全文获取类型
收费全文 | 3941篇 |
免费 | 228篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 75篇 |
妇产科学 | 48篇 |
基础医学 | 483篇 |
口腔科学 | 144篇 |
临床医学 | 334篇 |
内科学 | 937篇 |
皮肤病学 | 36篇 |
神经病学 | 552篇 |
特种医学 | 157篇 |
外科学 | 556篇 |
综合类 | 18篇 |
一般理论 | 2篇 |
预防医学 | 188篇 |
眼科学 | 64篇 |
药学 | 195篇 |
中国医学 | 7篇 |
肿瘤学 | 370篇 |
出版年
2023年 | 39篇 |
2022年 | 62篇 |
2021年 | 106篇 |
2020年 | 85篇 |
2019年 | 91篇 |
2018年 | 108篇 |
2017年 | 76篇 |
2016年 | 114篇 |
2015年 | 131篇 |
2014年 | 162篇 |
2013年 | 230篇 |
2012年 | 285篇 |
2011年 | 289篇 |
2010年 | 153篇 |
2009年 | 148篇 |
2008年 | 208篇 |
2007年 | 258篇 |
2006年 | 206篇 |
2005年 | 207篇 |
2004年 | 166篇 |
2003年 | 161篇 |
2002年 | 145篇 |
2001年 | 27篇 |
2000年 | 16篇 |
1999年 | 22篇 |
1998年 | 55篇 |
1997年 | 28篇 |
1996年 | 40篇 |
1995年 | 24篇 |
1994年 | 36篇 |
1993年 | 43篇 |
1992年 | 16篇 |
1991年 | 17篇 |
1990年 | 16篇 |
1989年 | 13篇 |
1988年 | 20篇 |
1987年 | 17篇 |
1986年 | 19篇 |
1985年 | 18篇 |
1984年 | 18篇 |
1983年 | 17篇 |
1982年 | 30篇 |
1981年 | 21篇 |
1980年 | 16篇 |
1979年 | 15篇 |
1978年 | 13篇 |
1977年 | 18篇 |
1976年 | 19篇 |
1974年 | 14篇 |
1970年 | 12篇 |
排序方式: 共有4185条查询结果,搜索用时 14 毫秒
71.
72.
73.
Nils Bomer Niels Grote Beverborg Martijn F. Hoes Koen W. Streng Mathilde Vermeer Martin M. Dokter Jan IJmker Stefan D. Anker John G.F. Cleland Hans L. Hillege Chim C. Lang Leong L. Ng Nilesh J. Samani Jasper Tromp Dirk J. van Veldhuisen Daan J. Touw Adriaan A. Voors Peter van der Meer 《European journal of heart failure》2020,22(8):1415-1423
74.
Nils Schweingruber Henrike J. Fischer Lisa Fischer Jens van den Brandt Anna Karabinskaya Verena Labi Andreas Villunger Benedikt Kretzschmar Peter Huppke Mikael Simons Jan P. Tuckermann Alexander Flügel Fred Lühder Holger M. Reichardt 《Acta neuropathologica》2014,127(5):713-729
Glucocorticoids (GCs) are the standard therapy for treating multiple sclerosis (MS) patients suffering from an acute relapse. One of the main mechanisms of GC action is held to be the induction of T cell apoptosis leading to reduced lymphocyte infiltration into the CNS, yet our analysis of experimental autoimmune encephalomyelitis (EAE) in three different strains of genetically manipulated mice has revealed that the induction of T cell apoptosis is not essential for the therapeutic efficacy of GCs. Instead, we identified the redirection of T cell migration in response to chemokines as a new therapeutic principle of GC action. GCs inhibited the migration of T cells towards CCL19 while they enhanced their responsiveness towards CXCL12. Importantly, blocking CXCR4 signaling in vivo by applying Plerixafor® strongly impaired the capacity of GCs to interfere with EAE, as revealed by an aggravated disease course, more pronounced CNS infiltration and a more dispersed distribution of the infiltrating T cells throughout the parenchyma. Our observation that T cells lacking the GC receptor were refractory to CXCL12 further underscores the importance of this pathway for the treatment of EAE by GCs. Importantly, methylprednisolone pulse therapy strongly increased the capacity of peripheral blood T cells from MS patients of different subtypes to migrate towards CXCL12. This indicates that modulation of T cell migration is an important mechanistic principle responsible for the efficacy of high-dose GC therapy not only of EAE but also of MS. 相似文献
75.
