全文获取类型
收费全文 | 103456篇 |
免费 | 4360篇 |
国内免费 | 235篇 |
专业分类
耳鼻咽喉 | 1589篇 |
儿科学 | 3453篇 |
妇产科学 | 2645篇 |
基础医学 | 13695篇 |
口腔科学 | 3006篇 |
临床医学 | 6357篇 |
内科学 | 23480篇 |
皮肤病学 | 2984篇 |
神经病学 | 7973篇 |
特种医学 | 2415篇 |
外国民族医学 | 2篇 |
外科学 | 13431篇 |
综合类 | 521篇 |
一般理论 | 25篇 |
预防医学 | 11475篇 |
眼科学 | 2412篇 |
药学 | 7628篇 |
1篇 | |
中国医学 | 345篇 |
肿瘤学 | 4614篇 |
出版年
2023年 | 612篇 |
2022年 | 416篇 |
2021年 | 1732篇 |
2020年 | 924篇 |
2019年 | 1976篇 |
2018年 | 3425篇 |
2017年 | 2056篇 |
2016年 | 2025篇 |
2015年 | 2337篇 |
2014年 | 2510篇 |
2013年 | 4038篇 |
2012年 | 6637篇 |
2011年 | 6726篇 |
2010年 | 3482篇 |
2009年 | 2494篇 |
2008年 | 5512篇 |
2007年 | 5871篇 |
2006年 | 5734篇 |
2005年 | 5788篇 |
2004年 | 5335篇 |
2003年 | 4946篇 |
2002年 | 4685篇 |
2001年 | 3400篇 |
2000年 | 3560篇 |
1999年 | 2843篇 |
1998年 | 545篇 |
1997年 | 336篇 |
1996年 | 384篇 |
1992年 | 1321篇 |
1991年 | 1190篇 |
1990年 | 1125篇 |
1989年 | 1023篇 |
1988年 | 912篇 |
1987年 | 935篇 |
1986年 | 853篇 |
1985年 | 821篇 |
1984年 | 609篇 |
1983年 | 483篇 |
1979年 | 613篇 |
1978年 | 362篇 |
1976年 | 341篇 |
1975年 | 363篇 |
1974年 | 551篇 |
1973年 | 514篇 |
1972年 | 447篇 |
1971年 | 414篇 |
1970年 | 486篇 |
1969年 | 450篇 |
1968年 | 430篇 |
1967年 | 395篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
Carmen Guillén Ponce María Pilar Garrido López María José Molina Garrido Gema Muñoz Molina Alfredo Carrato 《Clinical & translational oncology》2007,9(1):53-55
Pituitary metastases of solid tumours are infrequent, specially as a first manifestation. When they happen, they are usually
due to breast or lung cancer and are asymptomatic or produce diabetes insipidus. It is very strange that they produce hormonal
deficiency.
We present a case report of a bronchogenic adenocarcinoma in a 65-year-old man which began with panhypopituitarism, diabetes
insipidus and visual alterations. Magnetic resonance imaging revealed a large sellar mass, with clivus infiltration and invading
the right cavernous sinus. The biopsy result was adenocarcinoma metastases from lung cancer. 相似文献
92.
Dónal P O'Mathúna 《BMC medical ethics》2006,7(1):2-12
Background
The justification for Nazi programs involving involuntary euthanasia, forced sterilisation, eugenics and human experimentation were strongly influenced by views about human dignity. The historical development of these views should be examined today because discussions of human worth and value are integral to medical ethics and bioethics. We should learn lessons from how human dignity came to be so distorted to avoid repetition of similar distortions. 相似文献93.
Successful pregnancy in primary glomerular disease 总被引:2,自引:0,他引:2
The course of 66 pregnancies was studied in 48 women with primary glomerular diseases. In all cases diagnoses were established by biopsy before pregnancy. They were: membranoproliferative glomerulonephritis in 16 patients, focal glomeruloesclerosis in 13, IgA nephropathy in 10, membranous nephropathy in seven and focal glomerulonephritis in two women. The clinical status of the nephropathy before conception was that 43 had only mild renal dysfunction, five had moderate renal insufficiency, serum creatinine (1.3 to 1.9 mg%), eight women had hypertension (150/100 mm Hg) and eight had nephrotic range proteinuria. Their clinical course was compared with a control group of 36 women with primary glomerular disease who did not become pregnant, and were matched for similar age, histological type, and status of nephropathy (renal function, blood pressure and proteinuria). After one year and at the end of the five year follow-up period, the incidence of hypertension, proteinuria, and renal failure was similar in the two groups. The fetal survival rate was 92%; 51 pregnancies ended in full-term delivery, with a mean birthweight of 3,242 +/- 320 g. There were seven pre-term deliveries (2,170 +/- 135 g), three small for gestational-age (2,340 +/- 135 g), two stillbirths and three spontaneous abortions. These patients had more pre-term deliveries (10.6%) and perinatal mortality (31%) than a normal population (5.5% and 9.6%, respectively). Blood pressure increased during pregnancy in 13 women; in 10 it was reversible, and in four it persisted after delivery. Ten gravidas developed increased proteinuria (reversible in six of them) and two others developed permanent impairment of renal function.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
94.
