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Liubov Glukhova Anne-Franoise Goguel Ilse Chudoba Eric Angevin Christine Pavon Marie-Jos Terrier-Lacombe Mounira Meddeb Bernard Escudier Alain Bernheim 《Genes, chromosomes & cancer》1998,22(3):171-178
Xenografts from four metastatic renal cell carcinomas (RCCs) were established in immunodeficient mice. All tumors exhibited cytogenetic features specific for the papillary subtype, namely, partial or total polysomy of chromosomes 7 and 17 and integrity of 3p. Cytogenetic analysis of the initial and xenografted tumors indicated that although clonal characteristics were consistently maintained in xenografts derived from metastases, a minor clone had been selected for in the xenografts derived from the primary tumors. Reverse painting and comparative genomic hybridization (CGH) allowed us to localize minimal overrepresented genomic regions to 7q31, where the MET protooncogene is located, and to 17q. Other overrepresented regions were 8q in all xenografts and Xq22–qter in three of them. The gain of genetic material from these regions may be a key factor ensuring the papillary nature of RCCs and their survival in xenografts. Genes Chromosomes Cancer 22:171–178, 1998. © 1998 Wiley-Liss, Inc. 相似文献
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Souabni L Meddeb N Ajlani H Ben Romdhane N Sellami S 《Joint, bone, spine : revue du rhumatisme》2008,75(3):348-349
Congenital factor XI deficiency (also known as the Rosenthal syndrome or hemophilia C) manifests as minor bleeding, usually after trauma or surgery. We report a case in which bilateral knee hemarthrosis was the first manifestation. The patient presented at 32 years of age with a 2-year history of mechanical pain and intermittent swelling in both knees. Knee aspiration recovered blood-tinged fluid. The laboratory workup showed severe factor XI deficiency. Replacement therapy with fresh frozen plasma was effective. Tests in the family showed factor XI deficiency in the patient's sister. 相似文献
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Zaraa I Labbène I Trojjet S Mrabet D Meddeb N Chelly I Haouet S Mokni M Sellami S Ben Osman A 《Journal of cutaneous medicine and surgery》2012,16(5):357-360
Background:Endogenous ochronosis (EO) is an autosomal recessive inherited disorder where there is incomplete oxidation of tyrosine and phenylalanine due to a lack of the enzyme homogentisic acid oxidase.Objective:We report a singular observation of EO with a fatal outcome.Case Report:We report the case of a 46-year-old man born to consanguineous parents with a medical history of recurrent renal colic and chronic nonspecific arthropathy. On clinical examination, slate blue pigmentation was seen on the cheeks, forehead, and nose, as well as blue-gray patches on all fingernails and bluish discoloration of the gums. Familial investigation revealed that his sister had similar pigmentation on the ears, hands, and fingernails. Histologic examination of a biopsy specimen from a pigmented lesion showed a dermal deposit of an acellular, eosinophilic material without cell reaction. Based on the clinical and histopathologic data, combined with the family medical history, our patient was considered to have EO with mucocutaneous, articular, and renal involvement. Unfortunately, the diagnosis was late because our patient died a few months later of terminal renal failure.Conclusion:Skin signs are the hallmarks of EO and must alert the clinician to look for involvement of vital organs. 相似文献
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Hafsia R Marrakchi O Ben Salah N Gouider E Ben Lakhal R Jeddi R Aissaoui L Belhadjali Z Ben Abid H Meddeb B Hafsia A 《La Tunisie médicale》2007,85(3):209-211
AIM: was to provide the clinical and biological patterns hemoglobine disease in Tunisia. METHODS: This retrospective study collected to 16 cases of hemoglobin C disease : 6 homozygotic Hb C and 10 heterozygotic Hb C/beta-thalassemia. RESULTS: The clinical profile is characterized by mild hemolytic anemia (Hb = 11.7 g/dl) associated with splenomegaly and hypersplenism. Contrary to homozygous state, the Hb C/beta-thalassemia is associated with microcytosis and pseudopolycythemia. The diagnosis is based on target cells, specific intraerythrocytic Hb C crystals in blood smear and Hb C level at 100%. CONCLUSION: The Hb C disease must be considered as a benign hemoglobinopathy which is associated with a long survival without major complications. 相似文献
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