全文获取类型
收费全文 | 3336篇 |
免费 | 265篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 38篇 |
儿科学 | 84篇 |
妇产科学 | 72篇 |
基础医学 | 491篇 |
口腔科学 | 68篇 |
临床医学 | 367篇 |
内科学 | 697篇 |
皮肤病学 | 77篇 |
神经病学 | 353篇 |
特种医学 | 57篇 |
外科学 | 359篇 |
综合类 | 27篇 |
预防医学 | 412篇 |
眼科学 | 61篇 |
药学 | 233篇 |
中国医学 | 16篇 |
肿瘤学 | 196篇 |
出版年
2024年 | 11篇 |
2023年 | 72篇 |
2022年 | 120篇 |
2021年 | 232篇 |
2020年 | 140篇 |
2019年 | 149篇 |
2018年 | 182篇 |
2017年 | 108篇 |
2016年 | 114篇 |
2015年 | 102篇 |
2014年 | 145篇 |
2013年 | 167篇 |
2012年 | 258篇 |
2011年 | 265篇 |
2010年 | 146篇 |
2009年 | 121篇 |
2008年 | 158篇 |
2007年 | 157篇 |
2006年 | 144篇 |
2005年 | 137篇 |
2004年 | 125篇 |
2003年 | 90篇 |
2002年 | 77篇 |
2001年 | 20篇 |
2000年 | 29篇 |
1999年 | 21篇 |
1998年 | 13篇 |
1997年 | 14篇 |
1996年 | 12篇 |
1995年 | 15篇 |
1993年 | 13篇 |
1992年 | 12篇 |
1991年 | 20篇 |
1990年 | 21篇 |
1989年 | 13篇 |
1988年 | 15篇 |
1987年 | 20篇 |
1986年 | 14篇 |
1985年 | 12篇 |
1983年 | 10篇 |
1982年 | 6篇 |
1981年 | 12篇 |
1979年 | 6篇 |
1978年 | 7篇 |
1977年 | 9篇 |
1975年 | 8篇 |
1974年 | 10篇 |
1973年 | 7篇 |
1972年 | 6篇 |
1965年 | 6篇 |
排序方式: 共有3608条查询结果,搜索用时 375 毫秒
161.
Diekmann Kristin Kuzma-Kozakiewicz Magdalena Piotrkiewicz Maria Gromicho Marta Grosskreutz Julian Andersen Peter M. de Carvalho Mamede Uysal Hilmi Osmanovic Alma Schreiber-Katz Olivia Petri Susanne Körner Sonja 《Journal of neurology》2020,267(7):2130-2141
Journal of Neurology - Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with loss of muscle function. The pathogenesis is still unclear and the heterogeneity of ALS... 相似文献
162.
163.
164.
165.
166.
167.
Thomas W. Laver Matthew N. Wakeling Olivia Knox Kevin Colclough Caroline F. Wright Sian Ellard Andrew T. Hattersley Michael N. Weedon Kashyap A. Patel 《Diabetes》2022,71(5):1128
Maturity-onset diabetes of the young (MODY) is an autosomal dominant form of monogenic diabetes, reported to be caused by variants in 16 genes. Concern has been raised about whether variants in BLK (MODY11), KLF11 (MODY7), and PAX4 (MODY9) cause MODY. We examined variant-level genetic evidence (cosegregation with diabetes and frequency in population) for published putative pathogenic variants in these genes and used burden testing to test gene-level evidence in a MODY cohort (n = 1,227) compared with a control population (UK Biobank [n = 185,898]). For comparison we analyzed well-established causes of MODY, HNF1A, and HNF4A. The published variants in BLK, KLF11, and PAX4 showed poor cosegregation with diabetes (combined logarithm of the odds [LOD] scores ≤1.2), compared with HNF1A and HNF4A (LOD scores >9), and are all too common to cause MODY (minor allele frequency >4.95 × 10−5). Ultra-rare missense and protein-truncating variants (PTV) were not enriched in a MODY cohort compared with the UK Biobank population (PTV P > 0.05, missense P > 0.1 for all three genes) while HNF1A and HNF4A were enriched (P < 10−6). Findings of sensitivity analyses with different population cohorts supported our results. Variant and gene-level genetic evidence does not support BLK, KLF11, or PAX4 as a cause of MODY. They should not be included in MODY diagnostic genetic testing. 相似文献
168.
169.
In vitro and in vivo trypanocidal effect of lipophilic extracts of medicinal plants from Mali and Burkina Faso 总被引:1,自引:0,他引:1
AIM OF THE STUDY: To determine the in vitro and in vivo antitrypanosomal activity of extracts of traditionally used plants. MATERIALS AND METHODS: 47 dichloromethane extracts were tested in vitro in the Long-term Viability Assay (LtVA) on Trypanosoma brucei brucei. The most active ones were also tested in vivo using a standardised mouse test. RESULTS: 13 extracts (28%) were active in vitro with MIC-values=100mug/ml, 6 extracts showed MIC-values=50mug/ml. The root extract of Securidaca longepedunculata Fresen. (Polygalaceae) and the leaf extract of Guiera senegalensis J. F. Gmel. (Combretaceae) were able to reduce parasitaemia in mice, experimentally infected with Trypanosoma brucei brucei by 48 and 42% at the dose of 150mg/kg b.w. intraperitoneally, two times daily for 3 days. The extract of Acacia nilotica Delile (Mimosaceae) stem bark showed immunosuppressive effect in vivo. CONCLUSION: The results confirm an effect of the ethnobotanically used plants. Further investigation is needed to optimize the effectiveness of the extracts. 相似文献
170.
Mauro Pulin Kilian E. Stockhausen Olivia A. Masseck Martin Kubitschke Bjrn Busse J. Simon Wiegert Thomas G. Oertner 《Biomedical optics express》2022,13(2):777
Fluorescent proteins are excited by light that is polarized parallel to the dipole axis of the chromophore. In two-photon microscopy, polarized light is used for excitation. Here we reveal surprisingly strong polarization sensitivity in a class of genetically encoded, GPCR-based neurotransmitter sensors. In tubular structures such as dendrites, this effect led to a complete loss of membrane signal in dendrites running parallel to the polarization direction of the excitation beam. To reduce the sensitivity to dendritic orientation, we designed an optical device that generates interleaved pulse trains of orthogonal polarization. The passive device, which we inserted in the beam path of an existing two-photon microscope, removed the strong direction bias from fluorescence and second-harmonic (SHG) images. We conclude that for optical measurements of transmitter concentration with GPCR-based sensors, orthogonally polarized excitation is essential. 相似文献