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Kumari Preeti Swami Muddineti Omkara Lakhani Prit Manish Nadipalli Sravan Kumar Myneni Srividya Ghosh Balaram Biswas Swati 《Pharmaceutical research》2016,33(7):1795-1795
Pharmaceutical Research - 相似文献
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Effectiveness and tolerability of simeprevir and sofosbuvir in nontransplant and post‐liver transplant patients with hepatitis C genotype 1 下载免费PDF全文
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Prospective evaluation of patient‐reported quality of life outcomes after external beam radiation treatment for prostate cancer in Victoria: A cohort study by the Victorian Prostate Cancer Registry 下载免费PDF全文
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Shechter M Shechter A Hod H Fefer P Shenkman B Koren-Morag N Feinberg MS Harats D Ami Sela B Savion N Varon D Matetzky S 《Platelets》2012,23(3):202-210
Platelet activation occurs in an endothelium-dependent flow-mediated dilation (FMD) impairment environment. The aim of this study was to explore the association between platelet reactivity and brachial artery FMD in individuals without established cardiovascular disease (controls) and acute myocardial infarction (AMI) patients. We prospectively assessed brachial artery FMD in 151 consecutive subjects, 104 (69%) controls, and 47 (31%) AMI patients; 115 (76%) men, mean age 53?±?11 years. Following overnight fasting and discontinuation of all medications for?≥?12?h, percent change in brachial artery FMD (%FMD) and endothelium-independent, nitroglycerin-mediated vasodilation (%NTG) were assessed. Platelet aggregation was assessed by conventional aggregometry, and platelet adhesion and aggregation under flow conditions by cone-and-plate(let) technology (Impact-R). Smoking, diabetes, and hypertension were more common in AMI compared to control subjects (p?0.01 for all). Furthermore, aspirin, clopidogrel, beta-blockers, angiotensin-converting enzyme inhibitors, and statin administration were more common in AMI compared to controls (p?0.01 for all). %FMD but not %NTG was significantly lower in AMI patients compared to controls (10.2?±?4.2% vs. 15.4?±?4.4%; p?0.001 and 17.2?±?3.9% vs. 18.0?±?3.7%, p?=?0.803, respectively). %FMD was significantly and inversely associated with all platelet functions tests (p?0.001) in all study participants. In a multivariate logistic regression (unadjusted and adjusted for age, gender, smoking status, diabetes mellitus, hypertension, hypercholesterolemia, overweight, family history, and concomitant medications), %FMD remained the best predictor of platelet function, irrespective of group allocation (AMI patients or controls). In conclusion, FMD is inversely correlated to platelet reactivity in both controls and AMI patients. 相似文献
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Claudia Miranda-Castillo Bob Woods Kumari Galboda Sabu Oomman Charles Olojugba Martin Orrell 《Health and quality of life outcomes》2010,8(1):132
Background
There is lack of evidence about the unmet needs of people with dementia (PWD) living at home and the predictors of high levels of unmet needs. The main aim of this study was to identify the relationship between unmet needs, social networks and quality of life of PWD living at home. 相似文献999.
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Uma Singh Neetu Ahirwar Anju Kumari Rani Nisha Singh Pushplata Sankhwar Sabuhi Qureshi 《Journal of obstetrics and gynaecology of India》2013,63(4):273-278