全文获取类型
收费全文 | 764篇 |
免费 | 39篇 |
国内免费 | 69篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 30篇 |
妇产科学 | 10篇 |
基础医学 | 90篇 |
口腔科学 | 12篇 |
临床医学 | 131篇 |
内科学 | 127篇 |
皮肤病学 | 23篇 |
神经病学 | 48篇 |
特种医学 | 140篇 |
外科学 | 61篇 |
综合类 | 26篇 |
预防医学 | 45篇 |
眼科学 | 7篇 |
药学 | 86篇 |
肿瘤学 | 32篇 |
出版年
2022年 | 3篇 |
2021年 | 6篇 |
2019年 | 3篇 |
2018年 | 8篇 |
2016年 | 11篇 |
2015年 | 11篇 |
2014年 | 12篇 |
2013年 | 21篇 |
2012年 | 18篇 |
2011年 | 21篇 |
2010年 | 39篇 |
2009年 | 30篇 |
2008年 | 34篇 |
2007年 | 76篇 |
2006年 | 28篇 |
2005年 | 22篇 |
2004年 | 24篇 |
2003年 | 22篇 |
2002年 | 15篇 |
2001年 | 12篇 |
2000年 | 22篇 |
1999年 | 21篇 |
1998年 | 29篇 |
1997年 | 39篇 |
1996年 | 25篇 |
1995年 | 22篇 |
1994年 | 22篇 |
1993年 | 23篇 |
1992年 | 12篇 |
1991年 | 12篇 |
1990年 | 17篇 |
1989年 | 21篇 |
1988年 | 26篇 |
1987年 | 20篇 |
1986年 | 16篇 |
1985年 | 20篇 |
1984年 | 8篇 |
1983年 | 8篇 |
1982年 | 11篇 |
1981年 | 7篇 |
1980年 | 10篇 |
1978年 | 7篇 |
1977年 | 9篇 |
1976年 | 10篇 |
1975年 | 8篇 |
1974年 | 3篇 |
1973年 | 3篇 |
1972年 | 6篇 |
1971年 | 4篇 |
1967年 | 4篇 |
排序方式: 共有872条查询结果,搜索用时 15 毫秒
41.
Etemad-Moghadam B Rhone D Steenbeke T Sun Y Manola J Gelman R Fanton JW Racz P Tenner-Racz K Axthelm MK Letvin NL Sodroski J 《Vaccine》2002,20(15):1934-1937
The efficacy of candidate AIDS vaccines to mediate protection against viral infection and pathogenesis is evaluated, at a preclinical stage, in animal models. One model that is favored because the infecting virus is closely related to HIV-1 and because of the rapidity of pathogenic outcomes is the infection of Old World monkeys by simian-human immunodeficiency virus (SHIV) chimerae. We investigated the basis for the depletion of CD4(+) T lymphocytes in a SHIV-macaque model. Molecularly cloned SHIVs, SHIV-89.6 and SHIV-KB9, differ in the ability to cause CD4(+) T-cell loss at a given level of virus replication in monkeys. The envelope glycoproteins of the pathogenic SHIV-KB9 mediate membrane-fusion in cultured T lymphocytes more efficiently than the envelope glycoproteins of the non-pathogenic SHIV-89.6. The minimal envelope glycoprotein region that specifies this increase in membrane-fusing capacity was sufficient to convert SHIV-89.6 into a virus that causes profound CD4(+) T-cell depletion in monkeys. Conversely, two single amino acid changes that decrease the membrane-fusing ability of the SHIV-KB9 envelope glycoproteins also attenuated the CD4(+) T-cell destruction that accompanied a given level of virus replication in SHIV-infected monkeys. Thus, the ability of the HIV-1 envelope glycoproteins to fuse membranes, which has been implicated in the induction of viral cytopathic effects in vitro, contributes to the capacity of the pathogenic SHIV to deplete CD4(+) T lymphocytes in vivo. 相似文献
42.
43.
44.
A case is presented of hyperkalaemia (13.6 mEq · L?1) occurring during cardiopulmonary bypass using warm blood cardioplegia (K+ 40–60 mEq · L?1). Treatment with epinephrine, calcium chloride, sodium bicarbonate, and furosemide reduced K+ to 6.5 mEq · L?1 within 30 min and myocardial performance was enhanced with amrinone and cardiac rhythm was controlled with A-V segmental pacing. It is believed that the hyperkalaemia resulted from a combination of the surgical procedure (mitral valve replacement) and the use of warm cardioplegia. The purpose of this report is to increase the awareness of the possibility of hyperkalaemia with warm cardioplegia and to describe a successful therapeutic regimen. 相似文献
45.
46.
47.
48.
49.
Hartmann G Marschner A Viveros PR Stahl-Hennig C Eisenblätter M Suh YS Endres S Tenner-Racz K Uberla K Racz P Steinman RM Ignatius R 《Vaccine》2005,23(25):3310-3317
Oligonucleotides containing CpG motifs (CpG ODN) are strong adjuvants for humoral immune responses but data on cellular immune responses in primates are scarce. Rhesus macaque blood contained similar numbers of plasmacytoid dendritic cells and B cells, the key sensors of CpG ODN, as human blood, and these cells were activated by CpG-A and CpG-B in vitro. In vivo, both ODNs induced equal plasma levels of interferon-inducible protein 10 and similarly enhanced antibody responses following i.m. injections of the ODNs, protein antigen, and aluminium hydroxide into rhesus macaques, whereas antigen-specific CD4(+) T cell responses were only slightly increased by CpG ODN. 相似文献
50.