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排序方式: 共有1309条查询结果,搜索用时 15 毫秒
31.
John V. Asimakopoulos Maria K. Angelopoulou Maria-Panagiota Arapaki Alexandros Kanellopoulos Maria Dimou Xanthoula Giakoumis Eliana Konstantinou Marina Belia Chrysovalantou Chatzidimitriou Sotirios Sachanas Theodoros Iliakis Marie-Christine Kyrtsonis Marina P. Siakantaris Nora-Athina Viniou Eleni Variamis Flora N. Kontopidou Gerassimos A. Pangalis Panayiotis Panayiotidis Kostas Konstantopoulos Theodoros P. Vassilakopoulos 《British journal of haematology》2020,190(6):e335-e339
32.
Irene Fragiadaki Stavros Papadakis Georgia Sevastaki Katerina Sfyridaki Irene Mavroudi George N. Goulielmos Peggy Kanellou Anette Mörtberg Petter Höglund Katerina Gemenetzi Kostas Stamatopoulos Anastasia Chatzidimitriou Jan Palmblad Helen A. Papadaki 《American journal of hematology》2020,95(7):E163-E166
33.
Haris Georgiou Vasileios Patris Niki Lama Orestis Argiriou Kostas Soultanis 《International journal of surgery case reports》2014,5(10):703-705
INTRODUCTION
Right ventricular (RV) rupture with mediastinitis, is a very rare but extremely dangerous (even fatal) complication, following CABG surgery.PRESENTATION OF CASE
In this paper, we present the case of a post-trauma (after fall) RV rupture (without mediastinitis) in a patient who had undergone cardiac surgery several days ago. The cause of the rupture proved to be a broken bone piece from the lower sternal edge.DISCUSSION
RV rupture post-operatively caused by broken bone pieces or bone dislocation may occur through two mechanisms: either penetration of the RV, or through the “sandpaper effect”. In order to prevent the rupture, we should be able to recognize patients with aggravating factors (age, weight) and choose intra-operatively a suitable closure technique.CONCLUSION
We propose that the technique that could prevent such ruptures is the Robicsek technique. 相似文献34.
Prabhakar K. Jadhav Matthew A. Schiffler Kostas Gavardinas EuibongJ. Kim Donald P. Matthews Michael A. Staszak D. Scott Coffey Bruce W. Shaw Kenneth C. Cassidy Richard A. Brier Yuke Zhang Robert M. Christie William F. Matter Keyun Qing Jim D. Durbin Yong Wang GaryG. Deng 《ACS medicinal chemistry letters》2014,5(10):1138-1142
35.
Julie T-W. Wang Chiara Fabbro Enrica Venturelli Cécilia Ménard-Moyon Olivier Chaloin Tatiana Da Ros Laura Methven Antonio Nunes Jane K. Sosabowski Stephen J. Mather Martyn K. Robinson Julien Amadou Maurizio Prato Alberto Bianco Kostas Kostarelos Khuloud T. Al-Jamal 《Biomaterials》2014
Carbon nanotubes (CNTs) exhibit unique properties which have led to their applications in the biomedical field as novel delivery systems for diagnosis and therapy purposes. We have previously reported that the degree of functionalization of CNTs is a key factor determining their biological behaviour. The present study broadens the spectrum by investigating the impact of the diameter of CNTs using two series of multi-walled CNTs (MWNTs) with distinct differences in their diameters. Both MWNTs were doubly functionalized by 1,3-dipolar cycloaddition and amidation reactions, allowing the appended functional groups to be further conjugated with radionuclide chelating moieties and antibodies or antibody fragments. All constructs possessed comparable degree of functionalization and were characterized by thermogravimetric analysis, transmission electron microscopy, gel electrophoresis and surface plasmon resonance. The MWNT conjugates were radio-labelled with indium-111, which thereby enabled in vivo single photon emission computed tomography/computed tomography (SPECT/CT) imaging and organ biodistribution study using γ-scintigraphy. The narrow MWNTs (average diameter: 9.2 nm) demonstrated enhanced tissue affinity including non-reticular endothelial tissues compared to the wider MWNTs (average diameter: 39.5 nm). The results indicate that the higher aspect ratio of narrow MWNTs may be beneficial for their future biological applications due to higher tissue accumulation. 相似文献
36.
37.
