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101.
Juliane Menzel Klaus Abraham Gabriele I. Stangl Per Magne Ueland Rima Obeid Matthias B. Schulze Isabelle Herter-Aeberli Tanja Schwerdtle Cornelia Weikert 《Nutrients》2021,13(2)
Scientific evidence suggests that a vegan diet might be associated with impaired bone health. Therefore, a cross-sectional study (n = 36 vegans, n = 36 omnivores) was used to investigate the associations of veganism with calcaneal quantitative ultrasound (QUS) measurements, along with the investigation of differences in the concentrations of nutrition- and bone-related biomarkers between vegans and omnivores. This study revealed lower levels in the QUS parameters in vegans compared to omnivores, e.g., broadband ultrasound attenuation (vegans: 111.8 ± 10.7 dB/MHz, omnivores: 118.0 ± 10.8 dB/MHz, p = 0.02). Vegans had lower levels of vitamin A, B2, lysine, zinc, selenoprotein P, n-3 fatty acids, urinary iodine, and calcium levels, while the concentrations of vitamin K1, folate, and glutamine were higher in vegans compared to omnivores. Applying a reduced rank regression, 12 out of the 28 biomarkers were identified to contribute most to bone health, i.e., lysine, urinary iodine, thyroid-stimulating hormone, selenoprotein P, vitamin A, leucine, α-klotho, n-3 fatty acids, urinary calcium/magnesium, vitamin B6, and FGF23. All QUS parameters increased across the tertiles of the pattern score. The study provides evidence of lower bone health in vegans compared to omnivores, additionally revealing a combination of nutrition-related biomarkers, which may contribute to bone health. Further studies are needed to confirm these findings. 相似文献
102.
Ebbe Eldrup Simone Theilade Mette Lorenzen Christine H Andreassen Katrine H Poulsen John E Nielsen Ditte Hansen Daniel El Fassi Jais O Berg Per Bagi Anne Jørgensen Martin Blomberg Jensen 《Journal of bone and mineral research》2021,36(2):322-333
Intramuscular injections of paraffin oil can cause foreign body granuloma formation and hypercalcemia. Macrophages with the ability to produce high levels of 1,25(OH)2D3 may induce the mineral disturbance, but no major series of patients have been published to date. Here, medical history, physical evaluation, biochemical, and urinary analysis for calcium homeostasis were obtained from 88 males, who 6 years previously had injected paraffin or synthol oil into skeletal muscle. Moreover, granuloma tissue from three men was cultured for 48 hours ex vivo to determine 1,25(OH)2D3 production supported by qPCR and immunohistochemistry of vitamin D metabolism and immune cell populations after treatment with 14 different drugs. The 88 men were stratified into men with hypercalcemia (34%), whereas normocalcemic men were separated into men with either normal (42%) or suppressed parathyroid hormone (PTH) (24%). All men had high calcium excretion, and nephrolithiasis was found in 48% of hypercalcemic men, 22% of normocalcemic men with normal PTH, and 47% of normocalcemic men with suppressed PTH. Risk factors for developing hypercalcemia were oil volume injected, injection of heated oil, high serum interleukin-2 receptor levels, and high urine calcium. High 1,25(OH)2D3/25OHD ratio, calcium excretion, and low PTH was associated with nephrolithiasis. The vitamin D activating enzyme CYP27B1 was markedly expressed in granuloma tissue, and 1,25(OH)2D3 was released in concentrations corresponding to 40% to 50% of the production by human kidney specimens. Dexamethasone, ketoconazole, and ciclosporin significantly suppressed granulomatous production of 1,25(OH)2D3. In conclusion, this study shows that injection of large oil volumes alters calcium homeostasis and increases the risk of nephrolithiasis. Hypercalciuria is an early sign of disease, and high granulomatous 1,25(OH)2D3 production is part of the cause. Prospective clinical trials are needed to determine if ciclosporin, ketoconazole, or other drugs can be used as prednisolone-sparing treatment. © 2020 American Society for Bone and Mineral Research (ASBMR). 相似文献
103.
Vikram Sharma Kevin Chen Shehab A.R. Alansari Beni Verma Edward G. Soltesz Douglas R. Johnston Michael Zhen-Yu Tong Eric E. Roselli Per Wierup Gösta B. Pettersson A. Marc Gillinov Stephen G. Ellis Conrad Simpfendorfer Eugene H. Blackstone Samir Kapadia Lars G. Svensson Faisal G. Bakaeen 《The Annals of thoracic surgery》2021,111(5):1494-1501
104.
