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71.
The approval of the novel long-acting HIV injection; Cabenuva®- Cabotegravir and Rilpivirine injectable formulation) and the recent call by the World Health Organization for promoting community-based ART management, underscore the remarkable progress towards meeting the Joint United Nations Programme on HIV/AIDS (UNAIDS) 95–95–95 targets by 2030.As the availability of antiretroviral therapy (ART) for the treatment of HIV/AIDS has increased in resource-limited settings, there has been a move to develop and implement alternative treatment delivery models such as Differentiated Service Delivery (DSD) in high prevalence countries to meet the global targets for HIV treatment while maintaining the quality of care. However, there is limited data on the involvement of community pharmacies in the delivery of ART within the community. Although, in western countries, several studies have documented the different roles community pharmacists can play in the management of HIV/AIDS. Community pharmacists are the most accessible and first points of health care for most clients. They are trusted, highly trained health care professionals. They should be incorporated and allowed to administer the Cabenuva® injection if the battle against the HIV pandemic is to be totally won. In this paper, we, therefore, aim to explore how the community pharmacist can be positioned in HIV service delivery regarding the administration of the Novel long-acting Cabenuva® injection formulation. It is therefore recommended that the Nigerian government embrace community pharmacy-led drug administration initiatives and embark on accredited training programmes for the profession in line with drug administration services. The government should also put in place necessary funding mechanisms for community pharmacists for the extra workload placed on them in administering injection drug formulation in their respective pharmacies. 相似文献
72.
Odedina FT Dagne G Pressey S Odedina O Emanuel F Scrivens J Reams RR Adams A Larose-Pierre M 《Infectious agents and cancer》2011,6(Z2):S10
Background
Since behavioral factors are significant determinants of population health, addressing prostate cancer (CaP)-related health beliefs and cultural beliefs are key weapons to fight this deadly disease. This study investigated the health beliefs and cultural beliefs of black men relative to CaP, and the key socio-demographic correlates of these beliefs.Methods
The study design was a cross-sectional survey of 2,864 Florida black men, age 40 to 70, on their perceived susceptibility, perceived severity, attitude, outcomes beliefs, perceived behavioral control, CaP fatalism, religiosity, temporal orientation, and acculturation relative to CaP screening and prevention.Results
The men reported favorable attitude and positive outcome beliefs, but moderate perceived behavioral control, CaP susceptibility and CaP severity. They also had low level of acculturation, did not hold fatalistic beliefs about CaP, had high religious coping skills and had high future time perspective. Several demographic variables were found to be associated with health beliefs and cultural beliefs.Discussion
Our study provides rich data with regard to the health and cultural beliefs that might serve to inform the development of CaP control initiative for US-born and foreign-born black men.73.
74.
Clement?A?AdebamowoEmail author Temidayo?O?Ogundiran Adeniyi?A?Adenipekun Rasheed?A?Oyesegun Oladapo?B?Campbell Effiong?E?Akang Charles?N?Rotimi Olunfunmilayo?I?Olopade 《Breast cancer research : BCR》2002,5(2):R18
Background
The aim of this study was to examine the relationship between waist–hip ratio and the risk of breast cancer in an urban Nigerian population. 相似文献75.
O T Oladapo A O Sule-Odu O J Daniel T A Fakoya 《Journal of obstetrics and gynaecology》2005,25(1):44-48
The sexual behaviour and contraceptive practice of 498 clinical students of a randomly selected medical college in Southwest Nigeria was studied in June 2003. More than two-thirds (67.5%) of the students had (ever had) sexual intercourse while 49.8% of them had ever used contraception. Only 26.1% of the 119 sexually active students used contraception during their last sexual intercourse. The most common contraceptive methods ever used by the students were the condom (54.6%) and rhythm method (39.5%) though a third of them incorrectly identified the limits of the fertile period. Contraception for single sexually active students was disapproved by 11.2% of the participants while 9.8% of them regarded avoidance of HIV patients in the hospital as a preventive measure against HIV infection. This survey reinforces the need for integration of a suitable sexuality course into our medical undergraduate curriculum in order to facilitate the delivery of reproductive health programmes in the future. 相似文献
76.
In vitro and in vivo cytotoxic activity of native and ricin conjugated monoclonal antibodies to HBs antigen for Alexander primary liver cell carcinoma cells and tumours.