76.
Krone N Reisch N Idkowiak J Dhir V Ivison HE Hughes BA Rose IT O'Neil DM Vijzelaar R Smith MJ MacDonald F Cole TR Adolphs N Barton JS Blair EM Braddock SR Collins F Cragun DL Dattani MT Day R Dougan S Feist M Gottschalk ME Gregory JW Haim M Harrison R Olney AH Hauffa BP Hindmarsh PC Hopkin RJ Jira PE Kempers M Kerstens MN Khalifa MM Köhler B Maiter D Nielsen S O'Riordan SM Roth CL Shane KP Silink M Stikkelbroeck NM Sweeney E Szarras-Czapnik M Waterson JR Williamson L Hartmann MF Taylor NF 《The Journal of clinical endocrinology and metabolism》2012,97(2):E257-E267
77.
Anon E Serra-Picamal X Hersen P Gauthier NC Sheetz MP Trepat X Ladoux B 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(27):10891-10896
Fundamental biological processes such as morphogenesis and wound healing involve the closure of epithelial gaps. Epithelial gap closure is commonly attributed either to the purse-string contraction of an intercellular actomyosin cable or to active cell migration, but the relative contribution of these two mechanisms remains unknown. Here we present a model experiment to systematically study epithelial closure in the absence of cell injury. We developed a pillar stencil approach to create well-defined gaps in terms of size and shape within an epithelial cell monolayer. Upon pillar removal, cells actively respond to the newly accessible free space by extending lamellipodia and migrating into the gap. The decrease of gap area over time is strikingly linear and shows two different regimes depending on the size of the gap. In large gaps, closure is dominated by lamellipodium-mediated cell migration. By contrast, closure of gaps smaller than 20 μm was affected by cell density and progressed independently of Rac, myosin light chain kinase, and Rho kinase, suggesting a passive physical mechanism. By changing the shape of the gap, we observed that low-curvature areas favored the appearance of lamellipodia, promoting faster closure. Altogether, our results reveal that the closure of epithelial gaps in the absence of cell injury is governed by the collective migration of cells through the activation of lamellipodium protrusion. 相似文献
78.
79.
Mainigi SK Almuti K Figueredo VM Guttenplan NA Aouthmany A Smukler J Sheeron B Meldrum B Saenz AD Tran G Greenspan AM 《The American journal of cardiology》2012,109(2):231-237
Inappropriate implantable cardioverter-defibrillator (ICD) therapies can lead to significant adverse events and increased mortality. These therapies are often the result of supraventricular tachycardias (SVTs). The objective of this study was to evaluate the incidence of SVT leading to inappropriate shocks in a large cohort of patients with ICDs and assess the efficacy of radiofrequency ablation (RFA) in decreasing these therapies. Patients with ICDs and recurrent SVTs were identified. A cohort of patients with ICD therapies subsequently underwent electrophysiologic study and RFA. Eighty-four patients (13%) were found to have SVT leading to 122 inappropriate ICD shocks and 130 episodes of antitachycardia pacing therapies. Median time to SVT onset after ICD implantation was 269 days. Electrophysiologic studies were performed in 30 patients. Successful RFA was performed for atrial tachycardia, atrial flutter, or atrioventricular nodal reentrant tachycardia in 22 patients. Ninety-five percent of patients who underwent successful SVT ablation had no further inappropriate ICD therapies compared to 63% of patients in whom ablation was not performed during a mean follow-up of 20.7 ± 11.9 months. In conclusion, SVT is responsible for a significant number of inappropriate ICD therapies. RFA is an effective strategy to substantially decrease subsequent inappropriate ICD therapies. 相似文献
80.
Nils Henninger Diogo C. Haussen Nikolaos Kakouros Magdy Selim D. Eric Searls Sandeep Kumar Gottfried Schlaug Louis R. Caplan 《Neurocritical care》2013,19(2):167-175