全文获取类型
收费全文 | 26609篇 |
免费 | 1300篇 |
国内免费 | 85篇 |
专业分类
耳鼻咽喉 | 321篇 |
儿科学 | 680篇 |
妇产科学 | 638篇 |
基础医学 | 3438篇 |
口腔科学 | 1637篇 |
临床医学 | 2122篇 |
内科学 | 6454篇 |
皮肤病学 | 530篇 |
神经病学 | 1969篇 |
特种医学 | 532篇 |
外科学 | 3081篇 |
综合类 | 132篇 |
一般理论 | 13篇 |
预防医学 | 3089篇 |
眼科学 | 392篇 |
药学 | 1788篇 |
中国医学 | 150篇 |
肿瘤学 | 1028篇 |
出版年
2023年 | 235篇 |
2022年 | 153篇 |
2021年 | 562篇 |
2020年 | 346篇 |
2019年 | 610篇 |
2018年 | 1086篇 |
2017年 | 652篇 |
2016年 | 669篇 |
2015年 | 816篇 |
2014年 | 861篇 |
2013年 | 1167篇 |
2012年 | 2133篇 |
2011年 | 2371篇 |
2010年 | 1078篇 |
2009年 | 733篇 |
2008年 | 1815篇 |
2007年 | 1905篇 |
2006年 | 1704篇 |
2005年 | 1640篇 |
2004年 | 1427篇 |
2003年 | 1325篇 |
2002年 | 1215篇 |
2001年 | 480篇 |
2000年 | 547篇 |
1999年 | 392篇 |
1998年 | 98篇 |
1997年 | 49篇 |
1996年 | 48篇 |
1995年 | 46篇 |
1994年 | 29篇 |
1993年 | 37篇 |
1992年 | 239篇 |
1991年 | 168篇 |
1990年 | 146篇 |
1989年 | 124篇 |
1988年 | 113篇 |
1987年 | 108篇 |
1986年 | 101篇 |
1985年 | 90篇 |
1984年 | 61篇 |
1983年 | 58篇 |
1979年 | 35篇 |
1975年 | 40篇 |
1974年 | 50篇 |
1973年 | 30篇 |
1971年 | 37篇 |
1970年 | 38篇 |
1969年 | 36篇 |
1968年 | 41篇 |
1967年 | 28篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
41.
Roberto Rivera-Luna Marta Zapata-Tarrés Aurora Medina-Sansón Enrique López-Aguilar Ana Niembro-Zúñiga J. Amador Zarco Alfonso Marhx-Bracho Fernando Rueda-Franco Leticia Bornstein-Quevedo 《Child's nervous system》2007,23(5):543-547
Objective The purpose of this study is to analyze clinical aspects and disease-free survival (DFS) in children less than 3 years of
age diagnosed with low-grade astrocytoma.
Methods In a period of 24 years (1980–2004), a total of 43 (5.4%) children were registered with these characteristics. Twenty-three
patients had pilocytic astrocytoma, 18 diffused, and 2 mixed. Thirty-one (72.1%) children had incomplete surgical tumor resection
and 12 (27.9%) had a complete tumor resection. Twelve (27.9%) patients had cranial radiotherapy and 17 (39.5%) received chemotherapy.
Overall survival was recorded in 23 (53%). DFS was 50% at 250 months of follow-up for the whole group. DFS for the supratentorial
group was 60% at 250 months, whereas, for the infratentorial, it was 22% at 120 months (p = 0.008).
Conclusion The only favorable prognostic pattern was the supratentorial presentation. Radiotherapy and chemotherapy did not alter the
outcome. 相似文献
42.
Eulogio Valentín Jesús Zueco Almudena Nieto Rafael Sentandreu Lucas del Castillo Agudo 《Current genetics》1992,21(4-5):291-293
Summary The RPS5 gene has been characterised through its ability to reduce invertase production by the SUC5 gene. In this paper we show that RPS5 acts by maintaining low levels of SUC5 mRNA. We also show that RPS5 acts on the SUC1 and SUC4 genes but not on SUC2 and SUC3, which are members of the SUC family. RPS5 also shows a pleiotropic effect on the amount of mitochondrial cytochromes. 相似文献
43.
The purpose of this study was to investigate the disposition and the nephrotoxicity of 3-amino-1-hydroxypropylidene-1, 1-bisphosphonate (APD-pamidronate) in order to elucidate the mechanism of the non-linearity of the renal elimination of this drug. The fate of APD labelled with [14C]APD was studied in mice and rats for a range of doses (0.5-40 mg/kg) and indicators of renal function were monitored. In both species, the percentage of dose excreted during the first 24-h after treatment fell dramatically as a function of the dose. However, the renal burden of APD rose linearly for doses of APD below 10 mg/kg and increased non-linearly over this threshold. In contrast the concentration of APD in both bone and liver, which together account for a large proportion of the dose, appeared to increase proportionally with dose. There was no evidence, therefore, that the non-linear renal elimination of APD was due to an increased uptake of APD by tissues. Conversely, the significant fall in the renal excretion of APD was paralleled by a striking loss in body weight, and for high doses, by a fall in the creatinine clearance. An increased enzymuria suggested the loss of brush border membranes and the release of lysosomal contents by proximal tubular cells. Morphological studies confirmed this and revealed a focal proximal tubular necrosis 6 days post dosing. We conclude that the nephrotoxicity of APD accounts for the non-linear renal elimination of this drug. 相似文献
44.
