全文获取类型
收费全文 | 1993篇 |
免费 | 103篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 55篇 |
妇产科学 | 77篇 |
基础医学 | 295篇 |
口腔科学 | 38篇 |
临床医学 | 139篇 |
内科学 | 510篇 |
皮肤病学 | 67篇 |
神经病学 | 223篇 |
特种医学 | 59篇 |
外科学 | 121篇 |
综合类 | 10篇 |
预防医学 | 76篇 |
眼科学 | 13篇 |
药学 | 190篇 |
中国医学 | 1篇 |
肿瘤学 | 222篇 |
出版年
2023年 | 15篇 |
2022年 | 33篇 |
2021年 | 61篇 |
2020年 | 31篇 |
2019年 | 46篇 |
2018年 | 50篇 |
2017年 | 37篇 |
2016年 | 66篇 |
2015年 | 47篇 |
2014年 | 68篇 |
2013年 | 81篇 |
2012年 | 140篇 |
2011年 | 162篇 |
2010年 | 91篇 |
2009年 | 86篇 |
2008年 | 130篇 |
2007年 | 159篇 |
2006年 | 153篇 |
2005年 | 127篇 |
2004年 | 114篇 |
2003年 | 113篇 |
2002年 | 99篇 |
2001年 | 13篇 |
2000年 | 8篇 |
1999年 | 16篇 |
1998年 | 17篇 |
1997年 | 23篇 |
1996年 | 11篇 |
1995年 | 16篇 |
1994年 | 19篇 |
1993年 | 15篇 |
1992年 | 4篇 |
1991年 | 7篇 |
1990年 | 4篇 |
1989年 | 6篇 |
1988年 | 7篇 |
1985年 | 3篇 |
1984年 | 3篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1972年 | 1篇 |
1965年 | 1篇 |
1964年 | 1篇 |
排序方式: 共有2102条查询结果,搜索用时 11 毫秒
31.
Briana DD Boutsikou M Gourgiotis D Kontara L Baka S Iacovidou N Hassiakos D Malamitsi-Puchner A 《Journal of perinatal medicine》2007,35(4):326-329
OBJECTIVE: IGF-I and insulin are the main regulators of intrauterine and postnatal growth. Adipose tissue secreted cytokines are implicated in intrauterine growth. The relevant function of the adipocytokine visfatin is unknown. MATERIALS AND METHODS: Serum visfatin, IGF-I and insulin levels were measured by enzyme immunoassays in 40 singleton full-term fetuses and neonates on postnatal days 1(N1) and 4 (N4). RESULTS: No significant correlations exist between visfatin and IGF-I or insulin. N1 and N4 visfatin positively correlated with customized (adjusted) birth weight centiles (r=0.511, P=0.021, and r=0.597, P=0.005, respectively). Fetal and N1 IGF-I positively correlated with customized centiles (r=0.608, P<0.001 and r=0.485, P=0.006, respectively). Fetal insulin positively correlated with customized centiles (r=0.654, P=0.021). CONCLUSIONS: Potential implication of visfatin in fetal growth is probably not mediated by IGF-I or insulin. Although a more active role cannot be excluded, visfatin may simply represent a marker of fat accumulation. 相似文献
32.
Campisi G Panzarella V Termine N Giovannelli L 《European journal of obstetrics, gynecology, and reproductive biology》2007,130(1):142-3; author reply 143
33.
Vanesa Pérez-Martínez Belén Sanz-Barbero Rosario Ferrer-Cascales Nicola Bowes Alba Ayala Miriam Sánchez-SanSegundo Natalia Albaladejo-Blázquez Nicoletta Rosati Sofia Neves Cristina Pereira Vieira Barbara Jankowiak Katarzyna Waszyńska Carmen Vives-Cases 《The Journal of adolescent health》2021,68(5):922-929
PurposeTo analyze the potential association between social support, experiences of violence, and sociodemographic characteristics of adolescents and the likelihood of acceptance of violence and machismo in different European countries.MethodsCross-sectional design. We recruited 1,555 participants ages 13–16 from secondary schools in Alicante (Spain), Rome (Italy), Iasi (Romania), Matosinhos (Portugal), Poznan (Poland), and Cardiff (UK). We used linear regression models to identify how social support from teachers and parents, experiences of violence—dating violence, bullying, cyberbullying, abuse in childhood—and sociodemographic characteristics were associated with violent thinking, specifically: machismo and acceptance of violence. The analysis was stratified by sex.ResultsAcceptance of violence was higher for those who had lower perceived social support from parents (βgirls = ?154, p < .001; βboys = ?.114, p = .019) for both sexes. Perpetration of bullying and/or cyberbullying was associated with higher scores for machismo and acceptance of violence for both sexes (βgirls = .067, p = .035; βboys = .225, p < .001; (βgirls = .118, p < .001; βboys = .210, p < .001). Being the victim of dating violence, having suffered physical and/or sexual abuse in childhood, and lower perceived social support from teachers were associated with higher scores for both machismo and acceptance of violence. These associations differed between girls and boys.ConclusionsMachismo and acceptance of violence are widely present amongst adolescents in different European countries. Our results suggest the importance of providing educational/psycho-educational interventions with boys and girls to prevent these attitudes and, in turn, prevent interpersonal violence, including bullying and dating violence. 相似文献
34.
