全文获取类型
收费全文 | 15219篇 |
免费 | 914篇 |
国内免费 | 92篇 |
专业分类
耳鼻咽喉 | 90篇 |
儿科学 | 426篇 |
妇产科学 | 358篇 |
基础医学 | 2491篇 |
口腔科学 | 276篇 |
临床医学 | 1344篇 |
内科学 | 3725篇 |
皮肤病学 | 211篇 |
神经病学 | 1939篇 |
特种医学 | 337篇 |
外科学 | 1281篇 |
综合类 | 35篇 |
一般理论 | 4篇 |
预防医学 | 776篇 |
眼科学 | 129篇 |
药学 | 1192篇 |
中国医学 | 30篇 |
肿瘤学 | 1581篇 |
出版年
2024年 | 11篇 |
2023年 | 116篇 |
2022年 | 284篇 |
2021年 | 463篇 |
2020年 | 285篇 |
2019年 | 377篇 |
2018年 | 418篇 |
2017年 | 368篇 |
2016年 | 398篇 |
2015年 | 495篇 |
2014年 | 610篇 |
2013年 | 728篇 |
2012年 | 1213篇 |
2011年 | 1215篇 |
2010年 | 709篇 |
2009年 | 625篇 |
2008年 | 1046篇 |
2007年 | 1041篇 |
2006年 | 1011篇 |
2005年 | 934篇 |
2004年 | 883篇 |
2003年 | 862篇 |
2002年 | 758篇 |
2001年 | 100篇 |
2000年 | 87篇 |
1999年 | 133篇 |
1998年 | 151篇 |
1997年 | 111篇 |
1996年 | 100篇 |
1995年 | 101篇 |
1994年 | 74篇 |
1993年 | 72篇 |
1992年 | 57篇 |
1991年 | 43篇 |
1990年 | 38篇 |
1989年 | 51篇 |
1988年 | 25篇 |
1987年 | 19篇 |
1986年 | 29篇 |
1985年 | 21篇 |
1984年 | 30篇 |
1983年 | 23篇 |
1982年 | 18篇 |
1981年 | 17篇 |
1980年 | 14篇 |
1979年 | 8篇 |
1977年 | 8篇 |
1976年 | 7篇 |
1974年 | 5篇 |
1963年 | 4篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
51.
Evaluation of the BDProbeTec ET system for direct detection of Mycobacterium tuberculosis in pulmonary and extrapulmonary samples: a multicenter study 下载免费PDF全文
Mazzarelli G Rindi L Piccoli P Scarparo C Garzelli C Tortoli E 《Journal of clinical microbiology》2003,41(4):1779-1782
We evaluated the BDProbeTec ET system (Becton Dickinson, Sparks, Md.), a strand displacement amplification-based technique, for direct detection of Mycobacterium tuberculosis in 867 clinical samples. Of 294 extrapulmonary specimens, 52 had positive results by both BDProbeTec ET and culture and 209 had negative results by both methods; sensitivity and specificity were 76.5 and 95.9%, respectively. After resolution of discrepancies, the sensitivity rose to 77.8%. 相似文献
52.
Fausto Sessa Daniela Furlan Anna Genasetti Paola Billo Maddalena Feltri Carlo Capella 《Diagnostic molecular pathology》2003,12(2):96-102
We studied the MSI (microsatellite instability) status and p53 expression in a series of 71 gallbladder cancers (GCs) of different histologic type. All neoplasms were examined combining a microsatellite analysis at mononucleotide locus BAT-26 and an immunohistochemical study for hMSH2, hMLH1, and p53 proteins and markers of gastric and intestinal differentiation. All the 71 GCs were MSS (microsatellite stable). The p53 protein was found in 100% of undifferentiated GCs, 67% of conventional gallbladder adenocarcinomas, 50% of mucinous adenocarcinomas, and 20% GCs with squamous differentiation. All 71 MSS tumors showed presence of immunohistochemical expression of both hMLH1 and hMSH2 gene products. We concluded that microsatellite instability does not play a role in the developing of GC while p53 seems to be the most important alteration found in a large proportion of these cancers, with the only exception of mucinous and squamous gallbladder carcinomas. 相似文献
53.
54.
Sclerosteosis: report of a case in a black African man 总被引:3,自引:0,他引:3
Paolo Tacconi Paola Ferrigno Luigi Cocco Antonino Carinas Giorgio Tamburini Paolo Bergonzi Marcello Giagheddu 《Clinical genetics》1998,53(6):497-501
Sclerosteosis is a rare genetic disorder of bone modelling, similar to, but distinct from, van Buchem disease; it has been described almost exclusively in Afrikaners of South Africa, a white population of Dutch ancestry. Isolated cases have been reported in a girl in Japan, a boy in Spain, and in multiracial families in Brazil and USA.
