全文获取类型
收费全文 | 1024920篇 |
免费 | 72057篇 |
国内免费 | 2840篇 |
专业分类
耳鼻咽喉 | 13734篇 |
儿科学 | 32358篇 |
妇产科学 | 28561篇 |
基础医学 | 144156篇 |
口腔科学 | 26947篇 |
临床医学 | 87366篇 |
内科学 | 210025篇 |
皮肤病学 | 20422篇 |
神经病学 | 83682篇 |
特种医学 | 40428篇 |
外国民族医学 | 338篇 |
外科学 | 160172篇 |
综合类 | 20675篇 |
现状与发展 | 1篇 |
一般理论 | 406篇 |
预防医学 | 75177篇 |
眼科学 | 23299篇 |
药学 | 72696篇 |
1篇 | |
中国医学 | 2077篇 |
肿瘤学 | 57296篇 |
出版年
2021年 | 8225篇 |
2019年 | 8807篇 |
2018年 | 11912篇 |
2017年 | 9241篇 |
2016年 | 10089篇 |
2015年 | 11547篇 |
2014年 | 16417篇 |
2013年 | 24926篇 |
2012年 | 34220篇 |
2011年 | 36577篇 |
2010年 | 21788篇 |
2009年 | 20628篇 |
2008年 | 34533篇 |
2007年 | 36576篇 |
2006年 | 36315篇 |
2005年 | 35902篇 |
2004年 | 34341篇 |
2003年 | 32910篇 |
2002年 | 32187篇 |
2001年 | 42568篇 |
2000年 | 43472篇 |
1999年 | 37512篇 |
1998年 | 11530篇 |
1997年 | 10476篇 |
1996年 | 10112篇 |
1995年 | 9454篇 |
1994年 | 8972篇 |
1993年 | 8427篇 |
1992年 | 28923篇 |
1991年 | 27611篇 |
1990年 | 26974篇 |
1989年 | 25889篇 |
1988年 | 24077篇 |
1987年 | 23657篇 |
1986年 | 22685篇 |
1985年 | 21634篇 |
1984年 | 16392篇 |
1983年 | 14016篇 |
1982年 | 8785篇 |
1979年 | 14961篇 |
1978年 | 10556篇 |
1977年 | 8969篇 |
1976年 | 8436篇 |
1975年 | 9223篇 |
1974年 | 10968篇 |
1973年 | 10442篇 |
1972年 | 9861篇 |
1971年 | 9082篇 |
1970年 | 8726篇 |
1969年 | 8151篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
101.
Tien‐Yao Tsai Iat‐Lon Leong Ka‐Shun Cheng Lian‐Ru Shiao Tzu‐Hui Su Kar‐Lok Wong Paul Chan Yuk‐Man Leung 《Fundamental & clinical pharmacology》2019,33(1):52-62
A pathological feature in atherosclerosis is the dysfunction and death of vascular endothelial cells (EC). Oxidized low‐density lipoprotein (LDL), known to accumulate in the atherosclerotic arterial walls, impairs endothelium‐dependent relaxation and causes EC apoptosis. A major bioactive ingredient of the oxidized LDL is lysophosphatidylcholine (LPC), which at higher concentrations causes apoptosis and necrosis in various EC. There is hitherto no report on LPC‐induced cytotoxicity in brain EC. In this work, we found that LPC caused cytosolic Ca2+ overload, mitochondrial membrane potential decrease, p38 activation, caspase 3 activation and eventually apoptotic death in mouse cerebral bEND.3 EC. In contrast to reported reactive oxygen species (ROS) generation by LPC in other EC, LPC did not trigger ROS formation in bEND.3 cells. Pharmacological inhibition of p38 alleviated LPC‐inflicted cell death. We examined whether heparin could be cytoprotective: although it could not suppress LPC‐triggered Ca2+ signal, p38 activation and mitochondrial membrane potential drop, it did suppress LPC‐induced caspase 3 activation and alleviate LPC‐inflicted cytotoxicity. Our data suggest LPC apoptotic death mechanisms in bEND.3 might involve mitochondrial membrane potential decrease and p38 activation. Heparin is protective against LPC cytotoxicity and might intervene steps between mitochondrial membrane potential drop/p38 activation and caspase 3 activation. 相似文献
102.
103.
Anastasiia Panfilova Sarah E. Shelton Cristina Caresio Ruud J.G. van Sloun Filippo Molinari Hessel Wijkstra Paul A. Dayton Massimo Mischi 《Ultrasound in medicine & biology》2019,45(2):539-548
Dynamic contrast-enhanced ultrasound (DCE-US) has been proposed as a powerful tool for cancer diagnosis by estimation of perfusion and dispersion parameters reflecting angiogenic vascular changes. This work was aimed at identifying which vascular features are reflected by the estimated perfusion and dispersion parameters through comparison with acoustic angiography (AA). AA is a high-resolution technique that allows quantification of vascular morphology. Three-dimensional AA and 2-D DCE-US bolus acquisitions were used to monitor the growth of fibrosarcoma tumors in nine rats. AA-derived vascular properties were analyzed along with DCE-US perfusion and dispersion to investigate the differences between tumor and control and their evolution in time. AA-derived microvascular density and DCE-US perfusion exhibited good agreement, confirmed by their spatial distributions. No vascular feature was correlated with dispersion. Yet, dispersion provided better cancer classification than perfusion. We therefore hypothesize that dispersion characterizes vessels that are smaller than those visible with AA. 相似文献
104.