Redefying the therapeutic strategies against cardiorenal morbidity and mortality: Patient phenotypes
Chronic kidney disease(CKD) patients face an unacceptably high morbidity and mortality, mainly from cardiovascular diseases. Diabetes mellitus, arterial hypertension and dyslipidemia are highly prevalent in CKD patients. Established therapeutic protocols for the treatment of diabetes mellitus, arterial hypertension,and dyslipidemia are not as effective in CKD patients as in the general population. The role of non-traditional risk factors(RF) has gained interest in the last decades. These entail ... 相似文献
38.
Kostas Hadjidimitrakis Masoud Ghodrati Rossella Breveglieri Marcello G. P. Rosa Patrizia Fattori 《The Journal of comparative neurology》2020,528(17):3108-3122
Goal-directed movements involve a series of neural computations that compare the sensory representations of goal location and effector position, and transform these into motor commands. Neurons in posterior parietal cortex (PPC) control several effectors (e.g., eye, hand, foot) and encode goal location in a variety of spatial coordinate systems, including those anchored to gaze direction, and to the positions of the head, shoulder, or hand. However, there is little evidence on whether reference frames depend also on the effector and/or type of motor response. We addressed this issue in macaque PPC area V6A, where previous reports using a fixate-to-reach in depth task, from different starting arm positions, indicated that most units use mixed body/hand-centered coordinates. Here, we applied singular value decomposition and gradient analyses to characterize the reference frames in V6A while the animals, instead of arm reaching, performed a nonspatial motor response (hand lift). We found that most neurons used mixed body/hand coordinates, instead of “pure” body-, or hand-centered coordinates. During the task progress the effect of hand position on activity became stronger compared to target location. Activity consistent with body-centered coding was present only in a subset of neurons active early in the task. Applying the same analyses to a population of V6A neurons recorded during the fixate-to-reach task yielded similar results. These findings suggest that V6A neurons use consistent reference frames between spatial and nonspatial motor responses, a functional property that may allow the integration of spatial awareness and movement control. 相似文献
39.
Despoina Koumpagioti Barbara Boutopoulou Dafni Moriki Kostas N. Priftis Konstantinos Douros 《Nutrients》2022,14(8)
Dietary pattern may potentially impact on the pathogenesis of asthma and allergies. The Mediterranean Diet (MD) has significant health benefits due to its antioxidant and anti-inflammatory properties. The aim of this systematic review was to investigate the effectiveness of adherence to the MD against asthma and allergies in childhood. Hence, a systematic literature search was conducted on PubMed, ESBCO (Cinahl), Scopus, and the Cochrane Library databases up to 26 January 2022. The total number of articles obtained, after the initial search on the databases was conducted, was 301. Twelve studies were included, after the removal of duplicates and screening for eligibility. Our findings indicated a protective role of the MD against childhood asthma, but they also imply that the MD probably does not affect the development of allergies. Nevertheless, the heterogeneity and limitations of the studies highlight the need for randomized controlled trials that will focus on the pediatric population and hopefully provide more robust evidence. 相似文献
40.
Translocation mechanisms of chemically functionalised carbon nanotubes across plasma membranes 总被引:1,自引:0,他引:1
Lacerda L Russier J Pastorin G Herrero MA Venturelli E Dumortier H Al-Jamal KT Prato M Kostarelos K Bianco A 《Biomaterials》2012,33(11):3334-3343
Understanding the mechanisms responsible for carbon nanotube (CNT) internalisation into live cells is considered critical both from a fundamental point of view and for further engineering of CNT-based delivery systems to intracellular targets. While several studies are focused on the development of such CNT-based delivery systems, attempts to systematically elucidate the cellular uptake mechanisms of CNTs are still rather limited. The aim of the present study is to evaluate the cellular internalisation of chemically functionalised multi-walled carbon nanotubes (f-MWCNTs) in the presence of different well-known cellular uptake inhibitors. Our data reveal how f-MWCNTs are able to translocate across cell membranes of both phagocytic and non-phagocytic cell lines. We have evidenced that at least 30-50% of f-MWCNTs are taken up by cells through an energy-independent mechanism. This characteristic makes nanotubes loaded with therapeutic or diagnostic cargos extremely interesting as the release of active molecules directly into the cytoplasm increase their biological activity and therapeutic efficacy. 相似文献