John M. Søfteland Gustav Friman Bengt von Zur-Mühlen Bo-Göran Ericzon Carin Wallquist Kristjan Karason Vanda Friman Jan Ekelund Marie Felldin Jesper Magnusson Ida Haugen Löfman Andreas Schult Emily de Coursey Susannah Leach Hanna Jacobsson Jan-Åke Liljeqvist Ali R. Biglarnia Per Lindnér Mihai Oltean 《American journal of transplantation》2021,21(8):2762-2773
Solid organ transplant (SOT) recipients run a high risk for adverse outcomes from COVID-19, with reported mortality around 19%. We retrospectively reviewed all known Swedish SOT recipients with RT-PCR confirmed COVID-19 between March 1 and November 20, 2020 and analyzed patient characteristics, management, and outcome. We identified 230 patients with a median age of 54.0 years (13.2), who were predominantly male (64%). Most patients were hospitalized (64%), but 36% remained outpatients. Age >50 and male sex were among predictors of transition from outpatient to inpatient status. National early warning Score 2 (NEWS2) at presentation was higher in non-survivors. Thirty-day all-cause mortality was 9.6% (15.0% for inpatients), increased with age and BMI, and was higher in men. Renal function decreased during COVID-19 but recovered in most patients. SARS-CoV-2 antibodies were identified in 78% of patients at 1–2 months post-infection. Nucleocapsid-specific antibodies decreased to 38% after 6–7 months, while spike-specific antibody responses were more durable. Seroprevalence in 559 asymptomatic patients was 1.4%. Many patients can be managed on an outpatient basis aided by risk stratification with age, sex, and NEWS2 score. Factors associated with adverse outcomes include older age, male sex, greater BMI, and a higher NEWS2 score. 相似文献
105.
Per Kragh Andersen Maja Pohar Perme Hans C. van Houwelingen Richard J. Cook Pierre Joly Torben Martinussen Jeremy M. G. Taylor Michal Abrahamowicz Terry M. Therneau 《Statistics in medicine》2021,40(1):185-211
This paper provides guidance for researchers with some mathematical background on the conduct of time‐to‐event analysis in observational studies based on intensity (hazard) models. Discussions of basic concepts like time axis, event definition and censoring are given. Hazard models are introduced, with special emphasis on the Cox proportional hazards regression model. We provide check lists that may be useful both when fitting the model and assessing its goodness of fit and when interpreting the results. Special attention is paid to how to avoid problems with immortal time bias by introducing time‐dependent covariates. We discuss prediction based on hazard models and difficulties when attempting to draw proper causal conclusions from such models. Finally, we present a series of examples where the methods and check lists are exemplified. Computational details and implementation using the freely available R software are documented in Supplementary Material. The paper was prepared as part of the STRATOS initiative. 相似文献
106.
Niels Ødum Niels Morling Johannes Friis Carsten Heilmann Jens J. Hyldig-Nielsen Bodil K. Jakobsen Freddy Karup Pedersen Per Platz Lars P. Ryder Arne Svejgaard 《Tissue antigens》1986,28(4):245-250
Thirty-six unrelated Danish patients with pauciarticular Juvenile Chronic Arthritis (PJCA) and 120 controls were typed for HLA-DPw1-w6 and the local specificity CDPHEI with bulk-expanded Primed Lymphocyte Typing (PLT) cells. The frequency of HLA-DPw2 was 52.8% in PJCA patients and 16.7% in controls (relative risk, RR = 4.5; P less than 0.001). The antigens HLA-Dw5 and/or Dw8 were present in 50% of the patients and in 21.3% of the controls (RR = 4.2; p less than 10(-3)). DPw2 was not associated (in linkage disequilibrium) with Dw5/w8 in patients or in controls, and the DP and D associations with PJCA were independent of each other. However, the combined presence of DPw2 and Dw5 and/or Dw8 gave a significantly higher risk of PJCA than each antigen alone indicating interaction of DP and DR gene products. PJCA is the first disease definitely found to be associated with a DP antigen. 相似文献
107.
