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101.
Keith B. Burt Robert Whelan Patricia J. Conrod Tobias Banaschewski Gareth J. Barker Arun L.W. Bokde Uli Bromberg Christian Büchel Mira Fauth‐Bühler Herta Flor André Galinowski Juergen Gallinat Penny Gowland Andreas Heinz Bernd Ittermann Karl Mann Frauke Nees Dimitri Papadopoulos‐Orfanos Tomas Paus Zdenka Pausova Luise Poustka Marcella Rietschel Trevor W. Robbins Michael N. Smolka Andreas Ströhle Gunter Schumann Hugh Garavan the IMAGEN Consortium 《Journal of child psychology and psychiatry, and allied disciplines》2016,57(11):1287-1296
102.
103.
104.
Katarzyna Niespodziana Katarina Stenberg-Hammar Nikolaos G. Papadopoulos Margarete Focke-Tejkl Peter Errhalt Jon R. Konradsen Cilla Sderhll Marianne van Hage Gunilla Hedlin Rudolf Valenta 《Viruses》2021,13(5)
Allergen exposure and rhinovirus (RV) infections are common triggers of acute wheezing exacerbations in early childhood. The identification of such trigger factors is difficult but may have therapeutic implications. Increases of IgE and IgG in sera, were shown against allergens and the N-terminal portion of the VP1 proteins of RV species, respectively, several weeks after allergen exposure or RV infection. Hence, increases in VP1-specific IgG and in allergen-specific IgE may serve as biomarkers for RV infections or allergen exposure. The MeDALL-allergen chip containing comprehensive panels of allergens and the PreDicta RV chip equipped with VP1-derived peptides, representative of three genetic RV species, were used to measure allergen-specific IgE levels and RV-species-specific IgG levels in sera obtained from 120 preschool children at the time of an acute wheezing attack and convalescence. Nearly 20% of the children (22/120) showed specific IgE sensitizations to at least one of the allergen molecules on the MeDALL chip. For 87% of the children, increases in RV-specific IgG could be detected in the follow-up sera. This percentage of RV-specific IgG increases was equal in IgE-positive and -negative children. In 10% of the children, increases or de novo appearances of IgE sensitizations indicative of allergen exposure could be detected. Our results suggest that, in the majority of preschool children, RV infections trigger wheezing attacks, but, in addition, allergen exposure seems to play a role as a trigger factor. RV-induced wheezing attacks occur in IgE-sensitized and non-IgE-sensitized children, indicating that allergic sensitization is not a prerequisite for RV-induced wheeze. 相似文献
105.
T Balayan J Begovac A Skrzat‐Klapaczyska I Aho I Alexiev P Bukovinova D Salemovic D Gokengin A Harxhi T Holban D Jevtovic K Kase B Lakatos I Latysheva R Matulionyte C Oprea A Papadopoulos N Rukhadze D Sedlacek J Tomazic A Vassilenko M Vasylyev A Verhaz N Yancheva O Yurin A Horban JD Kowalska 《HIV medicine》2021,22(1):67-72
106.
Papadopoulos Esperanza B.; Carabasi Matthew H.; Castro-Malaspina Hugo; Childs Barrett H.; Mackinnon Stephen; Boulad Farid; Gillio Alfred P.; Kernan Nancy A.; Small Trudy N.; Szabolcs Paul; Taylor Joanne; Yahalom Joachim; Collins Nancy H.; Bleau Sharon A.; Black Patricia M.; Heller Glenn; Reilly Richard J.O'; Young James W. 《Blood》1998,91(3):1083-1090
107.
Antiatherogenic effect of Pistacia lentiscus via GSH restoration and downregulation of CD36 mRNA expression 总被引:3,自引:0,他引:3
Dedoussis GV Kaliora AC Psarras S Chiou A Mylona A Papadopoulos NG Andrikopoulos NK 《Atherosclerosis》2004,174(2):293-303
Pistacia lentiscus var. Chia (Anacardiaceae) grows almost exclusively on Chios Island, Greece, and gives a resinous exudate resin used for culinary purposes by Mediterranean people. We investigated the molecular mechanisms through which total polar extract of the resin inhibits oxidized low-density lipoprotein (oxLDL) cytotoxic effect on peripheral blood mononuclear cell (PBMC). Cells exposed to oxLDL underwent apoptosis and necrosis, dependent on the duration of exposure. When culturing cells with oxLDL and the polar extract concurrently, we observed inhibition of both the phenomena. Because under oxidative stress the pro-oxidant systems outbalance the antioxidant, potentially producing oxidative damage and ultimately leading to cell death, we measured the levels of intracellular antioxidant glutathione (GSH). Additionally, we measured CD36 expression, a class B scavenger receptor, on CD14-positive cells, as CD36 has been identified as the oxLDL receptor in macrophages and may play a pivotal role in atherosclerotic foam cell formation. oxLDL decreased GSH levels and upregulated CD36 expression. P. lentiscus extract restored GSH levels and downregulated CD36 expression, even at the mRNA level. In order to find out the biologically drastic constituents of the resin's polar extract, fractions derived from RP-HPLC analysis were examined for their antioxidant effect on oxidatively stressed PBMC. The triterpenoid fraction revealed remarkable increase in intracellular GSH. We suggest GSH restoration and downregulation of CD36 mRNA expression as the pathways via which P. lentiscus triterpenes exert antioxidant/antiatherogenic effect. Additionally, our results provide strong evidence of the resin's antiatherogenic effect; therefore it is credited with beneficial health aspects. 相似文献
108.
