全文获取类型
收费全文 | 2962篇 |
免费 | 86篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 126篇 |
妇产科学 | 108篇 |
基础医学 | 290篇 |
口腔科学 | 75篇 |
临床医学 | 459篇 |
内科学 | 652篇 |
皮肤病学 | 171篇 |
神经病学 | 129篇 |
特种医学 | 18篇 |
外科学 | 373篇 |
综合类 | 54篇 |
一般理论 | 19篇 |
预防医学 | 193篇 |
眼科学 | 78篇 |
药学 | 226篇 |
肿瘤学 | 64篇 |
出版年
2016年 | 26篇 |
2015年 | 35篇 |
2014年 | 27篇 |
2013年 | 66篇 |
2012年 | 27篇 |
2010年 | 79篇 |
2009年 | 91篇 |
2008年 | 29篇 |
2007年 | 27篇 |
2006年 | 27篇 |
2003年 | 18篇 |
2001年 | 31篇 |
2000年 | 26篇 |
1999年 | 71篇 |
1998年 | 108篇 |
1997年 | 149篇 |
1996年 | 144篇 |
1995年 | 105篇 |
1994年 | 89篇 |
1993年 | 80篇 |
1992年 | 87篇 |
1991年 | 73篇 |
1990年 | 73篇 |
1989年 | 79篇 |
1988年 | 85篇 |
1987年 | 64篇 |
1986年 | 72篇 |
1985年 | 60篇 |
1984年 | 68篇 |
1983年 | 42篇 |
1982年 | 56篇 |
1981年 | 64篇 |
1980年 | 56篇 |
1979年 | 43篇 |
1978年 | 38篇 |
1977年 | 34篇 |
1976年 | 28篇 |
1975年 | 25篇 |
1974年 | 20篇 |
1972年 | 21篇 |
1971年 | 19篇 |
1970年 | 28篇 |
1959年 | 37篇 |
1958年 | 68篇 |
1957年 | 79篇 |
1956年 | 56篇 |
1955年 | 55篇 |
1954年 | 70篇 |
1949年 | 35篇 |
1948年 | 55篇 |
排序方式: 共有3049条查询结果,搜索用时 0 毫秒
71.
72.
PETER D. SKILLINGTON DAVID C. McGIFFIN RICHARD KEMP J. H. N. BETT GEOFFREY HOLT ROSS FORGAN-SMITH 《Internal medicine journal》1988,18(7):872-873
A 30 year old veterinary surgeon developed a febrile illness with serological evidence of Brucellosis. He was known to have aortic valve disease and during the course of the illness, the clinical features of endocarditis became evident, with a vegetation visible echocardiographically on the aortic valve. Because of persisting fever despite appropriate antibiotic therapy, aortic valve replacement with a viable cryopreserved allograft aortic valve was undertaken. Organisms consistent with Brucella species were demonstrated in the excised vegetation. The patient received a six week course of antibiotics and his post-operative course was uneventful. 相似文献
73.
HEIDI ALLEN BILL J. WRIGHT KRISTIN HARDING LAUREN BROFFMAN 《The Milbank quarterly》2014,92(2):289-318
Context
The Affordable Care Act provides new Medicaid coverage to an estimated 12 million low-income adults. Barriers to access or quality could hamper the program''s success. One of these barriers might be the stigma associated with Medicaid or poverty.Methods
Our mixed-methods study involved 574 low-income adults and included data from an in-person survey and follow-up interviews. Our analysis of the interviews showed that many participants who were on Medicaid or uninsured described a perception or fear of being treated poorly in the health care setting. We defined this experience as stigma and merged our qualitative interviews coded for stigma with our quantitative survey data to see whether stigma was related to other sociodemographic characteristics. We also examined whether stigma was associated with access to care, quality of care, and self-reported health.Findings
We were unable to identify other sociodemographic characteristics associated with stigma in this low-income sample. The qualitative interviews suggested that stigma was most often the result of a provider-patient interaction that felt demeaning, rather than an internalized sense of shame related to receiving public insurance or charity care. An experience of stigma was associated with unmet health needs, poorer perceptions of quality of care, and worse health across several self-reported measures.Conclusions
Because a stigmatizing experience in the health system might interfere with the delivery of high-quality care to new Medicaid enrollees, further research and policy interventions that target stigma are warranted. 相似文献74.
