7篇 |
1991年 | 10篇 |
1990年 | 13篇 |
1989年 | 7篇 |
1988年 | 4篇 |
1987年 | 6篇 |
1986年 | 1篇 |
1985年 | 5篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 3篇 |
1980年 | 1篇 |
1979年 | 1篇 |
排序方式: 共有5979条查询结果,搜索用时 124 毫秒
131.
132.
Monica Juneja Devendra Mishra Paul S. S. Russell Sheffali Gulati Vaishali Deshmukh Poma Tudu Rajesh Sagar Donald Silberberg Vinod K. Bhutani Jennifer M. Pinto Maureen Durkin Ravindra M. Pandey Mkc Nair Narendra K. Arora 《Indian pediatrics》2014,51(5):359-365
Objective
To develop and validate INCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD).Design
Diagnostic test evaluation by cross sectional designSetting
Four tertiary pediatric neurology centers in Delhi and Thiruvanthapuram, India.Methods
Children aged 2–9 years were enrolled in the study. INDT-ASD and Childhood Autism Rating Scale (CARS) were administered in a randomly decided sequence by trained psychologist, followed by an expert evaluation by DSM-IV TR diagnostic criteria (gold standard).Main outcome measures
Psychometric parameters of diagnostic accuracy, validity (construct, criterion and convergent) and internal consistency.Results
154 children (110 boys, mean age 64.2 mo) were enrolled. The overall diagnostic accuracy (AUC=0.97, 95% CI 0.93, 0.99; P<0.001) and validity (sensitivity 98%, specificity 95%, positive predictive value 91%, negative predictive value 99%) of INDT-ASD for Autism spectrum disorder were high, taking expert diagnosis using DSM-IV-TR as gold standard. The concordance rate between the INDT-ASD and expert diagnosis for’ ASD group’ was 82.52% [Cohen’s κ=0.89; 95% CI (0.82, 0.97); P=0.001]. The internal consistency of INDT-ASD was 0.96. The convergent validity with CARS (r = 0.73, P= 0.001) and divergent validity with Binet-Kamat Test of intelligence (r = ?0.37; P=0.004) were significantly high. INDT-ASD has a 4-factor structure explaining 85.3% of the variance.Conclusion
INDT-ASD has high diagnostic accuracy, adequate content validity, good internal consistency high criterion validity and high to moderate convergent validity and 4-factor construct validity for diagnosis of Autistm spectrum disorder. 相似文献133.
Sasidharan Rajesh Tom George Cyriac Abby Philips Rizwan Ahamed Sandeep Kumbar Narain Mohan Meera Mohanan Philip Augustine 《World journal of gastroenterology : WJG》2020,26(37):5561-5596
More than five decades after it was originally conceptualized as rescue therapy for patients with intractable variceal bleeding, the transjugular intrahepatic portosystemic shunt(TIPS) procedure continues to remain a focus of intense clinical and biomedical research. By the impressive reduction in portal pressure achieved by this intervention, coupled with its minimally invasive nature, TIPS has gained increasing acceptance in the treatment of complications of portal hypertension. The early years of TIPS were plagued by poor long-term patency of the stents and increased incidence of hepatic encephalopathy. Moreover, the diversion of portal flow after placement of TIPS often resulted in derangement of hepatic functions, which was occasionally severe. While the incidence of shunt dysfunction has markedly reduced with the advent of covered stents, hepatic encephalopathy and instances of early liver failure continue to remain a significant issue after TIPS. It has emerged over the years that careful selection of patients and diligent post-procedural care is of paramount importance to optimize the outcome after TIPS. The past twenty years have seen multiple studies redefining the role of TIPS in the management of variceal bleeding and refractory ascites while exploring its application in other complications of cirrhosis like hepatic hydrothorax, portal hypertensive gastropathy, ectopic varices, hepatorenal and hepatopulmonary syndromes, non-tumoral portal vein thrombosis and chylous ascites. It has also been utilized to good effect before extrahepatic abdominal surgery to reduce perioperative morbidity and mortality. The current article aims to review the updated literature on the status of TIPS in the management of patients with liver cirrhosis. 相似文献
134.
