全文获取类型
收费全文 | 7038篇 |
免费 | 320篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 180篇 |
儿科学 | 156篇 |
妇产科学 | 262篇 |
基础医学 | 774篇 |
口腔科学 | 70篇 |
临床医学 | 507篇 |
内科学 | 2155篇 |
皮肤病学 | 53篇 |
神经病学 | 586篇 |
特种医学 | 291篇 |
外科学 | 827篇 |
综合类 | 46篇 |
一般理论 | 1篇 |
预防医学 | 348篇 |
眼科学 | 122篇 |
药学 | 568篇 |
中国医学 | 3篇 |
肿瘤学 | 446篇 |
出版年
2024年 | 5篇 |
2023年 | 47篇 |
2022年 | 252篇 |
2021年 | 439篇 |
2020年 | 120篇 |
2019年 | 203篇 |
2018年 | 246篇 |
2017年 | 164篇 |
2016年 | 169篇 |
2015年 | 212篇 |
2014年 | 285篇 |
2013年 | 354篇 |
2012年 | 596篇 |
2011年 | 591篇 |
2010年 | 317篇 |
2009年 | 214篇 |
2008年 | 374篇 |
2007年 | 425篇 |
2006年 | 470篇 |
2005年 | 409篇 |
2004年 | 427篇 |
2003年 | 370篇 |
2002年 | 313篇 |
2001年 | 42篇 |
2000年 | 45篇 |
1999年 | 60篇 |
1998年 | 30篇 |
1997年 | 23篇 |
1996年 | 18篇 |
1995年 | 17篇 |
1994年 | 12篇 |
1993年 | 16篇 |
1992年 | 14篇 |
1991年 | 14篇 |
1990年 | 7篇 |
1989年 | 12篇 |
1988年 | 7篇 |
1987年 | 4篇 |
1986年 | 12篇 |
1985年 | 9篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1981年 | 5篇 |
1980年 | 3篇 |
1979年 | 6篇 |
1974年 | 3篇 |
1973年 | 6篇 |
1972年 | 3篇 |
1967年 | 2篇 |
1966年 | 4篇 |
排序方式: 共有7395条查询结果,搜索用时 15 毫秒
81.
82.
83.
84.
Piotr J. Burliński Anna M. Burlińska Sławomir Gonkowski Jarosław Całka 《Journal of molecular neuroscience : MN》2013,49(1):62-67
Both resiniferatoxin (RTX) and tetrodotoxin (TTX) have been reported to be effective in several urinary bladder dysfunction clinical trials. The aim of this study was to establish the effect of intravesical administration of RTX and TTX on neuropeptides Y (NPY) and tyrosine hydroxylase (TH) relationship in the paracervical ganglion (PCG) neurons supplying the urinary bladder in the pig. TH is an enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to dihydroxyphenylalanine (DOPA) and is used as a marker of catecholaminergic neurons. NPY augments the vasoconstrictor effects of noradrenergic neurons, and is involved in pathophysiological processes as a neuromodulator. To identify the PCG neurons supplying urinary bladder Fast Blue (FB) was injected into the bladder wall prior to intravesical RTX or TTX administration. Consequent application of immunocytochemical methods revealed that in control group 64.08 % of FB-positive PCG neurons contain NPY and 4.25 % TH. Intravesical infusion of RTX resulted upregulation of the NPY-IR neurons to 82.97 % and TH-IR to 43.78 %. Also administration of TTX induced further increase number of TH-IR neurons to 77.49 % but induced decrease number of NPY-IR neurons to 57.45 %. Both neurotoxins affect chemical coding of the PCG neural somata supplying urinary bladder, but the effects of their action are different. This results shed light on possible involvement of RTX and TTX on curing tissue, and potentially could help us to broaden our neurourological armamentarium. 相似文献
85.
Antonio Ysunza Kenneth ShaheenDavid J. Aughton Mark A. MicaleRichard Merson Kris Rutkowski 《International journal of pediatric otorhinolaryngology》2013
Jacobsen syndrome is an uncommon but well-known contiguous gene syndrome caused by partial deletion involving the long arm of chromosome 11. Most common features include: psychomotor impairment, facial dysmorphism, and thrombocytopenia. Cleft palate has been rarely reported. 相似文献
86.
ABSTRACTIntroduction: Mantle cell lymphoma (MCL) is a disease with an indolent histology, but mostly aggressive clinical course. While treatment can yield more promising results in younger patients, the disease is most diagnosed at a median age of approximately 70 years, and treatment in this group still presents a major challenge for oncohematologists. Unfortunately, due to comorbidities and poorer general status, the implementation of intensive treatment approaches with the cytarabine-based regimens and autologous stem cell transplantation is generally not possible, and the disease remains incurable, especially in elderly patients.Areas covered: In this paper, the authors discuss the therapeutic options available for older patients with MCL in the first line and relapsed/refractory settings, indicating new therapeutic options, which may achieve longer remissions and overall survival.Expert opinion: Although great progress has been made in the treatment of MCL in recent years, there remains a need for new treatment lines which can allow improved patient outcomes. Novel agents targeting altered the signal transduction pathways in MCL cells may offer more promise than traditional chemotherapy or immunochemotherapy and are currently being tested in clinical trials. 相似文献
87.
Aleksander Ku Mikoaj Radziszewski Aleksandra Glina Konrad Szymaski Beata Jurecka‐Lubieniecka Edyta Pawlak‐Adamska Dorota Kula Natalia Wawrusiewicz‐Kurylonek Joanna Ku Piotr Mikiewicz Rafa Poski Marek Bolanowski Jacek Daroszewski Barbara Jarzb Artur Bossowski Tomasz Bednarczuk 《Clinical endocrinology》2019,90(2):320-327
88.
89.
Wróbel Andrzej Doboszewska Urszula Rechberger Ewa Rojek Karol Serefko Anna Poleszak Ewa Skalicka-Woźniak Krystyna Dudka Jarosław Wlaź Piotr 《Naunyn-Schmiedeberg's archives of pharmacology》2017,390(6):613-619
Naunyn-Schmiedeberg's Archives of Pharmacology - Hemorrhagic cystitis often develops in patients treated with cyclophosphamide (CYP). Studies have indicated that Rho kinase (ROCK) inhibitors... 相似文献
90.