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131.
PPARgamma inhibits GH synthesis and secretion and increases apoptosis of pituitary GH-secreting adenomas 总被引:4,自引:0,他引:4
132.
Lucas Bet da Rosa Orssatto Ewertton de Souza Bezerra Bruno Monteiro de Moura João Antônio Chula de Castro Diego Augusto Santos Silva Antônio Renato Pereira Moro Fernando Diefenthaeler 《Journal of bodywork and movement therapies》2018,22(3):586-591
The aims of this pilot study were to verify which muscle strength tests better explain bone mineral content (BMC) of the femoral neck and lumbar spine and to develop predictive equations to estimate femoral neck and lumbar spine BMC. Twenty-nine subjects aged 56–76 years old (12 women and 17 men) participated in the study. Femoral neck and lumbar spine BMC was evaluated by Dual X-ray absorptiometry (DXA). Muscle strength measurements included maximal isometric voluntary contractions of knee extensors and flexors, vertical jump, 5-repetition maximum of the leg press (5-RMLP) and seated leg curl (5-RMLC), and handgrip strength. Women presented a moderate to strong correlation between femoral neck BMC and 5-RMLP (r = 0.819), 5-RMLC (r = 0.879), knee extensors peak torque (r = 0.699), and handgrip strength (r = 0.663), as well as between lumbar spine BMC and the 5-RMLP test (r = 0.845) and manual grip strength (r = 0.699). For females, the 5-RMLP and 5-RMLC tests most fully explained femoral neck BMC (R2 = 0.859) and the 5-RMLP test and body mass explained lumbar spine density (R2 = 0.757) for females. Men did not present correlations between BMC and strength variables. For females, the 5-RMLP and 5-RMLC variables explained the variations of femoral neck BMC, while 5-RMLP and body mass explained lumbar spine BMC. Future studies should evaluate a larger sample size and prioritize the strength tests with a greater predictive capacity. 相似文献
133.
134.
Oral Prolonged‐Release Oxycodone/Naloxone for Managing Pain and Opioid‐Induced Constipation: A Review of the Evidence
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Bart J. Morlion PhD Stefan A. Mueller‐Lissner MD Renato Vellucci PGDip Wojciech Leppert MD Benoît C. Coffin MD PhD Sara L. Dickerson MSc Tony O'Brien FRCPI 《Pain practice》2018,18(5):647-665
Background
Opioids provide effective relief from moderate‐to‐severe pain and should be prescribed as part of a multifaceted approach to pain management when other treatments have failed. Fixed‐dose oxycodone/naloxone prolonged‐release tablets (OXN PR) were designed to address the opioid class effect of opioid‐induced constipation (OIC) by combining the analgesic efficacy of oxycodone with the opioid receptor antagonist, naloxone, which has negligible systemic availability when administered orally. This formulation has abuse‐deterrent properties, since systemic exposure to naloxone by parenteral administration would antagonize the euphoric effects of oxycodone.Methods
A literature search was conducted to assess the evidence base for OXN PR to treat moderate‐to‐severe pain and its impact on bowel function, based on published clinical trials and observational studies.Results
Extensive data demonstrate that OXN PR provides effective analgesia and clinically relevant improvements in bowel function in patients with OIC and moderate‐to‐severe cancer‐related pain and noncancer pain types such as low back pain, neuropathic pain, and musculoskeletal pain. OXN PR has also been found to improve bowel function in patients with OIC refractory to multiple types of laxatives, and improve Parkinson's disease–related pain. No unanticipated safety concerns have been reported in elderly patients.Conclusions
Evidence from clinical trials and observational studies confirms that for selected patients OXN PR significantly improves moderate‐to‐severe chronic pain and provides relief from OIC. Treatment should be tailored to individual patients to establish the lowest effective dose. An absence of analgesic ceiling effect was seen across the clinically relevant dose range investigated (≤ 160/80 mg/day). 相似文献135.
Alon Unger Ridalva D. M. Felzemburgh Robert E. Snyder Guilherme S. Ribeiro Sharif Mohr Vinícius B. A. Costa Astrid X. T. O. Melendez Renato B. Reis Francisco S. Santana Lee W. Riley Mitermayer G. Reis Albert I. Ko Pau da Lima Urban Health Team 《Journal of urban health》2015,92(3):446-459
Low- and middle-income countries account for the majority of hypertension disease burden. However, little is known about the distribution of this illness within subpopulations of these countries, particularly among those who live in urban informal settlements. A cross-sectional hypertension survey was conducted in 2003 among 5649 adult residents of a slum settlement in the city of Salvador, Brazil. Hypertension was defined as either an elevated arterial systolic (≥140 mmHg) or diastolic (≥90 mmHg) blood pressure. Sex-specific multivariable models of systolic blood pressure were constructed to identify factors associated with elevated blood pressure. The prevalence of hypertension in the population 18 years and older was 21 % (1162/5649). Men had 1.2 times the risk of hypertension compared with women (95 % confidence intervals (CI), 1.05, 1.36). Increasing age and lack of any schooling, particularly for women, were also significantly associated with elevated blood pressure (p < 0.05). There was also a direct association between men who were black and an elevated blood pressure. Among those who were hypertensive, 65.5 % were aware of their condition, and only 36.3 % of those aware were actively using anti-hypertensive medications. Men were less likely to be aware of their diagnosis or to use medications (p < 0.01 for both) than women. The prevalence of hypertension in this slum community was lower than reported frequencies in the non-slum population of Brazil and Salvador, yet both disease awareness and treatment frequency were low. Further research on hypertension and other chronic non-communicable diseases in slum populations is urgently needed to guide prevention and treatment efforts in this growing population. 相似文献
136.