105.
Leyi Wang Saraswathi Lanka Debbie Cassout Nohra E. Mateus‐Pinilla Ganwu Li William C. Wilson Dongwan Yoo Paul Shelton Richard L. Fredrickson 《Transboundary and Emerging Diseases》2019,66(5):1809-1820
First described in 1955 in New Jersey, epizootic haemorrhagic disease (EHD) causes a severe clinical disease in wild and domestic ruminants worldwide. Epizootic haemorrhagic disease outbreaks occur in deer populations each year from summer to late autumn. The etiological agent is EHD virus (EHDV) which is a double‐stranded segmented icosahedral RNA virus. EHD virus utilizes point mutations and reassortment strategies to maintain viral fitness during infection. In 2018, EHDV serotype 2 was predominantly detected in deer in Illinois. Whole genome sequencing was conducted for two 2018 EHDV2 isolates (IL41747 and IL42218) and the sequence analyses indicated that IL42218 was a reassortant between different serotypes whereas IL41747 was a genetically stable strain. Our data suggest that multiple strains contribute to outbreaks each year. 相似文献
106.
T.F.A. Lees L. Bogdashich D. Godden 《The British journal of oral & maxillofacial surgery》2021,59(1):e9-e12
Fibroepithelial polyps (FEPs) are common, benign intraoral lesions that tend to develop slowly at predictable sites, often in response to local irritation or trauma. Historical precedent often results in referral to oral and maxillofacial surgery (OMFS) departments for biopsy, often irrespective of symptoms, and histological assessment. OMFS and pathology services are struggling to cope with an increasing workload that will potentially lead to widespread delays to diagnosis and treatment. Over the past 20 years, clinical pathways and guidance have been developed to ensure that healthcare interventions, such as the removal of third molars, tonsils, skin tags, and benign moles, are evidence-based, have a net patient benefit, and ensure the best use of finite NHS resources. However, no such guidance exists for intraoral lesions and we regard this as an oversight. We analysed the removal of 682 FEPs over a seven-year period and report sensitivities of 92.4% for a “confirmed clinical suspicion of an FEP” and 99.7% for a “confirmed clinical suspicion of a benign diagnosis”. The incidence of non-benign disease was 0.3%. Primary care dentists should be able to diagnose and monitor FEPs and refer only if symptoms are serious or in high-risk patients or sites. Adopting this practice across the UK could free up to 1825 four-hour OMFS clinics, 405 hours of consultant histopathologists’ time, and recurring savings to the NHS estimated to be in the region of £620 000/annum. We believe that the removal of FEPs should be reclassified as an “intervention not normally funded”, and the time and resources put to better use treating patients with lesions of questionable pathology. 相似文献
107.
Yang Chih-Hsiang Wang Shirlene Wang Wei-Lin Belcher Britni R. Dunton Genevieve F. 《Journal of behavioral medicine》2022,45(5):702-715
Journal of Behavioral Medicine - Understanding associations between mothers’ and children’s physical activity and sedentary behavior on more fine-grained timescales can provide insights... 相似文献
108.
109.
In both adults and children with diabetes, technologies such as continuous subcutaneous insulin infusion using insulin pumps and continuous glucose monitoring can help improve diabetes control, reduce hypoglycaemia and improve quality of life. Access to these technologies in the UK is very variable. Some technologies are recommended by the National Institute for Health and Care Excellence, while others have not been appraised, and new technologies are emerging all the time. Additionally, different guidelines for adults and children further complicate access to diabetes technology in the transition from paediatric to adult care. Against this background, Diabetes UK and NHS England have brought together a multidisciplinary group of experts, including clinicians and people with diabetes, to develop this consensus guideline, combining the different technologies into a common pathway to aid clinical and policy decision‐making. We created a pathway that supports the incremental addition of technology as monotherapy and then dual therapy in the same way that we incrementally add in therapeutic agents to support people with Type 2 diabetes to achieve their personalized glycaemic targets. The pathway emphasizes the importance of structured education, specialist support and appropriate access to psychological therapies, as essential pillars for optimized use of diabetes‐related technology, and recommends the re‐evaluation of its use when the individual is unable either to use the technology appropriately or to achieve the intended outcomes. This pathway is endorsed by UK‐wide clinical and patient associations and we recommend that providers and commissioners use it to ensure the right individual with diabetes has access to the right technology in a timely way to help achieve better outcomes. 相似文献
110.
Familial risk and heritability of intellectual disability: a population-based cohort study in Sweden