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51.
本文对5例典型尖锐湿疣标本及10例可疑人乳头瘤病毒感染标本进行透射电子显微镜观察。结果典型尖锐湿疣标本中仅1例于细胞核内见到人乳头瘤病毒,排列规则呈结晶状。其余14例标本的细胞内均见不同程度的由病毒感染所引起的非特异性病理变化。本文对人孔头瘤病毒及受感染细胞的超微结构进行了初步探讨。 相似文献
52.
应用单链构象多态性分析多聚酶链反应EB染色法(PCR-SSCP-EB)对40例肺癌组织标本的P53基因序列5~8外显子突变进行分析,同时应用PCR方法检测上述标本及18例肺良性疾病组织标本中HPV16、18型DNA相关序列,旨在分析二者在肺鳞癌发病中的作用及相互关系,并就肺鳞癌与P53基因结构和功能异常的关系进行初步探讨。 相似文献
53.
胚胎颅骨骨膜移植修复髋关节软骨大面积缺损 总被引:9,自引:3,他引:6
1990年5月~1994年4月,对42例(47个髋)关节软骨全厚缺损患者采用冷冻保存胚胎颅骨骨膜移植进行修复,其中14例股骨头骨质Ⅳ期坏死者,同时施行带旋髂深血管蒂髂骨植骨。对34例(38个髋)进行了2年~6年(平均40个月)随访。结果表明,按照吴之康髋关节人工置换术后疗效评定标准,优良25例,很好5例,好3例,尚可1例。认为,与自体移植物修复关节软骨大面积缺损相比,这种方法无附加损伤,具有移植材料、形态与股骨头相似等特点,是治疗髋关节软骨大面积缺损的一种有效方法。 相似文献
54.
目的 了解本社区高血压患者的危险因素现状,探讨干预对策。方法 采用分层整群抽样的方法,随机抽取社区4个里委2级、3级高血压患者402例作为研究对象,收集各项危险因素如性别、年龄、血脂、血糖、吸烟、饮食、体育锻炼、体重等,并进行统计分析。结果402例高血压患者1年内进行所有相关辅助检查者有14例,占3.48%;1年内进行相关辅助检查一项者306例,占76.12%。饮食控制及进行体育锻炼有300例,占74.43%;吸烟62例,占15.42%。结论 高血压患者对饮食控制及体育锻炼、吸烟有害的知晓率明显提高,而对相关辅助检查认识不足。 相似文献
55.
Pan Jing-xin Guo Yi-bin Guo Xi-zhe Guo Jian-xin Chen Yun-feng Wang Zhi-dong 《中国结合医学杂志》2004,10(1):36-39
Objective: To explore the effect of Shenfu Injection, SFI) on the secondary aplastic anemia (AA) of tumor patients after chemotherapy
(CT).Methods: The 15 cases of SFI treated group, 10 cases of control group, 25 cases of SFI + granulocyte-macrophage colony stimulating
factor (GMCSF) treated group and the group of 23 GM-CSF-treated tumor cases of secondary AA after CT were compared, with their
increasing rate and the rebound speed of neutrophil, platelet, bone marrow nucleated RBC, granulocyte, and megakaryocyte all
being investigated.Results: The increasing rate and rebound speed of granulocyte, platelet, and the increasing rate of bone marrow nucleated RBC, granulocyte,
megakaryocyte were obviously higher than those of the control, and the clinical manifestations were also obviously improved.
The increasing rate of platelet, bone marrow nucleated RBC, megakaryocyte of the SFI + GM-CSF group were higher than those
of the group which used GM-CSF alone, while the increasing rate of granulocyte in blood and bone marrow in both groups was
similar.Conclusion: Significant efficacy was shown in SFI for the treatment of secondary AA of tumor patients after CT. 相似文献
56.
