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921.
Cagdas Eker Omer Kitis Fatma Taneli Ozlem Donat Eker Erol Ozan Kaan Yucel Kerry Coburn Ali Saffet Gonul 《European archives of psychiatry and clinical neuroscience》2010,260(7):527-533
The hippocampus seems to be affected in MDD, and brain-derived neurotrophic factor (BDNF) has positive effects on neurogenesis
within the hippocampus. Although there are inconsistencies among study results, a smaller hippocampal volume in depressed
patients is thought to be related to the pathophysiology of the disease. We looked at the correlation between serum BDNF (sBDNF)
levels and hippocampal volumes (HCV) of first-episode MDD patients (18 female, 7 male; mean age = 32.1 ± 9.3) and healthy
controls (17 female, 5 male; mean age = 29.7 ± 6.4). Region of interest analysis was conducted on the images acquired via
MRI. sBDNF levels and HCV correlated only in the MDD group (right: r = 0.46, P = 0.02; left: r = 0.47, P = 0.02); however, HCV did not differ between MDD patients and healthy controls (right: F = 2.45, df = 1.46, P > 0.05; left: F = 0.05, df = 1.46, P > 0.05). BDNF may be a factor underlying HCV differences between MDD and healthy control subjects, which become apparent
as severe and multiple episodes are experienced. 相似文献
922.
923.
Abdi Elmi Eleanor Watson Pamela Sandu Ozan Gundogdu Dominic C. Mills Neil F. Inglis Erin Manson Lisa Imrie Mona Bajaj-Elliott Brendan W. Wren David G. E. Smith Nick Dorrell 《Infection and immunity》2012,80(12):4089-4098
Campylobacter jejuni is the most prevalent cause of food-borne gastroenteritis in the developed world; however, the molecular basis of pathogenesis is unclear. Secretion of virulence factors is a key mechanism by which enteric bacterial pathogens interact with host cells to enhance survival and/or damage the host. However, C. jejuni lacks the virulence-associated secretion systems possessed by other enteric pathogens. Many bacterial pathogens utilize outer membrane vesicles (OMVs) for delivery of virulence factors into host cells. In the absence of prototypical virulence-associated secretion systems, OMVs could be an important alternative for the coordinated delivery of C. jejuni proteins into host cells. Proteomic analysis of C. jejuni 11168H OMVs identified 151 proteins, including periplasmic and outer membrane-associated proteins, but also many determinants known to be important in survival and pathogenesis, including the cytolethal distending toxin (CDT). C. jejuni OMVs contained 16 N-linked glycoproteins, indicating a delivery mechanism by which these periplasm-located yet immunogenic glycoproteins can interact with host cells. C. jejuni OMVs possess cytotoxic activity and induce a host immune response from T84 intestinal epithelial cells (IECs), which was not reduced by OMV pretreatment with proteinase K or polymyxin B prior to coincubation with IECs. Pretreatment of IECs with methyl-beta-cyclodextrin partially blocks OMV-induced host immune responses, indicating a role for lipid rafts in host cell plasma membranes during interactions with C. jejuni OMVs. OMVs isolated from a C. jejuni 11168H cdtA mutant induced interleukin-8 (IL-8) to the same extent as did wild-type OMVs, suggesting OMV induction of IL-8 is independent of CDT. 相似文献
924.
Cryptosporidium is an intracellular protozoan parasite that causes gastroenteritis in human. In immunocompromised individuals, cryptosporidium causes far more serious disease. There is no effective specific therapy for cryptosporidiosis, and spontaneous recovery is the rule in healthy individuals. However, immunocompromised patients need effective and prolonged therapy. Here, we present our clinical experience in a six-yr-old boy who underwent living-related donor renal transplantation and who was infected with Cryptosporidium spp. Our patient was successfully treated with antimicrobial agents consisting of spiramycin, nitazoxanide, and paromomycin. At the end of second week of therapy, his stool became negative for Cryptosporidium spp. antigen and spiramycin was discontinued. Nitazoxanide and paromomycin treatment was extended to four wk. With this case, we want to emphasize that cryptosporidiosis should be considered in the differential diagnosis of severe or persistent diarrhea in solid organ transplant recipients where rigorous antimicrobial therapy is needed. 相似文献
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926.
Background
The probability of a positive effect of carbon dioxide (CO2) gas on the physiologic oxidative lipolytic process led to its use for localized adiposities. The authors considered that existing studies on CO2 therapy were not sufficient to exhibit the efficiency of CO2 therapy. The scientific basis for evaluating CO2 therapy including standard dietary regimen, standard daily physical effort, and standard psychosocial stimuli was not clear. Despite this unclear situation, CO2 therapy is extremely popular worldwide. The authors designed an experimental study using histomorphologic examination and the laser-Doppler flow meter to monitor treated tissue in rats. They devised a controlled applicator device appropriate for gas injection of rats and compared biochemical effects between CO2 and breathable air. 相似文献927.
Atamer A Alisir Ecder S Akkus Z Kocyigit Y Atamer Y Ilhan N Ecder T 《The Journal of international medical research》2008,36(3):522-528
This study examined the relationship between leptin, insulin-like growth factor-1 (IGF-1), IGF binding protein-3 (IGFBP-3) and insulin resistance in patients with chronic kidney disease (CKD). Levels of leptin, insulin, IGF-1, IGFBP-3 and common routine parameters were measured in 45 patients (23 males and 22 females) with CKD and 45 healthy controls matched for age, gender and body mass index. IGF-1 and IGFBP-3 levels were measured using a two-site immunoradiometric assay. Leptin levels were measured using an enzyme-linked immunosorbent assay. A homeostasis model assessment computer-solved model was used to assess insulin resistance (HOMA-IR). Levels of serum leptin, insulin, IGF-1, IGFBP-3 and HOMA-IR were significantly increased in patients with CKD compared with healthy subjects, whereas fasting blood glucose was not significantly different between the two groups. In patients with CKD, the serum leptin level was significantly correlated with IGF-1, IGFBP-3 and HOMA-IR. In conclusion, this study suggests that there is an interaction between leptin, IGF-1, IGFBP-3 and insulin resistance in patients with CKD. 相似文献
928.
Effect of propolis on oxidative stress and histomorphology of liver tissue in experimental obstructive jaundice 总被引:1,自引:0,他引:1
929.
930.