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Poddar N Avezbakiyev B He Z Jiang M Gohari A Wang JC 《Journal of gastrointestinal cancer》2012,43(3):486-489
Introduction
Portal vein thrombosis is frequently associated with hepatocellular carcinoma (HCC). Tumor invasion into the portal vein by direct venous extension or metastasis occurs in up to 70% of HCC patients (Cedrone et al., Liver 16:94–8, 1996). However, presentation as an isolated malignant portal vein thrombosis without any evidence of obvious hepatoma-like lesions in the liver by imaging studies is extremely uncommon. We present an unusual case of HCC presenting as a malignant portal vein thrombus, proven on biopsy of the thrombus without any evidence of primary liver lesion. This, to our knowledge, is the first case of HCC presenting as an incidental isolated malignant portal vein thrombosis. The importance of doing delayed enhancement imaging studies to rule out malignant portal vein thrombosis is emphasized. 相似文献93.
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Dmytro Starenki Nishant K. SinghDavin R. Jensen Francis C. PetersonJong-In Park 《Cancer letters》2013
Medullary thyroid carcinoma (MTC) is a neoplasm of the endocrine system, which originates from parafollicular C-cells of the thyroid gland. For MTC therapy, the Food and Drug Administration recently approved vandetanib and cabozantinib, multi-kinase inhibitors targeting RET and other tyrosine kinase receptors of vascular endothelial growth factor, epidermal growth factor, or hepatocyte growth factor. Nevertheless, not all patients with the progressive MTC respond to these drugs, requiring the development of additional therapeutic modalities that have distinct activity. Previously, we reported that expression of activated Ras or Raf in the human MTC cell lines, TT and MZ-CRC-1, can induce growth arrest and RET downregulation via a leukemia inhibitory factor (LIF)-mediated autocrine/paracrine loop. In this study, we aimed to evaluate bacterially-produced recombinant human LIF for its efficacy to suppress human MTC xenografts in mice. Here, we report that, consistent with its effects in vitro, locally or systemically administered recombinant LIF effectively suppressed growth of TT and MZ-CRC-1 xenografts in mice. Further, as predicted from its effects in TT and MZ-CRC-1 cell cultures in vitro, recombinant LIF activated the JAK/STAT pathway and downregulated RET and E2F1 expression in tumors in mice. These results suggest that LIF is a potent cytostatic agent for MTC cells, which regulates unique mechanisms that are not targeted by currently available therapeutic agents. 相似文献
97.
This case-series analyzed the outcome of live donor liver transplantation (LT) performed in children <7.5kg from January 2008
to June 2009 at our center. Five patients (3 males, 2 females, mean age, 8.2 ±.4 months; mean weight 6.8 ± 0.4 kg) underwent
LT. The indications of LT included biliary atresia (3) and idiopathic neonatal hepatitis (2). Postoperative complications
included acute rejection (1), portal venous thrombosis (1), bile leak (1), severe hypertension (1) and bacterial sepsis (4).
There were no donor related complications. The median follow-up duration is 11 months with patient and graft survival rates
of 100% each, respectively. 相似文献
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Uday Yanamandra Nishant Pathak Nardeep Naithani Naveen Grover Velu Nair 《Journal of infection and chemotherapy》2012,18(1):109-111
Tuberculosis affects almost every organ of the body, and the breast is no exception. However, tuberculosis of the breast is
rare, and the varied presentation requires a high index of suspicion, especially in middle-aged women for whom a clinical
diagnosis of malignancy is likely to be made. We report two cases of primary tuberculosis of breast with different manifestations.
One case presented as tuberculous mastitis and the other presented with a lump masquerading as breast carcinoma. The diagnosis
in both cases was based on demonstration of acid-fast bacilli on histopathological examination. Resolution was complete with
antitubercular therapy, and major surgical intervention was not necessary. 相似文献
100.