全文获取类型
收费全文 | 2273篇 |
免费 | 110篇 |
国内免费 | 34篇 |
专业分类
耳鼻咽喉 | 53篇 |
儿科学 | 87篇 |
妇产科学 | 42篇 |
基础医学 | 214篇 |
口腔科学 | 124篇 |
临床医学 | 130篇 |
内科学 | 428篇 |
皮肤病学 | 53篇 |
神经病学 | 148篇 |
特种医学 | 118篇 |
外科学 | 571篇 |
综合类 | 31篇 |
一般理论 | 1篇 |
预防医学 | 64篇 |
眼科学 | 46篇 |
药学 | 124篇 |
中国医学 | 4篇 |
肿瘤学 | 179篇 |
出版年
2024年 | 1篇 |
2023年 | 22篇 |
2022年 | 28篇 |
2021年 | 66篇 |
2020年 | 52篇 |
2019年 | 65篇 |
2018年 | 66篇 |
2017年 | 49篇 |
2016年 | 71篇 |
2015年 | 89篇 |
2014年 | 114篇 |
2013年 | 124篇 |
2012年 | 170篇 |
2011年 | 191篇 |
2010年 | 118篇 |
2009年 | 95篇 |
2008年 | 180篇 |
2007年 | 216篇 |
2006年 | 156篇 |
2005年 | 160篇 |
2004年 | 118篇 |
2003年 | 107篇 |
2002年 | 67篇 |
2001年 | 12篇 |
2000年 | 7篇 |
1999年 | 8篇 |
1998年 | 15篇 |
1997年 | 9篇 |
1996年 | 8篇 |
1995年 | 5篇 |
1994年 | 4篇 |
1993年 | 3篇 |
1992年 | 5篇 |
1991年 | 2篇 |
1990年 | 3篇 |
1989年 | 1篇 |
1987年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1970年 | 1篇 |
1961年 | 1篇 |
排序方式: 共有2417条查询结果,搜索用时 15 毫秒
31.
32.
Harmful alcohol use encompasses a spectrum of habits, including heavy episodic drinking (HED) which increases the risk of acute alcohol-related harms. The prevalence of HED in Saint Vincent and the Grenadines (SVG) is 5.7% among the overall population aged 15 years and older and 10.2% among drinkers. Responsible Beverage Service interventions train alcohol servers to limit levels of intoxication attained by customers and decrease acute alcohol-related harms. The objectives of this study were to determine bar tenders’ and rum shopkeepers’ knowledge of and attitudes toward problem drinking and willingness to participate in server training. Researchers used convenience and purposive sampling to recruit 30 participants from Barraouile, Kingstown, and Calliaqua to participate in semi-structured interviews designed to explore study objectives. Results and conclusions were derived from grounded theory analysis. Heavy episodic drinking is common but not stigmatized. Heavy drinking is considered a “problem” if the customer attains a level of disinhibition causing drunken and disruptive or injurious behavior. Bartenders and rum shopkeepers reported intervening with visibly intoxicated patrons and encouraging cessation of continued alcohol consumption. Participants cited economic incentives, prevention of alcohol-related harms, and personal morals as motivators to prevent drunkenness. Respondents acknowledged that encouraging responsible drinking was a legitimate part of their role and were favorable to server training. However, there were mixed opinions about the intervention’s perceived efficacy given absent community-wide standards on preventing intoxication and limitations of existing alcohol policy. Given respondents’ motivation and lack of standardized alcohol server training in SVG, mandated server training can be an effective strategy when promoted as one piece of a multi-component alcohol policy. 相似文献
33.
Evaluation of Pulmonary Artery Stiffness in Patients with Obstructive Sleep Apnea Syndrome
下载免费PDF全文
![点击此处可从《Echocardiography (Mount Kisco, N.Y.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
34.
We report a case of solitary fibrous tumor of the thyroid gland in a 51‐year‐old man with pre‐existing right recurrent laryngeal nerve paralysis from a congenital tracheoesophageal fistula repair as an infant. The left thyroid lobe was enlarged and soft. Fine needle aspiration biopsy via ultrasound guidance demonstrated a hypercellular aspirate composed of spindle cells with bland nuclear morphology. Given this histomorphology and immunohistochemical profile, the diagnosis of solitary fibrous tumor was considered and confirmed following left thyroid lobectomy. Laryngoscope, 2009 相似文献
35.