Experimental Study on Allogenic Decalcified Bone Matrix as Carrier for Bone Tissue Engineering 总被引:11,自引:0,他引:11
The biocompatibility and osteogenic activity of allogenic decalcified bone matrix (DBM) used as a carrier for bone tissue engineering were studied. Following the method described by Urist, allogenic DBM was made. In vitro, DBM and bone marrow stromal cell (BMSC) from rab-bits were co-cultured for 3-7 days and subjected to HE staining, and a series of histomorphological observations were performed under phase-contrast microscopy and scanning electron microscopy (SEM). In vivo the mixture of DBM/BMSC co-cultured for 3 days was planted into one side of muscules sacrospinalis of rabbits, and the DBM without BMSC was planted into other side as con-trol. Specimens were collected at postoperative week 1, 2 and 4, and subjected to HE staining, and observed under SEM. The results showed during culture in vitro, the BMSCs adherent to the wall of DBM grew, proliferated and had secretive activity. The in vivo experiment revealed that BMSCs and undifferentiated mesenchymal cells in the perivascular region invaded gradually and proliferated together in DBM/BMSC group, and colony-forming units of chondrocytes were found. Osteoblasts,trabecular bone and medullary cavity appeared. The inflammatory reaction around muscles almost disappeared at the second weeks. In pure DBM group, the similar changes appeared from the sur-face of the DBM to center, and the volume of total regenerate bones was less than the DBM/BMSC group at the same time. The results indicated that the mixture of DBM and BMSC had good bio-compatibility and ectopic induced osteogentic activty. 相似文献
57.
The blood–brain barrier (BBB) is an immense neurovascular interface. In neurodegenerative, ischemic, and traumatic disorders of the central nervous system (CNS), the BBB may hinder the delivery of many therapeutic peptides and proteins to the brain and spinal cord. Fortunately, the mistaken dogma that peptides and proteins do not cross the BBB has been corrected during the past two decades by the accumulating evidence that peptides and proteins in the periphery exert potent effects in the CNS. Not only can peptides and proteins serve as carriers for selective therapeutic agents, but they themselves may directly cross the BBB after delivery into the bloodstream. Their passage may be mediated by simple diffusion or specific transport, both of which can be affected by interactions in the blood compartment (outside the BBB) and within the endothelial cells (at the BBB level). Although the majority of current delivery strategies focuses on modification of the molecule to be delivered, understanding the mechanisms of transport will eventually facilitate regulation of the BBB directly. We review the different aspects of interactions and discuss recent advances in the cell biology of peptide/protein transport across the BBB. Better understanding of the nature and regulation of the transport systems at the BBB will provide a new direction to enhance the interactions of peripheral peptides and proteins with the CNS. 相似文献
58.
肾上腺皮质腺癌的诊断与治疗 总被引:2,自引:0,他引:2
目的 探讨肾上腺皮质腺癌的早期诊断、手术及围手术期处理。方法 回顾分析了1990年至2001年间31例肾上腺皮质腺癌临床资料.并与1978年至1989年同种病例作比较。结果 近10年患者病理分期更趋向早期,更易行根治性切除,5年的存活率明显提高。结论 影像学的发展,使患者易早期诊断;围手术期的充分准备是减少手术并发症及死亡率的关键。 相似文献
59.
Accordingtothedatafromepidemiology,thein-cidenceofcancerrisessteadilywithadvancingage.Age?specificincidenceratesfromtheThirdNationalCancerSurveyoftheUnitedStatesrevealedthattheriskofcancerdevelopmentinthe6thdecadeoflifeisapproximately1%,whichincreasesto2%inthe81styearoflife(1).Theincidencesofmostgyneco-logiccancersincludingcervicalcancer,endometrialcancer,ovariancancerandvulvarcancerpeakaftertheageof60years(2-4).Surgeryisoneofthemaintreatmentoptionsforgynecologiccancerandmaybringaboutsomeeff… 相似文献
60.
目的探讨声敏剂血卟啉衍生物在肿瘤组织中的富集情况,以便在给药后超声结合血卟啉治疗肿瘤时选择最佳的超声处理时间。方法H-22肝癌荷瘤小鼠尾静脉注射HpD后,不同时间点取材,采用荧光分光光度法测定不同组织提取液中HpD的荧光强度,研究HpD在不同组织中的分布以及代谢变化。结果给药后2 h肿瘤组织以外的其他各组织内(血浆、肝、肾、皮肤、肌肉)血卟啉含量均达到其代谢过程的最高点,后逐渐下降;肿瘤组织中的HpD含量注射后不断上升,6 h时达到顶峰,随后又开始下降,10~24 h代谢比较缓慢,表现为肿瘤组织中对HpD的滞留作用,24 h时肿瘤组织中的HpD含量高于其他各组织,48~72 h趋于稳定在较低水平。结论提出了不同部位的肿瘤应选择各自适当的时间点进行超声处理。 相似文献