Quy N. Diep Thomas Bøhmer Jan I. Holme Ansgar Torvik Olav T. Storrøsten Christian W. Loennecken Per Monstad Egil Jellum 《Pharmacy World & Science》1993,15(5):225-229
Long-term treatment with pivampicillin and pivmecillinam for 6–24 months in five adults and one child reduced the total serum carnitine concentration to 3.7–14 mol/l (reference value: 25–66 mol/l). Muscle carnitine was reduced to 0.3–0.7mol/g wet weight (reference value: 3–5mol/g) in two cases. All patients had muscle symptoms with weakness, asthenia and pains. One showed signs of carnitine depletion in the liver with increased secretion of dicarboxylic acids (C6, C8, C10) in urine and limited ketone body formation during prolonged fasting. Serum carnitine increased slowly after cessation of therapy and reached normal concentrations after 6–12 months. All symptoms caused by carnitine depletion disappeared. This was achieved on a normal diet without carnitine supplementation. 相似文献
108.
Per Jensen M.D. Søren Buus Jensen M.D. Per Soelberg Sørensen M.D. Birgitte D. Bjerre M.D. Dominick A. Rizzi M.D. Anne Stub Sørensen M.D. Rene Klysner M.D. Kim Brinch M.D. Bo Jespersen M.D. Henrik Nielsen M.D. 《Archives of sexual behavior》1990,19(1):1-14
Sexual dysfunction is a well-known complication of chronic somatic illness. Eighty-six consecutive epileptic outpatients, 38 men and 48 women, without accompanying disorders, were studied. The frequency and symptoms of sexual dysfunction were compared with results from previous studies using identical sexological methodology. The previous studies were of diabetic patients and healthy controls. Eight percent of the epileptic men reported a sexual dysfunction compared to 44% of the diabetics and 13% of the controls. Epileptic women, diabetic women, and controls showed no significant differences in sexual dysfunction (29%, 28%, and 25%, respectively). In both sexes, the sexual function measured by frequencies of coitus and masturbation was normal. Most patients had good control of epileptic attacks on a treatment of monotherapy. Hormonal status was generally within normal limits in both men and women; only a few minor differences were found and they showed no correlation with sexual dysfunction. Psychologically and socially the patients did not differ appreciably from normals, and they exhibited a high degree of disease acceptance. This study, using a biopsychosocial approach in understanding sexual dysfunctions, is in contrast with previous, mainly uncontrolled, studies of epileptic patients that reported high frequencies of hyposexuality in males. We conclude that epilepsy does not necessarily increase the risk of sexual dysfunction in male or female. 相似文献
109.
The purpose of this study is to present the authors' long-term experience with total corporal contouring with megaliposuction.
The evolution of body reshaping in one operative setting including simultaneous head and neck contouring, upper and lower
extremity recontouring, and creation of an aesthetic trunk and abdominal form is discussed. Patient evaluation, operative
techniques, postoperative management, and long-term results are emphasized. From February 1994 to February 1997, 120 consecutive
patients underwent total corporal contouring with tumescent (Hunstad formula)-technique, classic liposuction. There were 10
males and 110 females. The average age of all patients was 28 years. Preoperative evaluation emphasized corporal shape and
proportions. No other open procedures were performed simultaneously in these patients. The authors' postoperative regimen
is discussed. The average amount of aspirated material in these series was 14,000 ml (range, 8000–20,000 ml). No blood transfusions
were required. Complications included only hypopigmentation (N= 2) and postoperative seromas requiring aspiration (N= 12). Follow-up examination took place at 3 months to 3 years, with an average of 14 months. All patients underwent a metamorphosis
from an amorphic shape to one that follows the normal body contours and profiles. The goals of megaliposuction are no longer
just to reduce body fat and body mass. Individually planned surgery for these patients should be based upon obtaining normal
symmetrical body proportions. Total corporal contouring and reshaping can now be safely performed, offering hope and predictable
outcomes to this patient population. Patient evaluation, operative technique, postoperative care, and long-term results are
presented. 相似文献
110.
A Wagstaff E van Doorslaer H van der Burg S Calonge T Christiansen G Citoni U G Gerdtham M Gerfin L Gross U H?kinnen P Johnson J John J Klavus C Lachaud J Lauritsen R Leu B Nolan E Perán J Pereira C Propper F Puffer L Rochaix M Rodríguez M Schellhorn O Winkelhake 《Journal of health economics》1999,18(3):263-290
This paper presents further international comparisons of progressivity of health care financing systems. The paper builds on the work of Wagstaff et al. [Wagstaff, A., van Doorslaer E., et al., 1992. Equity in the finance of health care: some international comparisons, Journal of Health Economics 11, pp. 361-387] but extends it in a number of directions: we modify the methodology used there and achieve a higher degree of cross-country comparability in variable definitions; we update and extend the cross-section of countries; and we present evidence on trends in financing mixes and progressivity. 相似文献