Mucous membrane manifestations in HIV infection

We report the occurrence of mucous membrane manifestations in six patients with HIV-infections: Kaposi sarcomas of the hard palate, of the gingiva, of the larynx and of the glans penis, unusual spreading of condylomata acuminata, bowenoid papulosis, thrush and hairy leukoplakia.     

Anstieg der Syphilis in der Alpen-, Donau-, Moldauregion

Ohne Zusammenfassung     

Über die Histotopie von NADH- und NADPH-Tetrazoliumreduktase in menschlicher Haut

Ohne ZusammenfassungMit 10 Textabbildungen     

Effects of antimicrobial therapy on sperm-mucus interaction

Sperm-mucus interaction under in-vitro or in-vivo conditionsmight be affected by microorganisms colonizing the reproductivetract. In order to study the influence of antimicrobial therapy,an extensive microbial screening was performed including Chlamydiatrachomatis, Mycoplasma hominis, Ureaplasma urealyticum, Neisseriagonorrhoeae, a broad spectrum of potentially pathogenic aerobicand anaerobic bacteria, Trichomonas vaginalis, herpes simplexvirus and yeasts. One-hundred-and-six couples with a mean durationof infertility of 5.5 years (range 1–12 years) and withisolation of potentially pathogenic microorganisms in semensamples and/or cervical swabs were submitted to a prospectivepilot study. None of the patients displayed signs or symptomsof infection in the lower genital tract. Before and after specifictherapy, based on antimicrobial susceptibility testing, spermanalyses and in-vitro sperm penetration meter tests (SPMT) (Kremer)were performed. SPMT was evaluated with cervical mucus of patients'wives, collected after a standardized oral treatment with oestrogensand, additionally, in a crossed manner with cervical mucus andspermatozoa of fertile donors. The success of antimicrobialtherapy was controlled by repeating the same mkrobial screeningand was 96%. However, there was a marked change in the mkrobialpattern. A comparison of the results of sperm analyses beforeand after treatment revealed neither significant differencesfor sperm volume, sperm count, propulsive motility, morphology,vitality, pH, fructose concentration or number of round cells,nor was there a significant influence on the cervical indexand the number of leukocytes in cervical mucus. In the SPMTpenetration distance, sperm density, quality and duration ofmotility were not significantly influenced by antimicrobialmedication, but were improved in the group of patients withvery poor SPMT results before treatment. The overall pregnancyrate was low (17% after 6 months, 21% after 12 months). Theresults suggest that microbial colonization is of minor importancefor sperm-mucus interaction and that the benefits of antimicrobialtherapy in asymptomatic couples are limited.     

Die praktische Bedeutung der Histochemie

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Sensitivity of Neisseria gonorrhoeae to spectinomycin and thiamphenicol.

Between 1966 and 1978 the sensitivities of strains of Neisseria gonorrhoeae (70-80 strains in each year) to penicillin, thiamphenicol, and spectinomycin were tested. For penicillin the proportion of less sensitive strains increased from 21% in 1976 to 41% in 1978 and for thiamphenicol from 10% to 18% over the same period. All the strains proved to be sensitive to spectinomycin. A significant correlation in the degree of sensitivity was observed between penicillin and thiamphenicol but not between penicillin and spectinomycin.