35.
Filippo Monelli Francesco Venturelli Lisa Bonilauri Elisa Manicardi Valeria Manicardi Paolo Giorgi Rossi Marco Massari Guido Ligabue Nicoletta Riva Susanna Schianchi Efrem Bonelli Pierpaolo Pattacini Maria Chiara Bassi Giulia Besutti 《肝癌研究(英文版)》2021,7(4):13-24
Aim: In this systematic review, guidelines on non-alcoholic fatty liver disease (NAFLD) were evaluated, aiming at a guideline synthesis focusing on diagnosis an... 相似文献
36.
Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia 下载免费PDF全文
37.
Drousiotou A Touma EH Andreou N Loiselet J Angastiniotis M Verrelli BC Tishkoff SA 《Blood cells, molecules & diseases》2004,33(1):25-30
In the present study, we determined the frequency of glucose-6-phosphate dehydrogenase (G6PD) deficiency in Cyprus using two different procedures in two separate adult population groups: a semiquantitative fluorescence test on blood spotted on filter paper and a quantitative spectrophotometric test on liquid blood. The frequency of G6PD deficiency among healthy adult males was found to be 5.1% using the semiquantitative procedure and 6.4% using the quantitative procedure. Neither method was able to detect all the expected female heterozygotes (5.3% and 47.1% of the expected number, respectively). A total of 21 male hemizygotes, 1 female homozygote and 9 female heterozygotes that tested positive for G6PD deficiency were studied at the molecular level. All 32 chromosomes were genotyped and five different mutations were identified. The Mediterranean mutation in exon 6 (563C-->T) (Ser188Phe) was found to be the most common variant in the Cypriot population, accounting for 52.6% of the deficient alleles. In the remaining chromosomes, four different mutations were identified: three known mutations, Kaiping 1388G-->A (Arg463His), Chatham 1003G-->A (Ala335Thr) and Acrokorinthos 463C-->G (His155Asp), and one previously undescribed mutation in exon 3, 148C-->T (Pro50Ser), which we called G6PD Kambos. We conclude that the frequency of G6PD deficiency in Cypriot males is 6.4%, and that this deficiency is the result of several different mutations. Although all the individuals carrying the Mediterranean variant can be detected using a semiquantitative screening method, a quantitative enzyme measurement is required to detect the G6PD variants with less severe enzyme deficiencies, while the most appropriate method for heterozygote detection is DNA analysis. 相似文献
38.
Russo D Malagola M de Vivo A Fiacchini M Martinelli G Piccaluga PP Damiani D Candoni A Michielutti A Castelli M Testoni N Ottaviani E Rondoni M Pricolo G Mazza P Zuffa E Zaccaria A Raspadori D Bocchia M Lauria F Bonini A Avanzini P Gugliotta L Visani G Fanin R Baccarani M 《British journal of haematology》2005,131(2):172-179
Fludarabine plus cytarabine (Ara-C) and idarubicin (FLAI) is an effective and well-tolerated induction regimen for the treatment of acute myeloid leukaemia (AML). This phase III trial compared the efficacy and toxicity of FLAI versus idarubicin plus Ara-C and etoposide (ICE) in 112 newly diagnosed AML patients <60 years. Fifty-seven patients received FLAI, as the first induction-remission course, and 55 patients received ICE. Post-induction treatment consisted of high-dose Ara-C (HDAC). After HDAC, patients in complete remission (CR) received a second consolidation course (mitoxantrone, etoposide, Ara-C) and autologous stem cell transplantation (auto-SCT) or allogeneic (allo)-SCT, according to the age, disease risk and donor availability. After a single induction course, CR rate was 74% in the FLAI arm and 51% in the ICE arm (P = 0.01), while death during induction was 2% and 9% respectively. Both haematological (P = 0.002) and non-haematological (P = 0.0001) toxicities, especially gastrointestinal (i.e. nausea, vomiting, mucositis and diarrhoea), were significantly lower in FLAI arm. In both arms, relapses were more frequent in patients who were not submitted to allo-SCT. After a median follow-up of 17 months, 30% and 38% of the patients are in continuous CR in FLAI and ICE arm respectively. Our prospective randomised study confirmed the anti-leukaemic effect and the low toxic profile of FLAI as induction treatment for newly diagnosed AML patients. 相似文献
39.
Ji Yun Song Puya Aravand Sergei Nikonov Lanfranco Leo Arkady Lyubarsky Jeannette L. Bennicelli Jieyan Pan Zhangyong Wei Ivan Shpylchak Pamela Herrera Daniel J. Bennett Nicoletta Commins Albert M. Maguire Jennifer Pham Anneke I. den Hollander Frans P.M. Cremers Robert K. Koenekoop Ronald Roepman Jean Bennett 《Molecular therapy》2018,26(6):1581-1593
40.
Development and validation of a risk stratification score for new‐onset atrial fibrillation in STEMI patients undergoing primary percutaneous coronary intervention 下载免费PDF全文