全文获取类型
收费全文 | 562篇 |
免费 | 37篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 18篇 |
妇产科学 | 6篇 |
基础医学 | 49篇 |
口腔科学 | 7篇 |
临床医学 | 62篇 |
内科学 | 127篇 |
皮肤病学 | 10篇 |
神经病学 | 7篇 |
特种医学 | 78篇 |
外科学 | 147篇 |
综合类 | 11篇 |
预防医学 | 20篇 |
眼科学 | 2篇 |
药学 | 41篇 |
肿瘤学 | 22篇 |
出版年
2020年 | 5篇 |
2019年 | 3篇 |
2018年 | 6篇 |
2017年 | 8篇 |
2016年 | 11篇 |
2015年 | 9篇 |
2014年 | 12篇 |
2013年 | 12篇 |
2012年 | 15篇 |
2011年 | 17篇 |
2010年 | 13篇 |
2009年 | 11篇 |
2008年 | 11篇 |
2007年 | 24篇 |
2006年 | 11篇 |
2005年 | 22篇 |
2004年 | 19篇 |
2003年 | 15篇 |
2002年 | 12篇 |
2001年 | 14篇 |
2000年 | 12篇 |
1999年 | 10篇 |
1998年 | 17篇 |
1997年 | 23篇 |
1996年 | 26篇 |
1995年 | 23篇 |
1994年 | 23篇 |
1993年 | 16篇 |
1992年 | 13篇 |
1991年 | 18篇 |
1990年 | 19篇 |
1989年 | 27篇 |
1988年 | 14篇 |
1987年 | 14篇 |
1986年 | 8篇 |
1985年 | 8篇 |
1984年 | 6篇 |
1983年 | 5篇 |
1982年 | 8篇 |
1981年 | 6篇 |
1979年 | 7篇 |
1978年 | 6篇 |
1977年 | 5篇 |
1976年 | 5篇 |
1975年 | 10篇 |
1974年 | 3篇 |
1973年 | 6篇 |
1970年 | 3篇 |
1968年 | 3篇 |
1967年 | 3篇 |
排序方式: 共有615条查询结果,搜索用时 15 毫秒
21.
22.
Nicolas von Landenberg Atiqullah Aziz Friedrich C. von Rundstedt Jakub Dobruch Luis A. Kluth Andrea Necchi Aidan Noon Michael Rink Kees Hendricksen Karel P.J. Decaestecker Roland Seiler Cédric Poyet Harun Fajkovic Shahrokh F. Shariat Evanguelos. Xylinas Florian Roghmann 《Urologic oncology》2018,36(5):238.e19-238.e27
Objective
To determine conditional recurrence-free survival (RFS) and progression-free survival (PFS) and improve decision-making toward surveillance protocols and scheduling. Furthermore, evaluating the evolution of predictors for disease recurrence over time, because TaG1 non–muscle-invasive bladder cancer harbors a risk of disease recurrence and progression.Material and methods
The retrospective multicenter design study includes 1,245 TaG1 bladder cancer patients with median follow-up of 62.7 (interquartile range: 34.3–91.1) months. Conditional RFS and PFS estimates were calculated using the Kaplan-Meier method. Multivariable Cox regression model was calculated proportional for the prediction of recurrence and progression (covariables: age, tumor size, multiple tumors, prior recurrence, and immediate postoperative instillation of chemotherapy).Results
After 3 months without event, the conditional RFS and PFS (to ≥pT2) rates for 5 additional years without event were 57.5% and 93.4%, respectively. Given a 1-, 2-, 3-, and 5-year survival, the conditional RFS rates for 5 additional years without event improved by +9.8 (67.3%), +5.2 (72.5%), +6.5 (79.0%), +2.0 (81.0%), and +1.0% (82.0%), respectively. In contrast, the 5-year conditional PFS rates were more or less stable with 94.3% after 1 year to 94.1% after 5 years. Multivariable analyses showed decreasing impact of risk parameters on RFS estimates over time. Based on these findings, we suggest a risk stratification to individualize follow-up for intermediate risk TaG1. Main limitation was the retrospective design.Conclusions
Conditional-survival analyses demonstrates that the patient risk profile changes over time. RFS rates rise with increasing survival whereas PFS rates were stable. The impact of prognostic features decreases over time. Our findings can be used for patient counseling and planning of personalized follow-up. 相似文献23.