Rajendra Kumar Gokhroo Kaul Anushri M.T. Tarik C. Kailash N. Rajesh K. Ashish G. Manish C. Subhash 《Indian heart journal》2021,73(2):205-210
BackgroundSacubitril/Valsartan (ARNI) has now class 1 recommendation for treatment of heart failure with reduced ejection fraction (HFrEF). It has been shown to reduce cardiovascular morbidity & mortality in Heart failure with reduced ejection fraction (HFrEF) and significant improvement in all echocardiographic parameters besides TEI index. Tei index is a marker of inflammation, myocardial cell metabolism and its contractile function has not been evaluated as a distinctive entity so we took up this study to evaluate the effects of ARNI on the LV functions using two dimensional (2D)ECHO parameters in Indian population and to assess TEI index for myocardial function.Methods256 patients with class II, III or IV HF and EF<40% were enrolled. 171(66.8%) were males and 85(33.2%) were females. Patients were evaluated at baseline, 6 and 12 months for LVEF, LV mass &,LVMPI. Drug was discontinued in 2 patients due to angioedema, in 5 patients due to acute kidney injury and in 2 patients due to hypotension. LV mass measurement done by linear echocardiographic method and Flow Doppler method used for TEI index calculation.ResultsBaseline parameters in 247 patients were mean EF = 26.33 ± 6.28%, mean LV mass = 270.84 ± 68.94 gm, mean Tei Index = 0.852 ± 0.22. ARNI use was associated with an average gradual increase in EF, from a mean baseline of 26.33 ± 6.28% to 33.88 ± 7.73%(p = 0.000001) after 1 year of treatment. There was a significant progressive reduction of 57.97 g/m2 in mean LV mass index after 1 year of treatment (p = 0.000001).TEI index showed significant reduction from baseline mean 0.85 ± 0.22 to 0.70 ± 0.12(p = 0.000001)after 1 year of treatment.ConclusionUse of ARNI as additive adjunct to standard care of treatment resulted in significant progressive decline in LV mass and increase in TEI index. 相似文献
36.
37.
Mediastinal ectopic thyroid diagnosed by endobronchial ultrasound‐guided transbronchial needle aspiration: Report of three cases
下载免费PDF全文
![点击此处可从《Journal of clinical ultrasound : JCU》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Ayperi Ozturk MD Tugba Cicek MD Zafer Aktas MD Funda Demirag MD Aydin Yilmaz MD 《Journal of clinical ultrasound : JCU》2018,46(4):299-301
An ectopic thyroid gland results from the abnormal migration of the thyroid in the course of its development. Primary ectopic mediastinal thyroid is very rare and occurs in less than 1% of all goiters that can be surgically excised. Ectopic thyroid tissue has a characteristic sonographic appearance as smooth‐bordered, homogeneous, hypoechoic tissue with fine specular echoes. We report 3 cases of mediastinal ectopic thyroid diagnosed by endobronchial ultrasound‐guided transbrochial needle aspiration biopsy. 相似文献
38.
Yesim Eyler Mustafa Sever Ali Turgut Necmiye Yalcin Nur Zafer Aslı Suner Ersin Aksay Murat Yesilaras 《The American journal of emergency medicine》2018,36(3):425-429
Background
The aim of this study was to evaluate the sensitivity and specificity of physical examination findings and functional tests in adult acute wrist trauma patients who presented to the emergency department (ED) and to create a reliable and practical clinical decision rule for determining the necessity of radiography in wrist trauma.Methods
This prospective observational study was conducted in a tertiary ED. Each patient was checked for 18 physical examination findings and functional tests. Patients with suspected fracture were enrolled consecutively. Antero-posterior and lateral wrist views were performed for each patient. All radiographical studies were interpreted by an orthopedic surgeon. The prevalence, sensitivity and specificity, negative and positive predictive values of each finding were calculated. A modeling for predicting fractures was created using computer.Results
207 patients were evaluated and 69 patients (33.3%) had fractures. The most common encounterd fracture site was distal radius (29.5%). The most sensitive examination finding was pain in dorsiflexion (95.7%) and the most specific finding was ecchymosis (97.8%). Wrist edema, deformity and pain aggravated by pronation were found to be strong predictors of fracture. The area under the receiver operating characteristic curve at internal validation for a prediction model based on these three predictors was 0.88 (95% CI: 0.83-0,93). The overall sensitivity and specificity of this model were 94% (95% CI: 85-98%) and 51% (95% CI 43-60%) respectively. According to the model created in this study, 34% of acute blunt wrist trauma patients do not require any X-ray imaging.Conclusions
This triple modeling may be used as an effective decision rule for predicting all wrist fractures in the ED and in the disaster setting. 相似文献39.
40.
Caselli A Hanane T Jane B Carter S Khaodhiar L Veves A 《Journal of diabetes and its complications》2003,17(4):205-210
OBJECTIVE: To evaluate the vasodilation induced by topical application of methyl nicotinate (MN) and to compare it with the vasodilatory response to acetylcholine (ACh) and sodium nitroprusside (SNP) in healthy subjects and diabetic neuropathic patients. RESEARCH DESIGN AND METHODS: Ten diabetic patients with peripheral neuropathy (DN) and 10 age- and sex-matched healthy control subjects (C) were enrolled. The vasodilatory response to topical application of 1% MN and a placebo emulsion at the forearm and dorsum of the foot skin at 5, 15, 30, 60 and 120 min was measured using Laser Doppler Perfusion Imaging. The vasodilatory response to iontophoresis of 1% ACh and 1% SNP solutions was also evaluated. RESULTS: The maximal vasodilatory response to ACh, SNP and MN was similar at the forearm and foot level in the diabetic patients. In the control group, the responses to MN, ACh and SNP were similar on the forearm but in the foot, the MN vasodilatory response was higher when compared to the ACh and SNP responses. MN-related vasodilation was present 5 min after the application, reached its peak at 15-30 min and declined to pre-application levels 120 min afterward. CONCLUSIONS: Topical application of MN at the forearm and foot levels of diabetic neuropathic patients results in skin vasodilation that is comparable to the maximal vasodilation that can be induced by iontophoresis of ACh or SNP and lasts for less than 2 h. Further studies will be required to explore the potential of MN to increase blood flow and to prevent diabetic foot problems in clinical practice. 相似文献