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In in vitro and in vivo systems, native or ricin conjugated monoclonal anti-HBs, are capable of inhibiting or slowing the growth of Alexander primary hepatocellular carcinoma cells. Failure of the immune response to this component of the hepatitis B virus may be one permissive factor in the development of some primary liver cell carcinoma in chronic HBV carriers. 相似文献
77.
A survey of 333 pregnant women receiving antenatal care at the primary healthcare centres in Sagamu Local Government Area of Ogun State, southwest Nigeria was conducted between January and March 2005 to assess the acceptability of prenatal HIV screening among them. A total of 325 (97.8%) of the respondents were aware of HIV/AIDS but only 181 (54.3%) of them believed it is a problem in Nigeria. A total of 257 (77.2%) respondents agreed to undergo voluntary counselling and HIV testing (VCT). Multivariate logistic regression analysis of associated factors indicated that being married, self-perception of no risk of HIV infection, awareness of benefits of prenatal HIV testing and Christianity are independent predictors of acceptance of prenatal HIV testing in this population. Most of the respondents (78.9%) who were unwilling to take the test cited fear of being infected with its consequences of stigma and discrimination as the reason for their attitude. The survey suggests that a successful integration of VCT programme into the existing primary healthcare services for prevention of vertical HIV transmission is feasible in this part of Nigeria. 相似文献
78.
Sotimehin SA Runsewe-Abiodun TI Oladapo OT Njokanma OF Olanrewaju DM 《Annals of tropical paediatrics》2007,27(4):297-301
OBJECTIVE: To assess the performance of OptiMAL, a rapid malaria antigen capture dipstick, in diagnosing congenital malaria. METHODS: Live newborns aged 0-3 days, delivered at Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria between August 2004 and January 2005, were screened for malaria parasitaemia with an immunochromatographic test (OptiMAL) and blood film microscopy. OptiMAL detects plasmodium lactate dehydrogenase (pLDH). RESULTS: Twenty-one of 192 newborns (10.9%) were diagnosed with congenital malaria by blood film microscopy. The OptiMAL test was negative in all infants. CONCLUSION: OptiMAL rapid malaria antigen capture dipstick might not be useful for diagnosing malaria parasitaemia in newborns. Blood film microscopy remains the gold standard for the diagnosis of congenital malaria. 相似文献
79.
Huo D Kim HJ Adebamowo CA Ogundiran TO Akang EE Campbell O Adenipekun A Niu Q Sveen L Fackenthal JD Fackenthal DL Das S Cox N Di Rienzo A Olopade OI 《Breast cancer research and treatment》2008,110(2):367-376
The UDP-glucuronosylatransferase 1A1 (UGT1A1) gene is involved in the metabolism of estrogen and detoxification of potential carcinogens. The number of TA repeats in the promoter region of UGT1A1 has been linked to breast cancer risk, but results varied by race. We performed a comprehensive assessment of genetic polymorphisms in the UGT1A1 gene, and examined these polymorphisms and TA repeats in relation to breast cancer risk in a case-control study in Nigeria. 512 breast cancer cases and 226 community controls were genotyped for UGT1A1. Compared with high-activity TA repeat genotypes, the odds ratios (OR) for low-activity and moderate-activity genotypes were 0.47 (95% confidence interval CI, 0.26-0.83) and 0.64 (95% CI, 0.39-1.06), respectively, in premenopausal women (P = 0.009 for trend), but no association was observed in postmenopausal women (P = 0.24). The effect of TA repeats was also differentiated by age: the OR was 0.39 (95% CI 0.21-0.71) for low-activity genotypes and 0.58 (95% CI 0.33-1.00) for moderate-activity genotypes in women <45 years old (P = 0.002 for trend), but no association was observed in women >/=45 years old (P = 0.15). Haplotype analysis showed that UGT1A1 haplotypes were highly diverse with blocked structures. We found a specific haplotype in block 2 that was significantly associated with a 2.1-fold elevated risk (95% CI 1.05-4.39; P = 0.04). In contrast with previous studies, we found low-activity TA repeat alleles were protective against breast cancer among premenopausal indigenous Africans, suggesting that the role of UGT1A1 in breast cancer development may vary by population, presumably due to different environmental and genetic modifier effects. 相似文献
80.
Olufemi T Oladapo Olalekan O Adetoro Oluwarotimi Fakeye Bissallah A Ekele Adeniran O Fawole Aniekan Abasiattai Oluwafemi Kuti Jamilu Tukur Adedapo BA Ande Olukayode A Dada 《Reproductive health》2009,6(1):1-11