Glycemic control in hospitalized patients with diabetes requires accurate near-patient glucose monitoring systems. In the past decade, point-of-care blood glucose monitoring devices have become the mainstay of near-patient glucose monitoring in hospitals across the world. In this article, we focus on its history, accuracy, clinical use, and cost-effectiveness. Point-of-care devices have evolved from 1.2 kg instruments with no informatics to handheld lightweight portable devices with advanced connectivity features. Their accuracy however remains a subject of debate, and new standards for their approval have now been issued by both the International Organization for Standardization and the Clinical and Laboratory Standards Institute. While their cost-effectiveness remains to be proved, their clinical value for managing inpatients with diabetes remains unchallenged. This evidence-based review provides an overall view of its use in the hospital setting. 相似文献
135.
P. V. M. Lakshmi Atul Sharma Deepak Bhatia Kulbhushan Tikoo Rajesh Kumar 《The American journal of tropical medicine and hygiene》2014,91(4):786-789
Epidemic dropsy is caused by consumption of mustard oil contaminated with argemone oil. It usually occurs in outbreaks with acute manifestation of bilateral pitting edema, erythema, and local tenderness along with cardiac and respiratory problems in severe cases leading to death. We report an outbreak that is unusual because of its gradual onset, clustering in a single family, and with major manifestation of gastrointestinal illness mimicking acute gastroenteritis, hence leading to delayed diagnosis and high mortality. Thus, the diagnosis of epidemic dropsy should be considered as a strong possibility when there is clustering of cases in a single family with on and off gastrointestinal symptoms of vomiting and diarrhea in a mustard oil consuming belt. 相似文献
136.
137.
Gopalan Nair Rajesh Kalathingathodika Sajeer Anishkumar Nair Chakanalil Govindan Sajeev Mangalath Narayanan Krishnan 《Indian heart journal》2014,66(3):370-371
Hammock valve, also known as anomalous mitral arcade is a rare mechanism for congenital mitral insufficiency. We report a case of a two-week-old neonate who presented with features of heart failure and an apical systolic murmur. Echocardiogram showed severe mitral regurgitation and abnormal mitral valve with direct attachment of mitral leaflets to papillary muscle without intervening chordae tendinae, typical of hammock valve. Heart failure was controlled with ionotrpes and diuretics. The literature on the hammock mitral valve is reviewed. 相似文献
138.
Ketoprofen belongs to one of the most common nonsteroidal anti‐inflammatory drugs (NSAIDs) but its clinical usefulness has been restricted due to the high incidence of gastrointestinal complications. The release of reactive oxygen species (ROS) in NSAIDs therapy plays a major role in causing gastric complications. Antioxidants not only prevent gastric ulceration and lipid peroxidation but also preserve glutathione‐type peroxidase (GPO) activity. Therefore, the present study investigates the utility of combining anti‐inflammatory and antioxidant properties of two different compounds in a single molecule to form a series of 16 ketoprofen–antioxidant mutual codrugs. The free carboxylic group, which is believed to be one of the reasons for gastric toxicity of ketoprofen, was masked temporarily by simple and double esterification with alcoholic/phenolic–OH of natural antioxidants. In simple esterification, ketoprofen is directly linked to natural antioxidants ( IIa–h ) in the hope to obtain drugs free of gastric side effects. In an attempt to improve the in vivo lability, as well as gastric side effects, the double ester codrugs, that is, ketoprofen–antioxidant through the glycolic acid spacer (–CH2COO; IIIa–h ), have also been designed and synthesized. The synthesized codrugs were characterized by IR, 1H NMR, 13C NMR, mass spectroscopy and elemental analysis. The in vitro hydrolysis studies showed the lowest hydrolysis (highest stability) in acidic pH 1.2, whereas moderate hydrolysis was seen at pH 7.4 and significant hydrolysis in 80% human blood plasma, as indicated by their t1/2. The pharmacological evaluation results indicate that these ketoprofen–antioxidant mutual codrugs showed the retention of anti‐inflammatory and analgesic activity with a significant reduction in the ulcer index. 相似文献
139.
140.