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Aim of the work
To evaluate the effects of early and regular treatment with Disease Modifying Anti-Rheumatic Drugs (DMARDs) on disease outcome in rheumatoid arthritis (RA) patients and factors affecting adherence to treatment.Patients and methods
Sixty-four RA patients (83% females, mean age 42.9 ± 11.9 and disease duration 4.5 ± 2 years) were divided into Group A (n = 31) who received DMARDs within 6 months of symptom onset and Group B (n = 33) who received DMARDs later in the disease course. Patients were assessed by the disease activity score DAS28, the Modified Health Assessment Questionnaire-Disability Index (MHAQ-DI), the Physical Component Summary (PCS) and Mental Component Summary (MCS) of the Short Form-36 and scoring of radiological damage by modified Larsen’s method. Adherence was assessed by self-report and physician judgment. A questionnaire including the most important factors that may affect early and regular treatment by DMARDs/appointment keeping of follow up visits was administered to the patients.Results
The adherence rate was 62.5%. Group A patients had significantly lower DAS28, MHAQ-DI, radiological scores (P = 0.001 for all), higher PCS (P = 0.001) and MCS (P = 0.003) scores than group B patients. Among groups A and B, adherent patients had significantly lower DAS28 (P = 0.001 for both) and higher PCS (P = 0.002 and 0.04, respectively) than non-adherent patients. Rural residence, lack of awareness about the disease and lack of belief in medication effectiveness were the most important factors associated with non-adherence (p = 0.04, 0.03 and 0.045, respectively).Conclusion
Early treatment and adherence to DMARDs have an important impact on disease outcome in RA patients. 相似文献Purpose
The purpose of this work was the evaluation of new advances of magnetic resonance imaging (MRI) in diagnosis of recurrent breast cancer after conservative surgery, chemotherapy and radiotherapy.Introduction
Breast conservation surgery followed by breast radiotherapy and chemotherapy produces changes on both physical examination and on post-treatment breast imaging. Distinguishing these normal treatment-related findings from breast cancer recurrence in the original lumpectomy site or elsewhere in the breast (new primary tumors) is challenging.Our prospective study is done on fifty female patients who had undergone breast-conserving therapy at least 6 months since the end of radiation therapy. All cases were suspected for either recurrence or post-operative complications by clinical examination in conjunction with mammography and/or US. Confirmation of different lesions was achieved by fine needle aspiration biopsy, core or excisional biopsy. All patients were examined by dynamic contrast enhanced MRI (DCE-MRI). If one of imaging modalities suspected recurrence, all of the imaging modalities were performed.From our study we concluded that MRI is useful examination that can provide very valuable information in patient with suspected recurrence. It is a technique that offers not only information on lesion cross sectional morphology but also on functional lesion features such as tissue perfusion and enhancement kinetics. 相似文献Method: The registry collects data from both professionals and patients through questionnaires. A total of 33,870 tonsil surgeries were analysed, comprising approximately 80% of all tonsil surgeries in Sweden from 2013 to 2015.
Results: The two most common procedures were tonsillectomy (41%) and tonsillotomy with adenoidectomy (38%). Tonsillectomy was most commonly performed to treat frequent tonsillitis, while the main indication for tonsil surgery with combined adenoidectomy and for tonsillotomy alone was upper airway obstruction. The most commonly used techniques were cold steel (70%) for tonsillectomy/adenotonsillectomy and radiofrequency (79%) for tonsillotomy/adenotonsillotomy. Ninety-five percent of patients reported symptom relief after 180 d. Day surgery was utilised in 70% of the surgeries. The rate of readmission due to post-tonsillectomy haemorrhage was 5.1%. Male patients more often underwent tonsil surgery at preschool ages due to upper airway obstruction; in comparison, female patients to a larger extent underwent surgery in their early teens because of previous infections.
Conclusions: The NTSRS provides an opportunity to survey tonsil surgery in Sweden and to launch and follow up improvement programmes as desired. 相似文献