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排序方式: 共有795条查询结果,搜索用时 15 毫秒
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Alexander E. Miroslavov Nikolay I. Gorshkov Alexander L. Lumpov Anatoly N. Yalfimov Dmitrii N. Suglobov Beverley L. Ellis Rattana Braddock Anne-Marie Smith Mary C. Prescott Richard S. Lawson Harbans L. Sharma 《Nuclear medicine and biology》2009,36(1):73-79
IntroductionThe use of 99mTc-macroggregated albumin for lung perfusion imaging is well established in nuclear medicine. However, there have been safety concerns over the use of blood-derived products because of potential contamination by infective agents, for example, Variant Creutzfeldt Jakob Disease. Preliminary work has indicated that Tc(CO)5I is primarily taken up in the lungs following intravenous administration. The aim of this study was to evaluate the biodistribution and pharmacokinetics of 99mTc(CO)5I and its potential as a lung perfusion agent.Methods99mTc(CO)5I was synthesized by carbonylation of 99mTcO4? at 160 atm of CO at 170°C in the presence of HI for 40 min. Radiochemical purity was determined by HPLC using 99Tc(CO)5I as a reference. 99mTc(CO)5I was administered by ear-vein injection to three chinchilla rabbits, and dynamic images were acquired using a gamma camera (Siemens E-cam) over 20 min. Imaging studies were also performed with 99mTc-labeled macroaggregated albumin (99mTc-MAA) and 99mTcO4? for comparison. 99mTc(CO)5I was administered intravenously to Sprague–Dawley rats, and tissue distribution studies were obtained at 15 min and 1 h postinjection. Comparative studies were performed using 99mTc-MAA.ResultsRadiochemical purity, assessed by HPLC, was 98%. The retention time was similar to that of 99Tc(CO)5I. The dynamic images showed that 70% of 99mTc(CO)5I appeared promptly in the lungs and remained constant for at least 20 min. In contrast, 99mTcO4? rapidly washed out of the lungs after administration. As expected 99mTc-MAA showed 90% lung accumulation. The percentage of injected dose per gram of organ ±S.D. at 1 h for 99mTc(CO)5I was as follows: blood, 0.22±0.02; lung, 12.8±2.87; liver, 0.8±0.15; heart, 0.15±0.01; kidney, 0.47±0.08. The percentage of injected dose per organ ±S.D. at 1 h was as follows: lung, 22.47±2.31; liver, 10.53±1.8; heart, 0.18±0.01; kidney, 1.2±0.17. Tissue distribution studies with 99mTc-MAA showed 100% lung uptake.Conclusion99mTc(CO)5I was synthesized with a high radiochemical purity and showed a high accumulation in the lungs. Further work on the mechanism and optimization of lung uptake of 99mTc-pentacarbonyl complexes is warranted. 相似文献
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Maria Radanova Galya Mihaylova Zhasmina Mihaylova Desislava Ivanova Oskan Tasinov Neshe Nazifova-Tasinova Pavel Pavlov Milko Mirchev Nikolay Conev Ivan Donev 《Current oncology (Toronto, Ont.)》2021,28(2):1204
The present study evaluated the prognostic role of circulating miRNA-618 in patients with metastatic colon cancer (mCC) and whether miR-618 gene rs2682818 single nucleotide polymorphisms (SNP) are associated with colon cancer susceptibility and expression levels of mature miR-618. In total, 104 patients with mCC before starting the chemotherapy were investigated. The expression status of circulating miR-618 in mCC was evaluated by quantitative PCR. TaqMan PCR assay was used for rs2682818 SNP genotyping. miR-618 was overexpressed in serum of mCC patients. Patients with high and intermediate expression of miR-618 had a significantly longer mean overall survival (OS) of 21 months than patients with low expression—16 months. In addition, multivariate Cox regression analysis confirmed the association between high/intermediate levels of miRNA-618 and longer OS, HR = 0.51, 95% CI: 0.30–0.86, p = 0.012. miR-618 rs2682818 SNP significantly decreased the risk of colon cancer susceptibility in both heterozygous codominant (AC vs. CC, OR = 0.39, 95% CI: 0.17–0.88, p = 0.024) and overdominant (AC vs. CC + AA, OR = 0.37, 95% CI: 0.16–0.85, p = 0.018) genetic models. Our data suggest that circulating miRNA-618 could be useful as a prognostic biomarker in mCC. Patients harboring AC rs2682818 genotype have a decreased risk for colon cancer in comparison with patients with CC and AA genotypes. 相似文献
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Toychiev Abdurakhim Abdujapparov Sulayman Imamov Alim Navruzov Behzod Davis Nikolay Badalova Najiya Osipova Svetlana 《Parasitology research》2018,117(12):3715-3723
Parasitology Research - The purpose of the present study was to determine the prevalence of intestinal helminths and protozoa in colorectal cancer (CRC) patients and to evaluate the possible... 相似文献
85.
Satoshi Watanabe Nikolay S. Markov Ziyan Lu Raul Piseaux Aillon Saul Soberanes Constance E. Runyan Ziyou Ren Rogan A. Grant Mariana Maciel Hiam Abdala-Valencia Yuliya Politanska Kiwon Nam Lango Sichizya Hermon G. Kihshen Nikita Joshi Alexandra C. McQuattie-Pimentel Katherine A. Gruner Manu Jain Jacob I. Sznajder Richard I. Morimoto Paul A. Reyfman Cara J. Gottardi G. R. Scott Budinger Alexander V. Misharin 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(20)
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Nataliya Babyshkina Sergey Vtorushin Marina Zavyalova Stanislav Patalyak Tatyana Dronova Nikolay Litviakov Elena Slonimskaya Julia Kzhyshkowska Nadejda Cherdyntseva Evgeny Choynzonov 《Clinical and experimental medicine》2017,17(3):383-393
Identification of additional biomarkers associated with ER genomic and nongenomic pathways could be very useful to distinguish patients who will benefit from tamoxifen treatment. The aim of this study was to analyze the prognostic significance of the distribution pattern of ERα expression, ESR1 gene single-nucleotide polymorphisms and expression levels of growth factor receptors in Russian hormone receptor-positive breast cancer patients treated with adjuvant tamoxifen. Formalin-fixed paraffin-embedded tumor tissue samples from 97 patients were examined for the distribution pattern of ERα expression, as well as for EGFR and TGF-βR1 expression by immunohistochemistry. Genotypes for ESR1 +30T>C (rs2077647) and ESR1 2014G>A (rs2228480) were analyzed using a TaqMan assay. Progression-free survival (PFS) was used as an endpoint for the survival analyses. We found that patients with the heterogeneous distribution of ERα expression had poor prognosis on tamoxifen treatment (P = 0.021). We identified a high EGFR expression in patients who developed distant metastasis or recurrence during tamoxifen treatment (a tamoxifen-resistant group—TR) in contrast to the distant metastasis-free patients (a tamoxifen-sensitive group—TS) (80.0 vs. 41.9 %, respectively, P = 0.009). Carriers of the ESR12014A mutant allele were more prevalent among the TR patients compared to the TS patients (26.3 vs. 8.0 %, respectively, P = 0.009). EGFR expression and the distribution pattern of ERα expression were associated with the response to tamoxifen by both univariate and multivariate logistic regression analyses. The presence of these markers either alone or in combination was correlated with the worse PFS for all patients. Analysis of the distribution pattern of ERα expression and the EGFR status in tumor tissue may be valuable for patient selection for tamoxifen adjuvant therapy. 相似文献