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991.
Tomohide Yamada MD Ryuichi Kamata Kotomi Ishinohachi Nobuhiro Shojima MD Sophia Ananiadou PhD Hisashi Nom PhD Toshimasa Yamauchi MD Takashi Kadowaki MD 《Diabetes, obesity & metabolism》2018,20(7):1787-1792
Biosimilar insulins have expanded the treatment options for diabetes. We compared the clinical efficacy and safety of biosimilar insulins with those of originator insulins by conducting a meta‐analysis. A random‐effects meta‐analysis was performed on randomized controlled trials comparing biosimilar and originator insulins in adults with diabetes. Studies were obtained by searching electronic databases up to December 2017. Ten trials, in a total of 4935 patients, were assessed (2 trials each on LY2963016, MK‐1293, Mylan's insulin glargine and SAR342434, and 1 trial each on FFP‐112 and Basalog). The meta‐analysis found no differences between long‐acting biosimilar and originator insulins with regard to reduction in glycated haemoglobin at 24 weeks (0.04%, 95% confidence interval [CI] –0.01, 0.08; P for efficacy = .14, I2 = 0%) or at 52 weeks (0.03%, 95% CI –0.04, 0.1), or reduction in fasting plasma glucose (0.08 mmol/L, 95% CI 0.36, 0.53), hypoglycaemia (odds ratio 0.99, 95% CI 0.96, 1.03), mortality, injection site reactions, insulin antibodies and allergic reactions. Analyses stratified by type of diabetes and prior insulin use yielded similar findings. Similarly, no significant differences were found between short‐acting biosimilar and originator insulins. In summary, our meta‐analysis showed no significant differences in clinical efficacy and safety, including immune reactions, between biosimilar and originator insulins. Biosimilar insulins can increase access to modern insulin therapy and reduce medical costs. 相似文献
992.
Pancreatic fat content assessed by 1H magnetic resonance spectroscopy is correlated with insulin resistance,but not with insulin secretion,in Japanese individuals with normal glucose tolerance 下载免费PDF全文
993.
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995.
Yuji Nakamura Yasuko Togawa Yusuke Okuno Hideki Muramatsu Kazuhiko Nakabayashi Yoko Kuroki Daisuke Ieda Ikumi Hori Yutaka Negishi Takao Togawa Ayako Hattori Seiji Kojima Shinji Saitoh 《Brain & development》2018,40(2):134-139
Mutations in SZT2 were first reported in 2013 as a cause of early-onset epileptic encephalopathy. Because only five reports have been published to date, the clinical features associated with SZT2 remain unclear. We herein report an additional patient with biallelic mutations in SZT2. The proband, a four-year-old girl, showed developmental delay and seizures from two years of age. Her seizures were not intractable and readily controlled by valproate. She showed mildly dysmorphic facies with macrocephaly, high forehead, and hypertelorism, and also had pectus carinatum. An EEG showed epileptic discharges which rarely occurred. A brain MRI revealed a short and thick corpus callosum. Whole-exome sequencing detected compound heterozygous biallelic mutations (c.8596dup (p.Tyr2866Leufs142) and c.2930-17_2930-3delinsCTCGTG) in SZT2, both of which were novel and predicted to be truncating. This case suggested a broad phenotypic spectrum arises from SZT2 mutations, forming a continuum from epileptic encephalopathy and severe developmental delay to mild intellectual disability without epilepsy. The characteristic thick and short corpus callosum observed in 7/8 cases with epilepsy, including the proband, but not in three non-syndromic cases, appears to be specific, and thus useful for indicating the possibility of SZT2 mutations. This feature has the potential to make loss of SZT2 a clinically discernible disorder despite a wide clinical spectrum. 相似文献
996.
Yoshikazu Takaesu Koichiro Watanabe Shusuke Numata Masaaki Iwata Noriko Kudo Satoru Oishi Takeya Takizawa Kiyotaka Nemoto Yuka Yasuda Hiromi Tagata Takashi Tsuboi Naohisa Tsujino Naoki Hashimoto Yuki Matsui Hikaru Hori Hidenaga Yamamori Nobuhiro Sugiyama Taro Suwa Taishiro Kishimoto Akitoyo Hishimoto Masahide Usami Ryuji Furihata Kunihiro Iwamoto Hiroshige Fujishiro Toshinori Nakamura Kentaro Mizuno Takahiko Inagaki Eiichi Katsumoto Hiroaki Tomita Kazutaka Ohi Hiroyuki Muraoka Kiyokazu Atake Hitoshi Iida Tatsuya Nagasawa Junichi Fujita Satoshi Yamamura Toshiaki Onitsuka Atsunobu Murata Yoichiro Takayanagi Hokuto Noda Yukiko Matsumura Kenji Takezawa Jun‐ichi Iga Kayo Ichihashi Kazuyoshi Ogasawara Hisashi Yamada Ken Inada Ryota Hashimoto 《Psychiatry and clinical neurosciences》2019,73(10):642-648
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998.