Juan M. Bellón MD Julia Buján MD Natalio G. Honduvilla MD Alvaro Hernando MD Jacinto Navlet MD 《Annals of vascular surgery》1995,9(3):266-273
Various methods of cryopreservation of human endothelial cells (EC) were studied to determine their viability and behavior when seeded onto vascular prostheses made of polytetrafluoroethylene (PTFE). Three different protocols were used: (1) cyropreservation of whole umbilical vein, (2) cyropreservation of freshly extracted umbilical EC in suspension, and (3) cryopreservation of EC derived from a first subculture. Fresh EC and EC from a first subculture were used as controls. The viability and growth of these cells in culture media were studied, and basal prostacyclin levels were determined. The cells were assessed morphologically after they were seeded onto PTFE discs. Our results showed that the cryopreservation method that maintained the greatest viability was that in which previously cultured EC were used. Basal prostacyclin levels were significantly different following cyropreservation. However, when these cells were seeded onto PTFE discs their behavior was similar to that of fresh EC.We thank W. L. Gore & Associates for supplying the prostheses used in this study.Supported by a grant from the Comision Interministerial de Cieucia y Tecnologia SAF 92/0875. 相似文献
95.
In order to clarify the physiological role in vivo of H2O2-detoxifying enzymes at low and high levels of O2 tension we studied catalase (CAT), glutathione peroxidases (GP), and in vivo peroxidation (TBA-RS) in the lung and heart of Rana perezi frogs chronically treated with hyperoxia, aminotriazole (AT) -a CAT inhibitor-, or both. Hyperoxia did not change CAT, GP or TBA-RS. Aminotriazole caused an almost complete depletion of CAT, a 30% decrease of GP and a 132% (lung) to 200% (heart) increase of TBA-RS. Changes similar to these were found in the group treated with AT in hyperoxia. No mortality or changes in total or organ weight occurred in the experimental groups. Main conclusions are: (1) The maximal hyperoxia tolerance showed by frogs among vertebrates does not need antioxidant enzyme induction from lung or heart and is probably related to the presence of high constitutive levels of GP in relation to metabolic rate. (2) Even in normoxia the tissues present significant amounts of H2O2, and CAT is needed to avoid oxidative damage. GP does not compensate its absence. The implications of these results in relation to oxygen toxicity in man is discussed. 相似文献
96.
97.
98.
Prospective study of antigenemia,plasma viremia and lymphocytic viremia in HIV-infected hemophiliacs
S. Melón Garcia M. de Oña Navarro C. Rodriguez Pinto M. Fernández Urgellés A. Martinez Gutierrez P. de la Iglesia F. J. Mendez García 《European journal of clinical microbiology & infectious diseases》1995,14(5):400-405
A total of 186 blood samples from 24 HIV-1 seropositive hemophiliac patients, monitored every four months for 29 months, were investigated for the presence of viral antigen in plasma. In addition, peripheral blood mononuclear cells (PBMC) were cultured for HIV-1, using normal PBMC as a target for replication. Antigenemia was detected in 51 % of the patients and from PBMC in 87.5 % of the patients. The incidence of HIV isolation in asymptomatic patients (42.8 %) was similar to that found in symptomatic patients (51.4 %). Patients with opportunistic infections had a higher incidence of lymphocytic viremia (p<0.05). Plasma viremia was closely associated (p<0.05) with low CD4+ counts and infection progression. The persistence of antigenemia was also a marker of a poor clinical course. In treated patients, plasma viremia was the marker that better correlated with the clinical course, and it did not appear during the first nine months of therapy. Zidovudine doses of >500 mg/day significantly lowered the appearance of antigenemia and lymphocytic viremia (p<0.05). 相似文献
99.
100.