血液透析与血液透析滤过急性肾衰竭患儿治疗前后血清P2微球蛋白下降率对比

目的探讨血液透析（HD）及血液透析滤过（HDF）治疗急性肾衰竭患儿前后血清陉微球蛋白（β2-MG）及下降率的影响。方法对各种原因导致的急性肾衰竭需行血液净化治疗38例患儿随机分成2组。HD组20例，HDF组18例。透析前后分别测血清β2-MG水平。结果HDF与HD前后血清陉．MG变化经统计学处理。HDF组治疗前后血清β2-MG水平差异有显著性意SL（P〈0．01）；HD组治疗前后血清β2-MG水平差异无显著性意义（P〉0．05）；HDF和HD组治疗后比较血清β2-MG水平差异、下降率差异均有显著性意义（P均〈0．01）。结论HDF清除血β2-MG明显优于HD。     

Outcomes of using Firebird rapamycin eluting stents in routine coronary intervention practice: one-year results from the pilot study of Firebird in China registry

Recent clinical trials with rapamycin-eluting stents have shown very low restenosis rates.1-4 However, the higher penetration of drug eluting stent (DES) in China is being limited by the high costs of these imported devices, especially when considering multiple stenting.     

医用回旋加速器原理及应用

本文简要介绍了医用回旋加速器的原理、系统组成和功能以及临床应用.     

重视中医理论建构研究,促进中医理论创新

纵观中医现代化的发展历程及其成果,似乎始终没有寻找到一条属于中医自己的现代化之路.究其原因,很重要的一条就是中医理论发展的严重滞后.中医理论要实现现代化,方法学的突破和思路的创新是关键,而中医理论建构方法的研究,对于中医理论以及中医学的发展和创新而言,具有十分重要的意义.     

清热抗感冲剂对小鼠IL-2水平影响的实验研究

目的:通过检测清热抗感冲剂对实验性免疫低下小鼠及正常小鼠血清IL-2水平的影响,探讨该冲剂对免疫功能的调节作用.方法:选取昆明种小鼠100只,雌雄各半,其中50只腹腔注射环磷酰胺3mg/0.2mL/只,每天给药1次,连续7天,造成免疫低下小鼠,然后随机分为模型组、中药对照组(银翘解毒片组)、西药对照组(γ-干扰素组)、小剂量组、大剂量组;其余50只随机分为正常空白对照组(即生理盐水组)、中药对照组、西药对照组、小剂量组、大剂量组.上述各组连续用药3天后,处死,采血,离心取血清,采用放免γ测量仪检测IL-2含量.结果:清热抗感冲剂能显著提高正常小鼠和注射环磷酰胺引起的免疫低下小鼠血清中IL-2生成水平(统计学处理P＜0.01).结论:清热抗感冲剂对小鼠的细胞免疫功能有明显的增强作用.     

Association between interleukin-10 genetic polymorphisms and risk of primary open angle glaucoma in a Chinese Han population: a case-control study

AIM: To investigate the association between interleukin-10 (IL-10) genetic polymorphisms and risk of POAG through a case-control study in a Han population of China. METHODS: A total of 210 patients with POAG and 420 normal subjects were recruited during the period from Dec. 2013 to Dec. 2016. The IL-10 -1082A>G (rs1800870), -819T>C (rs1800871) and -592C>A (rs1800872) polymorphisms were determined using iPlex GOLD SNP genotyping analysis (the SequenomMassARRAY® System, Sequenom, San Diego, USA). The association between IL-10 -1082A>G (rs1800870), -819T>C (rs1800871), and -592C>A (rs1800872) polymorphisms and risk of POAG was assessed by singlelogistic regression analysis. RESULTS: We observed that those carrying the CC genotype of rs1800871 was associated with an increased risk of POAG when compared with those harboring the TT genotype (OR=1.84, 95%CI=1.01-3.38). Those with AA genotype of rs1800872 had a 10.62 fold risk of POAG in comparison to the CC genotype (OR=10.62, 95%CI, 3.41-33.09). A completely linkage disequilibrium was found between IL-10 rs1800871-rs1800872 (D’=1.00, r2=0.16). The A-C-A (OR=2.60, 95%CI, 1.48-4.58) and G-T-A (OR=2.34, 95%CI, 1.42-3.86) haplotypes were associated with an increased risk of POAG, while the A-T-C haplotype showed a decreased risk of POAG (OR=0.63, 95%CI, 0.49-0.81). CONCLUSION: Our data suggest that IL-10 rs1800871 and rs1800872 can be predictive factors for the pathogenesis of POAG in the Chinese population.     

股骨颈骨折空心加压螺钉内固定手术前后的护理

空心加压螺钉内固定治疗股骨颈骨折具有切口小、创伤小、不需要特殊设备而又经济的优点,但其固定牵引度相对来说较低,所以做好手术前后的护理尤为重要.对此,笔者在长期的临床实践中积累了一定的护理经验,现介绍如下.