大学生自我表露及其与主观幸福感的关系

目的:探讨大学生自我表露、主观幸福感现况及二者的关系.方法:根据浙江大学164名学生的问卷调查结果对Jourard SM自我表露问卷进行修订,用修订的自我表露问卷和幸福感指数量表对浙江大学的356名学生进行问卷调查.结果:不同信息类别的自我表露评分差异显著(F=50.24,P＜0.001),其中品味和兴趣(1.85±0.41)、学习(工作)(1.87±0.43)的自我表露评分均高于态度和看法(1.70±0.32)(t=7.870、8.256)、金钱(1.60±0.41,t=10.517、11.429)、个性(1.70±0.39)、身体(1.71±0.42)(P均＜0.001).目标人的主效应显著(有男/女朋友者、无男/女朋友者的自我表露问卷评分差异均有显著性,F=21.14、13.88,P＜0.001),信息类别和目标人的交互作用显著(F=76.15,P＜0.001).在金钱、身体、学习或工作方面大学生向父母表露多于向男、女性朋友(如金钱上:母亲1.81±0.59、父亲1.73±0.58,男朋友1.42±0.44,女朋友1.40±0.44;F=116.84,P=0.000).女性的表露程度高于男性(1.79±0.31/1.71±0.32,t=2.03,P=0.044).自我表露与主观幸福感呈正相关(r=0.16,P=0.003).分层回归显示自我表露对预测主观幸福感作出了新的贡献(△R2=0.021,P=0.006).结论:信息类别、目标人、被试性别会影响自我表露的程度,提升表露水平有助于改善主观幸福感.     

冷冻同种异体骨段移植修复股骨近段大块骨缺损

为观察大块冷冻同种异体骨移植后免疫功能的改变及预后,对13例恶性骨肿瘤瘤段切除后的骨缺损10.8～19.4cm(平均为14.6cm),分别采用冻冷异体松质骨段移植的髋关节加压融合术(6例)和异体股骨近段半关节移植成形术(7例)修复.10例分别于术前4天及术后14和28天检测其空腹外周血各项免疫学指标,以及术后3、6、9、12、24、48个月进行99mSPECT骨扫描(5例)和X-线片检查(12例),以观察宿主的免疫反应和异体骨愈合情况.结果:①外周血T淋巴细胞亚群(OKT3+,OKT4+,OKT8+)及血清补体(C3,C4)和循环免疫复合物(CiC)手术前后比较无显著性差异(P>0.05).②99mTe SPECT骨扫描显示:术后3～6个月移植的异体骨两端及髓腔内同位素浓集明显低于正常,而异体骨两端所对应的自体骨端同位素浓集明显高于正常,此现象于植入后9个月开始减弱,可达数年.X线片显示:异体骨愈合率为92.3%(12/13),2例移植的异体松质骨段于术后4～6年完全成活替代.以上可见:①冻冷异体骨段移植后宿主的全身免疫机能改变不明显,其反应是以局部炎症为主的细胞免疫过程;②异体骨可做为修复大块骨缺损的良好材料.     

Studies of β-lactamase production in ampicillin resistant Haemophilus influenzae

In 1972, HaelnOPhilus influenzae (HI) was firstlydiscovend being resistant against alnpicillin by producing5-lac~e, since then, studies on the rests~ mechamsms and the moleCular basis of 5-lactalnaSe Pwhctionhave been increasing year by yeax abroadll]. In 1978,Bryan et .l[2] first reported sabins of HI Producing 0-lactamaSe, which was mediated by plaaed, from then on,many stUdies foeused on 3-lactamase encoded by PlaSnddin HI and its relation with ampicillin resisboce. In ourco~, few st…     

妇科术后硬膜外腔注射吗啡镇痛效果观察

对妇科术后硬膜外腔注射吗啡镇痛效果进行观察分析探讨。对３ａ来我院使用术后硬膜外腔注射吗啡镇痛效果进行评定,对血压、脉博等情况观察进行总结分析。结果：硬膜外腔注射吗啡术后镇痛效果优８５．６％,良６．８％。副作用有血压下降达２７．８％、恶心呕吐１５．５％,头晕２３．０％。     