24.
25.
26.
In situ preservation of cadaver kidneys for transplantation: laboratory observations and clinical application. 总被引:1,自引:0,他引:1
下载免费PDF全文
![点击此处可从《Annals of surgery》网站下载免费的PDF全文](/ch/ext_images/free.gif)
R Garcia-Rinaldi E A Lefrak W W Defore L Feldman G P Noon J A Jachimczyk M E DeBakey 《Annals of surgery》1975,182(5):576-584
Many kidneys obtained from cadaver donors undergoing sudden cardiac arrest cannot be transplanted due to the long periods of warm ischemia from the moment of arrest to nephrectomy. A double-ballon-triple-lumen catheter for the rapid in situ preservation of cadaver kidneys has been designed. Used in combination with equipment routinely found in any hospital, it can cool human kidneys in situ to 10-15 C and maintain this temperature until nephrectomy can be performed. Kidenys preserved with this catheter have functioned after transplantation into suitable recipients. This report describes the design and laboratory evaluation of this new device, its clinical effectiveness and technique of insertion. 相似文献
27.
28.
Surgical management of tracheal trauma 总被引:1,自引:0,他引:1
29.
30.
Skrabal CA Thompson LO Southard RE Joyce DL Noon GP Loebe M Youker KA 《The Journal of surgical research》2004,118(1):66-70
INTRODUCTION: Previously, we reported an increase in interstitial collagen and total mast-cell numbers in heart failure versus normal myocardium. A secondary increase, primarily in chymase-negative mast cells, occurred following LVAD support compared to matched pre-LVAD tissue samples and was associated with a decrease in interstitial collagen and bFGF. To further elucidate the changes in interstitial collagen, we investigated the direct interaction between mast cells, isolated from failing myocardium with or without previous LVAD support, and human fibroblasts in a coculture model. Additionally, the expression of HSP-47, the pro-collagen-specific chaperone protein, was determined in the particular myocardium. MATERIALS AND METHODS: Myocardial tissue was obtained from 10 patients with end-stage dilated cardiomyopathy (DCM) at the time of transplantation. Five patients were transplanted following LVAD support, five patients without previous LVAD support. Mast cells were isolated according to a standard protocol, including collagenase digestion and cell separation. The isolated mast cells were co-cultured with human fibroblasts for 12 h, with or without stimulation of degranulation, and protein synthesis was measured by [(3)H]-proline incorporation. HSP-47 immunostaining was performed in the different myocardial samples and the positive cells were quantified. RESULTS: Stimulated mast cells isolated from DCM tissue (without previous LVAD support) caused a 92% increase in [(3)H]-proline incorporation and consequently in protein production in fibroblasts compared to mast-cell free culture (P < 0.01), while conversely stimulated mast cells isolated from LVAD supported myocardium decreased the [(3)H]-proline incorporation by 63% (P < 0.01) below baseline. Nonstimulated mast cells did not significantly alter the protein production over baseline. There was also a significant increase in the number of HSP-47-positive cells in DCM myocardium compared to normal (P < 0.01) and there was a shift toward normal after LVAD support (P < 0.01). CONCLUSION: We demonstrate that fibroblast protein production in vitro is significantly altered by mast cells and that the direction of change is dependent on whether myocardium was supported by LVAD. We suggest that under long-term LVAD support there is a phenotypic alteration in myocardial mast cells, which leads to a change in concentration and/or composition of mediators, capable of re-remodeling the myocardial matrix. 相似文献