V Rafnsson S G Jóhannesdóttir H Oddsson H Benediktsson H Tulinius G Magnússon 《Scandinavian journal of work, environment & health》1988,14(3):197-200
A retrospective cohort study of mortality and cancer morbidity was carried out among 295 marine engineers and 182 machinists with special regard to cancer of the lung. The cohort was defined as all graduates from engineering and machinists school in Iceland during 1936-1955. During vocational training, as well as in their professional lives, marine engineers and machinists are exposed to asbestos, different kinds of mineral oils, and exhaust gases with marked individual variation as regards mode and magnitude of exposure. For deaths occurring between 1951 and 1982 information was obtained from the Statistical Bureau of Iceland. Significantly increased standardized mortality ratios were determined for cancer of the trachea, bronchus, and lung for the entire cohort. Record linkage with the Cancer Register revealed 36 cancers in the period 1955-1982. No statistically significant excess was found for the overall cancer incidence or for the incidence of cancer at any particular site. A special survey of smoking status showed that cigarette smoking was not as common among the subjects of the cohort as among the general male population in Reykjavik. These results support the suggestion that the increased mortality of lung cancer in the study group had a causal relationship to occupational exposure, particularly to asbestos exposure. 相似文献
45.
A López Granados M Anguita Sánchez M D Mesa Rubio M Franco Zapata R Vivancos Delgado G Bueno Ferrer J Suárez de Lezo F Vallés Belsúe 《Revista espa?ola de cardiología》1991,44(3):210-212
Almost 90% of primary acute pericarditis are idiopathic. Between specifics forms, a very low percentage of cases are due to chronic rheumatic diseases. A case of adult Still's disease (juvenile chronic rheumatoid arthritis) with acute pericarditis being the first clinical manifestation (besides fever and general syndrome) is presented. Therapy with oral prednisone was rapidly effective, and pericardial effusion resolved after 3 weeks of treatment, as echocardiography showed. 相似文献
46.
The advantages of fat filling for hand rejuvenescence are discussed. Seventy-two patients treated by this method are presented, including their follow-up, complication rate, and details of combined operations. Preference is given to local anesthesia when no other major surgeries are associated with the method. A highly satisfactory rate was obtained (98.62%) with a low complication rate (4.15%). 相似文献
47.
José I. Bilbao Manuel Ruza Jesús M. Longo Francisco Mansilla Antonio Picardi Vanessa de Villa Fernando Pardo Jesús Sola Jorge Quiroga 《Cardiovascular and interventional radiology》1994,17(4):210-213
Posttransplant lymphoproliferative disorders are infrequent tumors related to chronic immunosuppressive therapy. We present a liver transplant recipient who developed such a tumor in the porta hepatis that provoked obstruction of the entire portal triad. Treatment consisted of systemic chemotherapy, percutaneous dilatation, and placement of Wallstent endoprostheses across both biliary and portal vein stenoses. The patient died 3 weeks later of pneumonia and sepsis. At necropsy, the tumor was completely necrosed and the prostheses in both the common bile duct and the portal vein were patent. 相似文献
48.
Primary pregnancy in the liver. A case report 总被引:1,自引:0,他引:1
A de A Barbosa Júnior L A de Freitas M A Mota 《Pathology, research and practice》1991,187(2-3):329-31; discussion 332-3
A case of intra-hepatic pregnancy is reported. The patient was 32 years old and presented with an acute intra-abdominal hemorrhage. At surgery a spongy 3 x 2 x 1.5 cm mass was removed from the right liver lobe. Microscopically, well developed chorionic villi appeared invading the liver tissue. The patient had a relatively uneventful recovery. 相似文献
49.
50.
F Arreola R Paniagua J Herrera S Díaz-Bensussen L Mondragón J A Bermúdez E Pérez Pastén S Villalpando 《Archives of andrology》1986,16(2):151-154
Plasma zinc and pituitary and testicular hormone concentrations were measured in two groups of male adolescents. One group comprised insulin-dependent diabetes mellitus patients, aged 14-19 years; the other, as control, included 12 healthy youngsters aged 13-19 years. Plasma concentration of zinc, prolactin, testosterone, and dihydrotestosterone were lower in diabetics than in controls, whereas the ratios of androstenedione and androstenedione to testosterone + dihydrotestosterone were higher. Plasma FSH and LH were normal. These results suggest a diminished conversion of androstenedione to testosterone and relate zinc with the 17-beta-hydroxysteroid dehydrogenase enzyme activity. 相似文献