Chen Liang Kazuhiro Takahashi Masanao Kurata Shingo Sakashita Tatsuya Oda Nobuhiro Ohkohchi 《World journal of gastroenterology : WJG》2019,25(18):2264-2270
BACKGROUND Polycystic liver disease(PCLD) with a large cystic volume deteriorates the quality of life of patients through substantial effects on the adjacent organs,recurrent cyst infections, cyst rupture, and hemorrhage. Surgical or radiological intervention is usually needed to alleviate these symptoms. We report a rare case of the cystic metastasis of renal cell carcinoma(RCC), which was misdiagnosed as PCLD, as a result of the clinical and radiological similarity between these disorders.CASE SUMMARY A 74-year-old female who had undergone nephrectomy for papillary-type RCC(PRCC) was suffering from abdominal pain and the recurrent intracystic hemorrhage of multiple cysts in the liver. Imaging studies and aspiration cytology of the cysts showed no evidence of malignancy. With a diagnosis of autosomal dominant polycystic liver disease, the patient received hepatectomy for the purpose of mass reduction and infectious cyst removal. Surgery was performed without complications, and the patient was discharged on postoperative day 14. Postoperatively, the pathology revealed a diagnosis of recurrent PRCC with cystic formation.CONCLUSION This case demonstrates the importance of excluding the cystic metastasis of a cancer when liver cysts are observed. 相似文献
999.
Momoko Nakayama Yuko Uchida Akihiro Shibata Yoshifumi Kobayashi Junki Mine Nobuhiro Takemae Ryota Tsunekuni Taichiro Tanikawa Rieko Harada Hiroyuki Osaka Takehiko Saito 《Transboundary and Emerging Diseases》2019,66(6):2342-2352
The first human case of zoonotic H7N9 avian influenza virus (AIV) infection was reported in March 2013 in China. This virus continues to circulate in poultry in China while mutating to highly pathogenic AIVs (HPAIVs). Through monitoring at airports in Japan, a novel H7N3 reassortant of the zoonotic H7N9 HPAIVs, A/duck/Japan/AQ‐HE30‐1/2018 (HE30‐1), was detected in a poultry meat product illegally brought by a passenger from China into Japan. We analysed the genetic, pathogenic and antigenic characteristics of HE30‐1 by comparing it with previous zoonotic H7N9 AIVs and their reassortants. Phylogenetic analysis of the entire HE30‐1 genomic sequence revealed that it comprised at least three different sources; the HA (H7), PB1, PA, NP, M and NS segments of HE30‐1 were directly derived from H7N9 AIVs, whereas the NA (N3) and PB2 segments of HE30‐1 were unrelated to zoonotic H7N9. Experimental infection revealed that HE30‐1 was lethal in chickens but not in domestic or mallard ducks. HE30‐1 was shed from and replicated in domestic and mallard ducks and chickens, whereas previous zoonotic H7N9 AIVs have not adapted well to ducks. This finding suggests the possibility that HE30‐1 may disseminate to remote area by wild bird migration once it establishes in wild bird population. A haemagglutination‐inhibition assay indicated that antigenic drift has occurred among the reassortants of zoonotic H7N9 AIVs; HE30‐1 showed similar antigenicity to some of those H7N9 AIVs, suggesting it might be prevented by the H5/H7 inactivated vaccine that was introduced in China in 2017. Our study reports the emergence of a new reassortant of zoonotic H7N9 AIVs with novel viral characteristics and warns of the challenge we still face to control the zoonotic H7N9 AIVs and their reassortants. 相似文献
1000.
Ryota Tsunekuni Kasumi Sudo Phuong Thanh Nguyen Bach Duc Luu Thai Duy Phuong Tran Minh Tan Tung Nguyen Junki Mine Momoko Nakayama Taichiro Tanikawa Kirill Sharshov Nobuhiro Takemae Takehiko Saito 《Transboundary and Emerging Diseases》2019,66(6):2209-2217
Since 2013, H5N6 highly pathogenic avian influenza viruses (HPAIVs) have been responsible for outbreaks in poultry and wild birds around Asia. H5N6 HPAIV is also a public concern due to sporadic human infections being reported in China. In the current study, we isolated an H5N6 HPAIV strain (A/Muscovy duck/Long An/AI470/2018; AI470) from an outbreak at a Muscovy duck farm in Long An Province in Southern Vietnam in July 2018 and genetically characterized it. Basic Local Alignment Search Tool (BLAST) analysis revealed that the eight genomic segments of AI470 were most closely related (99.6%–99.9%) to A/common gull/Saratov/1676/2018 (H5N6), which was isolated in October 2018 in Russia. Furthermore, AI470 also shared 99.4%–99.9% homology with A/Guangxi/32797/2018, an H5N6 HPAIV strain that infected humans in China in 2018. Phylogenetic analyses of the entire genome showed that AI470 was directly derived from H5N6 HPAIVs that were in South China from 2015 to 2018 and clustered with four H5N6 HPAIV strains of human origin in South China from 2017 to 2018. This indicated that AI470 was introduced into Vietnam from China. In addition, molecular characteristics related to mammalian adaptation among the recent human H5N6 HPAIV viruses, except PB2 E627K, were shared by AI470. These findings are cause for concern since H5N6 HPAIV strains that possess a risk of human infection have crossed the Chinese border. 相似文献