137.
Vale Paula D. Silva Livia T. M. de Oliveira Edna Maria M. de Miranda Ricardo F. C. da Silva Renato David Araújo Lielia M. C. da Silva Samuel M. P. Cunha Wanessa C. Neto José S. Péres Ayrton K. Seixas Tamer N. da Rocha Jairo M. Margalho Carla S. Maia Henrique Cesar de A. 《Journal of interventional cardiac electrophysiology》2022,63(2):425-430
Journal of Interventional Cardiac Electrophysiology - Delineate retrospectively and prospectively the incidence and characteristics of transient ST-segment elevation during transseptal puncture.... 相似文献
138.
Evaluation of breast tumour cell contamination in the bone marrow and leukapheresis collections by RT-PCR for cytokeratin-19 mRNA 总被引:5,自引:0,他引:5
139.
Renato Pasquali Paola Biso Giovanna Baraldi Loretta Mattioli Maurizio Capelli Francesca Pasqui Nazario Melchionda 《Acta diabetologica》1983,20(2):153-161
Summary In this study, we evaluated in normal subjects, insulin-dependent (IDD) and non-insulin-dependent (NIDD) diabetics, the diurnal
urinary C-peptide excretion rate (CPR-U) and its relationship to serum C-peptide concentration and glucose:C-peptide molar
ratio, and to the common parameters of metabolic control. The CPR-U (and CPR-U/g creatinine) were significantly lower in IDD
and higher in NIDD compared to control subjects. Moreover, a good and significant correlation with serum C-peptide concentrations
and the glucose:C-peptide ratio in diabetic subjects as well as in controls and diabetics considered together was found. A
slight but significant correlation was present in diabetic subjects between CPR-U and body mass index (r=0.45), 24-h glycosuria
(r=−0.36), HbA1 levels (r=−0.31), post-prandial glucose concentrations (r=−0.26) and per cent glucose variation after each
meal (r=−0.34). No differences were found in CPR-U and the degree of metabolic control between obese and non-obese NIDD. In
conclusion, CPR-U may be a useful and simple method of defining the secretory activity of the B-cell. Metabolic control in
diabetics is slightly correlated to the degree of B-cell function as evaluated by the diurnal excretion rate of C-peptide
in urine.
Part of this paper was presented at the National Meeting of the Italian Diabetes Association, Bari, May 27–29, 1982. 相似文献
140.
P-glycoprotein, lung resistance-related protein and multidrug resistance-associated protein in de novo adult acute lymphoblastic leukaemia 总被引:7,自引:0,他引:7
Damiani D Michelutti A Michieli M Masolini P Stocchi R Geromin A Ermacora A Russo D Fanin R Baccarani M 《British journal of haematology》2002,116(3):519-527
P-glycoprotein (P-gp), lung resistance-related protein (LRP) and multidrug resistance-associated protein (MRP) expression, and blast cell intracellular daunorubicin accumulation (IDA) were evaluated in 95 previously untreated cases of adult acute lymphoblastic leukaemia (ALL) using flow cytometry. Forty-five out of 95 (47%) patients were P-gp positive (+), 12/66 (18%) were LRP+ and 11/66 (17%) were MRP+. Eighteen out of 66 (28%) patients showed a simultaneous multidrug resistance (MDR)-related protein expression higher than controls for more than one protein, while 24/66 (36%) cases did not overexpress any protein. Twenty-one out of 24 (87%) cases overexpressing at least one MDR-related protein had a defect in accumulating daunorubicin into their blast cells, while only 4/24 (16%) cases who did not overexpress any protein had similar features. The complete remission rates were similar in MDR-positive and -negative (-) patients but relapses within 6 months were more frequent in P-gp+ cases, and therefore the disease-free survival duration was shorter in P-gp+ than in P-gp- patients (P = 0.01). The number of MRP+ and/or LRP+ cases was too small to be able to draw any conclusion on their role in affecting or predicting therapy outcome. In conclusion, P-gp overexpression associated with a defect in daunorubicin accumulation is a frequent feature in adult ALL at onset and seems to be related to poorer therapy outcome and, consequently, a shorter disease-free survival. LRP and MRP overexpression seems to be a rare event and no conclusion can be drawn on its prognostic role. 相似文献