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Calorini L Bianchini F Mannini A Mugnai G Balzi M Becciolini A Ruggieri S 《Clinical & experimental metastasis》2002,19(3):259-264
In the present study, we found that murine peritoneal macrophages elicited by BCG or Listeria monocytogenes release into the media an activity capable of stimulating the lung colonization as well as the expression of MHC class I
antigens in B16 melanoma cells. A similar activity has previously been found in media conditioned by Corynebacterium parvum-elicited macrophages. Analysis by gel filtration chromatography of media conditioned by Corynebacterium parvum-, BCG- or Listeria monocytogenes-elicited macrophages revealed that the material responsible for the pro-clonogenic activity concentrated in chromatographic
fractions corresponding to molecular weights (25 to 52 kDa) which are characteristic of certain cytokines. Thus, we challenged
the various macrophage-conditioned media with polyclonal antibodies against IFNγand TNFα, and found that the macrophage pro-clonogenic
activity was completely abolished in the presence of anti-IFNγantibodies, but only partially inhibited by anti-TNFαantibodies.
This finding suggests a cooperative participation of the two cytokines to the pro-clonogenic activity of the media conditioned
by Corynebacterium parvum-, BCG- or Listeria monocytogenes-elicited macrophages.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
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Macchi C Popolizio A Casamorata F Bicchi S Pieroni A Molino Lova R Miniati B Gulisano M Catini C Conti AA Gensini GF 《Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia》2002,107(2):93-97
Fifty-four subjects, aged between 20 and 35 years, divided into two subgroups, respectively 30 healthy subjects (17 males and 13 females) and 24 subjects with "gonalgia sine materia" (13 males and 11 females) underwent isokinetic exercise test in order to compare their dominant limb with the not dominant one as regard as the strength of extensor and flexor muscles of the knee. No statistically significant difference was found in any of the studied parameters in the comparison between the dominant limb and the not dominant one, both within the subgroup of healthy subjects and within the subgroup of subjects with "gonalgia sine materia". Authors conclude that psychological features may play a preeminent role in the genesis, as well as in the maintenance of "gonalgia sine materia", thus confirming previous data available in medical literature. 相似文献
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D'Adamo P Welzl H Papadimitriou S Raffaele di Barletta M Tiveron C Tatangelo L Pozzi L Chapman PF Knevett SG Ramsay MF Valtorta F Leoni C Menegon A Wolfer DP Lipp HP Toniolo D 《Human molecular genetics》2002,11(21):2567-2580
Non-specific mental retardation (NSMR) is a common human disorder characterized by mental handicap as the only clinical symptom. Among the recently identified MR genes is GDI1, which encodes alpha Gdi, one of the proteins controlling the activity of the small GTPases of the Rab family in vesicle fusion and intracellular trafficking. We report the cognitive and behavioral characterization of mice carrying a deletion of Gdi1. The Gdi1-deficient mice are fertile and anatomically normal. They appear normal also in many tasks to assess spatial and episodic memory and emotional behavior. Gdi1-deficient mice are impaired in tasks requiring formation of short-term temporal associations, suggesting a defect in short-term memory. In addition, they show lowered aggression and altered social behavior. In mice, as in humans, lack of Gdi1 spares most central nervous system functions and preferentially impairs only a few forebrain functions required to form temporal associations. The general similarity to human mental retardation is striking, and suggests that the Gdi1 mutants may provide insights into the human defect and into the molecular mechanisms important for development of cognitive functions. 相似文献
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Compartmental Analysis of Breathing in the Supine and Prone Positions by Optoelectronic Plethysmography 总被引:2,自引:0,他引:2
Aliverti A Dellacà R Pelosi P Chiumello D Gatihnoni L Pedoti A 《Annals of biomedical engineering》2001,29(1):60-70
Optoelectronic plethysmography (OEP) has been shown to be a reliable method for the analysis of chest wall kinematics partitioned into pulmonary rib cage, abdominal rib cage, abdomen, and right and left side in the seated and erect positions. In this paper, we extended the applicability of this method to the supine and prone positions, typically adopted in critically ill patients. For this purpose we have first developed proper geometrical and mathematical models of the chest wall which are able to provide consistent and reliable estimations of total and compartmental volume variations in these positions suitable for clinical settings. Then we compared chest wall (CW) volume changes computed from OEP( V
CW) with lung volume changes measured with a water seal spirometer (SP) ( V
SP)in 10 normal subjects during quiet (QB) and deep (DB) breathing on rigid and soft supports. We found that on a rigid support the average differences between V
SP and V
CW were –4.2% ± 6.2%, –3.0% ± 6.1%, –1.7% ±7.0%, and –4.5% ± 9.8%, respectively, during supine/QB, supine/DB, prone/QB, and prone/DB. On the soft surface we obtained –0.1% ± 6.0%, –1.8% ± 7.8%, 18.0% ± 11.7%, and 10.2% ± 9.6%, respectively. On rigid support and QB, the abdominal compartment contributed most of the V
CW in the supine (63.1% ± 11.4%) and prone (53.5% ± 13.1%) positions. V
CW was equally distributed between right and left sides. In the prone position we found a different chest wall volume distribution between pulmonary and abdominal rib cage (22.1% ± 8.6% and 24.4% ± 6.8, respectively) compared with the supine position (23.3% ± 9.3% and 13.6% ± 3.0%). © 2001 Biomedical Engineering Society.
PAC01: 8763Lk, 8719Uv 相似文献