髁状突冷冻再植后颞下颌关节改变的实验研究

目的:为颞下颌关节肿瘤的治疗及关节重建提供一定的理论依据.材料和方法:对16只未成年日本大耳白兔的右侧髁状突施行了冷冻再植术.术后所有动物正常存活,第2、4、8、12周分别处死4只动物.采用常规组织学、扫描电镜及微血管显像等对髁状突和关节盘进行观察.结果:组织学检查发现随着血供逐渐恢复,失去活力的骨被新骨"爬行替代",而髁状突软骨的结构未完全恢复;扫描电镜检查证明了关节盘下腔面的表面结构基本正常,实验后期髁状突的表面较光滑,但无明显胶冻样物;微血管显像显示冷冻再植髁状突逐渐再血管化.16只动物中有3只的手术侧颞下颌关节发生轻度粘连. 结论这些结果证明:髁状突冷冻再植在颞下颌关节重建时有应用的可行性.     

中老年人脾肾虚证与血脂及抗氧化物关系的探讨

采用前瞻性设计方案,利用现代先进的有针对性的指标,应用单因素及多因素综合分析方法,对７７３例中老年人进行脾肾虚证实质的研究。结果发现：中老年人肾虚证与脂质代谢紊乱、机体经物质减少、过氧化脂质增密切相关。同时发现,脾虚证到肾虚证是一个逐渐发展的病理过程,且有层次性。认为肾虚证脂质代谢紊乱程度高于脾虚证,脾虚证与机体抗氧化物减少无密切关系。     

离子通道镶嵌点过程模型在K+通道研究中的应用

目的：用作者提出的离子通道镶嵌点过程模型拟合海马锥体细胞钾离子单通道记录数据分析１７β雌二醇的效应。方法：用协方差密度度量通道记忆,从３个方面做拟合优度检验。结果：该模型与观察资料拟合效果良好;１７β雌二醇能改变海马锥体细胞钾离子单通道的记忆;１７β雌二醇对关闭的影响比对开放的影响大,从而表现为对通道具有抑制作用：浓度为１０ｎｍｏｌ／Ｌ组的１７β雌二醇对通道记忆的影响比对浓度为０１ｎｍｏｌ／Ｌ组的大。结论：Ｍａｒｋｏｖ模型的常规分析只能得到１７β雌二醇对海马锥体细胞钾离子单通道具有抑制作用,而用本模型分析能得到更多通道的信息     

Short-term effects of high-dose 17beta-estradiol in postmenopausal PD patients: a crossover study.

OBJECTIVE: To examine the effect of 17beta-estradiol on the severity of the cardinal signs of PD in postmenopausal women. BACKGROUND: Although the impact of estrogens on the manifestations of PD has not been subjected to rigorous study, their use is generally thought to be associated with a detrimental antidopaminergic effect. METHODS: A double-blind, placebo-controlled, two-arm crossover study of high-dose transdermal 17beta-estradiol was conducted in eight postmenopausal women with mild to moderate PD, all but one of whom exhibited levodopa-induced dyskinesias. Patients were randomized initially to either hormonal treatment or placebo for 2 weeks, followed by a 2-week washout period, and then another 2-week crossover treatment period. Active treatment employed four skin patches each releasing 0.1 mg of estradiol daily, replaced every 2 to 3 days. RESULTS: After 10 days of treatment a significant reduction was observed in the antiparkinsonian threshold dose of IV levodopa. Mean duration and magnitude of the antiparkinsonian response to threshold or high doses of levodopa were unchanged, and dyskinesia scores were unaltered during 17beta-estradiol treatment compared with placebo. No worsening in "on" time or motor ratings with estrogen treatment was documented. CONCLUSIONS: 17beta-estradiol appears to display a slight prodopaminergic (or antiparkinsonian) effect without consistently altering dyskinesias. Standard postmenopausal replacement therapy with transdermal 17beta-estradiol is likely to be well tolerated by many female parkinsonian patients.