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71.
B7-1和IL-12基因转染对肝癌细胞免疫原性的影响 总被引:2,自引:1,他引:1
目的 观察B7-1和IL-12基因表达对人肝癌细胞免疫原性原影响。方法 分别将B7-1和IL-12基因以逆转录病毒介导转染HepG2细胞。阳性克隆细胞与健康人外周血淋巴细胞(PBL)混合培养后,用流式细胞仪检测PBL表面Ⅰ类人白细胞抗原(HLA-Ⅰ)分子表达,以MTT法检测PBL的特异性杀伤活性K562细胞的活性。结果 混合HepG2/B7-1HepG2/IL-12细胞组PBL表面的HLA-Ⅰ分子 相似文献
72.
D. D. Ohnmeiss Heikki Vanharanta Ann-Mari Estlander Ari Jämsén 《European spine journal》2000,9(3):208-212
There was much enthusiasm about the development of computerized dynamometry in providing large quantities of data to objectively
assess muscle performance. However, a much more basic issue arose questioning what these machines actual measure, particularly
in pain populations. The purpose of the present study was to determine whether patients’ self-reported disability and pain
expression, as evaluated with simple questionnaires, were related to isokinetic performance in low back pain patients. Method: Oswestry Disability Questionnaires and pain drawings were collected from 76 patients undergoing isokinetic testing upon entering
a physical rehabilitation program. Isokinetic trunk testing was performed in the standing position and results recorded for
flexion and extension at speeds of 50°, 100°, and 150° per second. Results: Patients indicating minimal disability on the Oswestry questionnaire performed better than those indicating greater levels
of disability (P < 0.05; ANOVA with Tukey adjustment for multiple comparisons). Patients with greater pain drawing scores, indicating unusual
pain patterns, performed more poorly during isokinetic testing than those with normal drawings (P < 0.05). Regression analysis revealed that the lifting question from the Oswestry questionnaire, pain drawings scores, and
sex were all significantly related to isokinetic performance and could account for 37.6–48.1% of the variance in performance
(varying with speed of test). Conclusions: The results of this study indicate that isokinetic test values are significantly influenced by a patient’s self-reported
disability and pain expression, which can be evaluated using simple tools such as pain drawings and the Oswestry questionnaire.
This study supports the supposition that dynamometry testing is related to factors other than muscle performance.
Received: 29 December 1998 Revised: 26 November 1999 Accepted: 8 December 1999 相似文献
73.
BACKGROUND CONTEXT: Results of subsequent surgical intervention in patients with intractable pain after lumbar spine surgery are typically worse than for initial surgery, particularly in those with predominant complaints of back pain rather than lower extremity pain. Spinal cord stimulation (SCS) has been found to yield good results in patients with primary complaints of intractable lower extremity pain. Technological advances have broadened the indications for this treatment. PURPOSE: The purpose of this study was to evaluate patient satisfaction after SCS in the treatment of patients with predominant complaints of chronic, intractable, low back pain. STUDY DESIGN/SETTING: Data were collected from retrospective chart review and patient follow-up questionnaire. Patients were treated at a spine specialty center. PATIENT SAMPLE: The study group consisted of the consecutive series of our first 41 patients who underwent SCS for predominant complaints of low back pain. The mean symptom duration was 82.9 months, and the mean age was 47.9 years (range, 28-83 years). All but three patients had previously undergone lumbar spine surgery (mean, 2.3 prior surgeries). OUTCOME MEASURES: At the time of follow-up (5.5-19 months after SCS implantation), patients completed questionnaires assessing their satisfaction with their outcome, if they would have the procedure again knowing what their outcome would be and if they would recommend SCS to someone with similar problems. In determining outcome, a negative response was assigned for patients who had the device removed. A worst-case analysis was also conducted in which a negative response was assigned for patients lost to follow-up or who failed to respond to a particular question. Data were also collected on complications and re-operations. METHODS: All trial stimulation procedures were performed under local anesthetic with the patient providing feedback concerning pain relief achieved with various lead placements and settings. If one lead did not provide acceptable relief in all the areas needed, placement of a second lead was pursued. If the patient failed to maintain acceptable pain relief (> or =50% pain relief) during a multiday trial period, the leads were removed. If adequate relief was maintained during the trial period, the receiver was implanted. RESULTS: Responses to the follow-up questionnaire indicated that 60% of patients considered themselves improved from their preoperative condition and the remaining 40% did not; 78.1% of patients would recommend SCS to someone with similar problems, 69.0% were satisfied, 75.0% would have the procedure performed again if they had known their outcome before implantation. Among the 36 patients in whom the system was implanted, it was later removed in 4 because of lack of sufficient pain relief. Other re-operations included repositioning of the leads to regain pain relief in the areas needed, replacement of a malfunctioning unit and revision of lead extension wires. CONCLUSIONS: In this retrospective study, the majority of patients were satisfied with the results of SCS and would have the procedure again knowing what their outcome would be. These results suggest that further investigation of SCS is warranted in this difficult to treat patient population presenting with predominant complaints of chronic, intractable, axial low back pain. 相似文献
74.