Juliane H. Fröhner Stephan Ripke Sarah Jurk Shu-Chen Li Tobias Banaschewski Arun L.W. Bokde Erin Burke Quinlan Sylvane Desrivières Herta Flor Antoine Grigis Hugh Garavan Andreas Heinz Rüdiger Brühl Jean-Luc Martinot Marie-Laure Paillère Martinot Eric Artiges Frauke Nees Dimitri Papadopoulos Orfanos Luise Poustka Sarah Hohmann Henrik Walter Robert Whelan Gunter Schumann Michael N. Smolka the IMAGEN Consortium 《Alcoholism, clinical and experimental research》2022,46(4):667-681
Background
While drinking alcohol, one must choose between the immediate rewarding effects and the delayed reward of a healthier lifestyle. Individuals differ in their devaluation of a delayed reward based on the time required to receive it, i.e., delay discounting (DD). Previous studies have shown that adolescents discount more steeply than adults and that steeper DD is associated with heavier alcohol use in both groups.Methods
In a large-scale longitudinal study, we investigated whether higher rates of DD are an antecedent or a consequence of alcohol use during adolescent development. As part of the IMAGEN project, 2220 adolescents completed the Monetary Choice Questionnaire as a DD measure, the Alcohol Use Disorders Identification Test, and the Timeline Follow Back interview at ages 14, 16, 18, and 22. Bivariate latent growth curve models were applied to investigate the relationship between DD and drinking. To explore the consequences of drinking, we computed the cumulative alcohol consumption and correlated it with the development of discounting. A subsample of 221 participants completed an intertemporal choice task (iTeCh) during functional magnetic resonance imaging at ages 14, 16, and 18. Repeated-measures ANOVA was used to differentiate between high-risk and low-risk drinkers on the development of neural processing during intertemporal choices.Results
Overall, high rates of DD at age 14 predicted a greater increase in drinking over 8 years. In contrast, on average, moderate alcohol use did not affect DD from ages 14 to 22. Of note, we found indicators for less brain activity in top-down control areas during intertemporal choices in the participants who drank more.Conclusions
Steep DD was shown to be a predictor rather than a consequence of alcohol use in low-level drinking adolescents. Important considerations for future longitudinal studies are the sampling strategies to be used and the reliability of the assessments.109.
Influence of T-cell depletion on chronic graft-versus-host disease: results of a multicenter randomized trial in unrelated marrow donor transplantation
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Pavletic SZ Carter SL Kernan NA Henslee-Downey J Mendizabal AM Papadopoulos E Gingrich R Casper J Yanovich S Weisdorf D;National Heart Lung Blood Institute Unrelated Donor Marrow Transplantation Trial 《Blood》2005,106(9):3308-3313
Donor-derived T cells have been proposed to play a role in pathogenesis of chronic graft-versus-host disease (cGVHD). The impact of ex vivo T-cell depletion (TCD) on cGVHD was analyzed in a randomized multicenter trial involving unrelated donor marrow transplants. A total of 404 patients diagnosed with hematologic malignancies received a total body irradiation-based myeloablative conditioning regimen. GVHD prophylaxis included TCD plus cyclosporine (CSA) or unmodified grafts with CSA plus methotrexate (M/C). Median recipient age was 31.2 years (range, 0.5-55.6 years); median follow-up time since randomization was 4.2 years. The mean number of T cells infused was 1 log lower on the TCD arm. The incidence of cGVHD at 2 years was similar between the TCD and M/C arms, 29% versus 34% (P = .27), respectively. Survival at 3 years from diagnosis of cGVHD was also similar, (TCD 51% versus M/C 58%; P = .29). The proportion of patients with cGVHD who discontinued immunosuppression at 5 years was not different (TCD 72% versus M/C 63%; P = .27), and incidence of serious infections and leukemia relapse were similar on both treatment arms. In spite of a significant reduction of acute GVHD, TCD did not reduce the incidence of cGVHD or improve survival in patients who developed cGVHD. 相似文献
110.
Konstantina Papalexopoulou Athanasios Chalkias Ioannis Dontas Paraskevi Pliatsika Charalampos Giannakakos Panagiotis Papapanagiotou Afroditi Aggelina Theodoros Moumouris Georgios Papadopoulos Theodoros Xanthos 《Heart & lung : the journal of critical care》2014