‘Dose response’ refers to the regression of a response on a stimulus. We review a number of options for dose–response designs, and compare various designs which may be used in practice. We start with two group designs. Next, we introduce basic optimal approximate design theory for simple linear and quadratic regression illustrating different criteria of optimality and their effect on the allocation of the levels of the dose. Then we obtain the efficiencies of these optimal approximate designs and some simple designs which have intuitive appeal (symmetry, equal spacing of treatments, reduced numbers of observations at the highest and lowest doses). 相似文献
75.
Birthweight distributions have been conceptualized as a predominant Gaussian distribution contaminated in the tails by an unspecified ‘residual’ distribution. Acknowledging this idea, we propose a technique for measuring certain features of birthweight distributions useful to epidemiologists: the mean and variance of the predominant distribution; the proportions of births in the low- and high-birthweight residual distributions, and the boundaries of support for these residual distributions. Our technique, based on an underlying multinomial sampling distribution, involves estimating parameters in a mixture model for the multinomial bin probabilities after having chosen the support of the residual distribution with a model selection criterion. A modest simulation study and experience with a few actual datasets indicate that use of a Bayesian information criterion (BIC) as model selection criterion is superior to use of Akaike's information criterion (AIC) in this application. 相似文献
76.
CHRISTIANE KENCK M
NICA WILHELM PETER BUGERT GERD STAEHLER GYULA KOVACS 《The Journal of pathology》1996,179(2):157-161
To define the possible role of the VHL gene in the development of sporadic renal cell carcinomas, 91 different parenchymal tumours of the kidney have been investigated for mutation of the VHL gene by single strand conformation polymorphism (SSCP) and/or heteroduplex (HD) techniques. Chromosome 3p deletion was detected in 98 per cent of non-papillary renal cell carcinomas and in 25 per cent of chromophobe renal cell carcinomas. In 22 of the 43 non-papillary renal cell carcinomas, abnormally migrating DNA bands were detected by SSCP and/or HD analysis. No mobility shift was seen in any of the 23 chromophobe renal cell carcinomas. In addition, 15 papillary renal cell tumours and ten renal oncocytomas, which are characterized by genetic changes other than loss of chromosome 3p sequences, were analysed for mutation of the VHL gene. None of these tumours showed abnormal migration patterns. The results indicate that mutation of the VHL gene is associated exclusively with the development of non-papillary renal cell carcinoma. 相似文献
77.
The aim of this study was to evaluate the utility of a new monoclonal antibody (AER311) that targets the oestrogen receptor (ER) in an immunohistochemical assay (IHA) applied to breast cancers. Ninety-seven cases of invasive ductal carcinoma were studied by AER311-IHA using a pressure-cooking antigen retrieval technique applied to formaldehyde-fixed, paraffin-embedded tissue sections; immunostaining was assessed by semi-quantitative scoring ( H score). There was 80 per cent concordance between the ER status measured by dextran-coated charcoal (DCC) assay and AER311-IHA, with 63/97 (65 per cent) tumours positive and 15/97 (15 per cent) tumours negative by both assays. Of the 12 DCC-positive cases that were negative by AER311-IHA, 11 were borderline positive (3–8 fmol/mg). Similarly, six of seven DCC-negative cases that scored positive by AER311-IHA had only borderline positive H scores (<50). When AER311-IHA was compared with 1D5-IHA, there was good concordance in ER status (77 per cent) and a significant correlation ( r =0·7, P <0·001) between H scores. Nevertheless, the correlation between ER level determined by AER311-IHA and that measured by DCC ( r =0·53, P <0·001) was higher than that for 1D5-IHA ( r =0·32, P =0·002). AER311-IHA can therefore provide reliable information about the ER status of breast carcinoma on paraffin sections and is an acceptable alternative to other commercially available monoclonal antibodies. 相似文献
78.
Influence of Zoledronic Acid on Atrial Electrophysiological Parameters and Electrocardiographic Measurements 下载免费PDF全文
79.
80.
Intestinal ischaemia associated with carcinoid tumour: A case report with review of the pathogenesis 总被引:1,自引:0,他引:1
J. R. BESSELL A. KARATASSAS P. W. ALLEN 《Journal of gastroenterology and hepatology》1994,9(3):304-307
A case of ischaemic ileal perforation associated with a macroscopically unapparent ileal carcinoid is described. The mesenteric vessels were non-pulsatile at operation but were anatomically patent when examined by the pathologist. The characteristic elastic perivascular sclerosis of mesenteric vessels, which probably caused a functional vascular obstruction, was only discovered after the histological sections were reviewed. The true incidence of this rare condition may be higher than previously suspected because the perivascular sclerosis can easily be overlooked. Awareness of the association between carcinoid tumour and mesenteric ischaemia may lead to early surgery and an improved outcome. 相似文献