Here we report a case of sclerosteosis in a black man born in Senegal. He presented with the full features of the disease: tall stature; syndactyly; nail dysplasia; massive sclerosis of the long tubular bones, the ribs, the pelvis and the skull; multiple cranial nerve involvement: optic atrophy, facial palsy and trigeminal neuralgia. Radiologic examination, visual and brainstem auditory evoked potentials, computerized tomography and magnetic resonance imaging of the skull were performed. This seems to be the first case of the disease in a black African individual, with no known relationship with Dutch ancestry. 相似文献
Here we report a case of sclerosteosis in a black man born in Senegal. He presented with the full features of the disease: tall stature; syndactyly; nail dysplasia; massive sclerosis of the long tubular bones, the ribs, the pelvis and the skull; multiple cranial nerve involvement: optic atrophy, facial palsy and trigeminal neuralgia. Radiologic examination, visual and brainstem auditory evoked potentials, computerized tomography and magnetic resonance imaging of the skull were performed. This seems to be the first case of the disease in a black African individual, with no known relationship with Dutch ancestry. 相似文献
55.
Ghiorzo P Villaggio B Sementa AR Hansson J Platz A Nicoló G Spina B Canepa M Palmer JM Hayward NK Bianchi-Scarrà G 《Human pathology》2004,35(1):25-33
Little is known about the correlation between the loss of p16 expression and tumor progression in familial melanoma; no systematic study has been conducted on p16 expression in melanocytic tumors from patients carrying germline CDKN2A mutations. We analyzed 98 early primary lesions from familial patients, previously tested for germline CDKN2A status, by quantitative immunohistochemistry using 3 p16 antibodies. We found that p16 expression was inversely correlated with tumor progression and was significantly lower in melanomas, including in situ lesions, than in nevi. Of other features analyzed, tumor thickness showed the most significant correlation with p16 levels. Lesions from mutation-negative patients displayed combined nuclear and cytoplasmic staining. However, some mutation-positive lesions (ie, G101W, 113insR, M53I, R24P, and 33ins24), including benign nevi, showed nuclear mislocalization, confirming previous studies suggesting that subcellular distribution indicates functional impairment of p16. 相似文献
56.
Paola Origone Carlo Bellini Debora Sambarino Barbara Banelli Guido Morcaldi Carmen La Rosa Franco Stanzial Claudio Castellan Domenico A. Coviello Cecilia Garrè Eugenio Bonioli 《Human mutation》2003,22(4):341-341
In the original version of this article, the title was incorrect. Please find the correct title given here. The publisher deeply regrets this error. The original article to which this Erratum refers was published in Human Mutation 22:179–180 Human Mutation(2003) 22(2) 179–180 相似文献
57.
Malignant granular cell tumor of the lateral femoral cutaneous nerve: report of a case with cytogenetic analysis 总被引:5,自引:0,他引:5
Di Tommaso L Magrini E Consales A Poppi M Pasquinelli G Dorji T Benedetti G Baccarini P 《Human pathology》2002,33(12):1237-1240
Malignant granular cell tumors (MGCTs) are rare neoplasms of uncertain histogenesis. We report a case of MGCT involving a peripheral nerve with peritoneal and omental dissemination in which cytogenetic findings are available. Our results show that MGCTs share some cytogenetic abnormalities with malignant peripheral nerve sheath tumors (MPNSTs), supporting the hypothesis that they may represent histogenetically related lesions. 相似文献
58.
Magdy S. Aly Paola Dal Cin Herman Van Den Berghe Wim Van De Voorde Hein Van Poppel Filip Ameye Luc Baert 《Genes, chromosomes & cancer》1994,9(4):227-233
We combined conventional cytogenetic analysis and fluorescence in situ hybridization of short-term cultures of 28 samples from benign prostatic hyperplasia. Lou of the Y chromosome was the most common chromosome change, followed by trisomy 7. Trisomy 7, however, may be unrelated to the origin of benign prostate hyperplasia, in which the only and not very specific change seems to be the loss of the Y chromosome. Genes Chrom Cancer 9:227-233 (1594). © 1994 Wiley-Liss, Inc. 相似文献
59.
Paola Dal Cin Chris De Wolf-Peeters Magdy S. Aly Georges Deneffe Walter Van Mieghem Herman Van Den Berghe 《Genes, chromosomes & cancer》1993,6(4):243-244
Cytogenetic analysis of a thymoma showed the presence of a ring chromosome 6 as the sole chromosome abnormality. © 1993 Wiley-Liss, Inc. 相似文献
60.
Pagot E Fiedler S Cloetens P Bravin A Coan P Fezzaa K Baruchel J Härtwig J von Smitten K Leidenius M Karjalainen-Lindsberg ML Keyriläinen J 《Physics in medicine and biology》2005,50(4):709-724
Two x-ray phase contrast imaging techniques are compared in a quantitative way for future mammographic applications: diffraction enhanced imaging (DEI) and phase propagation imaging (PPI). DEI involves, downstream of the sample, an analyser crystal acting as an angular filter for x-rays refracted by the sample. PPI simply uses the propagation (Fresnel diffraction) of the monochromatic and partially coherent x-ray beam over large distances. The information given by the two techniques is assessed by theoretical simulations and compared at the level of the experimental results for different kinds of samples (phantoms and real tissues). The imaging parameters such as the energy, the angular position of the analyser crystal in the DEI case or the sample to detector distance in the PPI case were varied in order to optimize the image quality in terms of contrast, visibility and figure of merit. 相似文献