Sowmya Kaimal MD Mariette D’Souza MD DD Sujatha Sistla MD Subhash C. Parija MD DSC FRCPATH 《International journal of dermatology》2012,51(11):1335-1339
Background Dermatitis cruris pustulosa et atrophicans (DCPA) is a form of chronic folliculitis of the legs with a multifactorial etiopathogenesis, seen primarily in tropical countries. Staphylococcus aureus has been isolated from the pustules in earlier studies, although the organisms isolated have not been further characterized. Materials and methods Patients with DCPA, who attended the Dermatology outpatient clinic at JIPMER, Pondicherry, India, during the study period (December 2006–June 2008) were included. Pus from the lesions as well as swabs from carrier sites (nares, axillae, and gluteal fold) were cultured. Staphylococcus aureus isolates were subjected to phage typing at the National Staphylococcal Phage Typing Center, Department of Microbiology, Maulana Azad Medical College, New Delhi, India. Results Thirty‐seven patients were included in the study. Pus from the folliculitic lesions grew S. aureus in 32 (86.49%) patients. Based on the comparison of antibiotic sensitivity patterns, isolates from pus and carrier sites were found to be similar in 15 patients. Phage typing established the organism to be identical in five of these patients. Conclusions Characterization of S. aureus in DCPA shows that there is no specific phage type that is uniformly responsible for the lesions in most patients. However, in view of the unclear etiology of this condition, the pathogenicity of a staphylococcal carrier state in individual patients needs to be addressed. 相似文献
75.
Kanakapura Nanjundaswamy Shivaswamy MD DNB Tharayil Kunneth Sumathy MD MNAMS Arakali Lakshminarayana Shyamprasad MD Chandrasekharan Ranganathan MD DD 《International journal of dermatology》2009,48(7):731-733
Recessive dystrophic epidermolysis bullosa (RDEB) is a rare form of epidermolysis bullosa (EB) that presents with generalized blistering since birth. Squamous cell carcinoma (SCC) is the most common cutaneous malignancy seen in RDEB, starting from second decade onwards. We report a case of SCC complicating RDEB in a 6-year-old girl. 相似文献
76.
Obstruction of the small intestine: accuracy and role of CT in diagnosis 总被引:17,自引:0,他引:17
Maglinte DD; Gage SN; Harmon BH; Kelvin FM; Hage JP; Chua GT; Ng AC; Graffis RF; Chernish SM 《Radiology》1993,188(1):61
77.
Radiography of specimens is an essential step in confirming excision of nonpalpable breast lesions. On occasion, however, the pathologist may not identify the lesion histologically. The authors report five cases in which suspicious microcalcifications were included in the excised tissue but were not identified by the pathologist. In all five, paraffin tissue block radiography enabled identification of the specific blocks containing the microcalcifications. The correct tissue blocks were then sectioned again, and the microcalcifications were identified histopathologically. In one case, the initial diagnosis of intraductal hyperplasia was changed to intraductal carcinoma with focal invasion. When the pathologist cannot identify the calcifications on initial histopathologic sections, this technique may assist in identification of the mammographic abnormality. 相似文献
78.
Age is not as important in predisposing to infections as are the associated problems peculiar to certain age groups. Factors such as the advanced age of the patients combined with the presence of chronic disease reduce their resistance to infection. This study comprises 212 elderly patients (aged 65-98 years) who were treated with 500-1000 mg/day ciprofloxacin for 1-18 days. Despite the high incidence of associated chronic diseases, microbiology showed that infections were eradicated in 88.5%. Clinical resolution occurred in 75.5% of patients and clinical failure occurred in 6.1%. Treatment was well tolerated, with clinical side-effects reported in only seven patients. Ciprofloxacin may be considered an effective and safe antimicrobial agent for the treatment of infections in the elderly. 相似文献
79.
80.