全文获取类型
收费全文 | 17978篇 |
免费 | 1110篇 |
国内免费 | 97篇 |
专业分类
耳鼻咽喉 | 125篇 |
儿科学 | 457篇 |
妇产科学 | 410篇 |
基础医学 | 2164篇 |
口腔科学 | 329篇 |
临床医学 | 1749篇 |
内科学 | 4142篇 |
皮肤病学 | 300篇 |
神经病学 | 1960篇 |
特种医学 | 775篇 |
外科学 | 2609篇 |
综合类 | 129篇 |
一般理论 | 6篇 |
预防医学 | 1248篇 |
眼科学 | 399篇 |
药学 | 1039篇 |
中国医学 | 37篇 |
肿瘤学 | 1307篇 |
出版年
2024年 | 24篇 |
2023年 | 199篇 |
2022年 | 304篇 |
2021年 | 539篇 |
2020年 | 405篇 |
2019年 | 493篇 |
2018年 | 561篇 |
2017年 | 437篇 |
2016年 | 562篇 |
2015年 | 537篇 |
2014年 | 744篇 |
2013年 | 934篇 |
2012年 | 1519篇 |
2011年 | 1524篇 |
2010年 | 825篇 |
2009年 | 693篇 |
2008年 | 1209篇 |
2007年 | 1165篇 |
2006年 | 1022篇 |
2005年 | 1051篇 |
2004年 | 941篇 |
2003年 | 816篇 |
2002年 | 759篇 |
2001年 | 133篇 |
2000年 | 108篇 |
1999年 | 157篇 |
1998年 | 156篇 |
1997年 | 87篇 |
1996年 | 107篇 |
1995年 | 90篇 |
1994年 | 68篇 |
1993年 | 72篇 |
1992年 | 78篇 |
1991年 | 66篇 |
1990年 | 40篇 |
1989年 | 57篇 |
1988年 | 55篇 |
1987年 | 43篇 |
1986年 | 43篇 |
1985年 | 56篇 |
1984年 | 38篇 |
1983年 | 48篇 |
1982年 | 42篇 |
1981年 | 34篇 |
1980年 | 30篇 |
1979年 | 24篇 |
1972年 | 21篇 |
1971年 | 26篇 |
1970年 | 24篇 |
1968年 | 27篇 |
排序方式: 共有10000条查询结果,搜索用时 14 毫秒
91.
Kang JH Farina A Park JH Kim SH Kim JY Rizzo N Elmakky A Jun HS Hahn WB Cha DH 《Prenatal diagnosis》2008,28(8):704-709
OBJECTIVES: To estimate the combined screening performance of first and early second trimester prenatal serum markers for Down syndrome, in screening for the development of preeclampsia, and analyze the correlation among marker levels, week of onset, and severity of the disease. METHODS: A retrospective cohort study was carried out on 32 women with preeclampsia and 3044 controls. Serum samples from these pregnancies were assayed for pregnancy-associated plasma protein-A (PAPP-A), alpha-fetoprotein (AFP), unconjugated estriol (uE3), human chorionic gonadotrophin (hCG), and inhibin-A. A likelihood ratio and the odds of being affected given a positive result (OAPR) of various combinations of markers were calculated and receiver operating characteristic (ROC) curves analysis was performed. RESULTS: In the pregnancies that subsequently developed preeclampsia, first trimester PAPP-A concentration was significantly lower and concentrations of early second trimester inhibin-A and hCG significantly elevated. Levels of early second trimester uE3 and AFP were not significantly altered. We also found that inhibin-A correlates with both onset of the disease and the severity. CONCLUSION: Down syndrome biochemical markers levels are altered in those patients who subsequently developed preeclampsia and may be a useful screening test for preeclampsia. Inhibin-A is the most predictive marker and correlates with the severity of subsequent preeclampsia and inversely with the week of occurrence of preeclampsia. 相似文献
92.
93.
Zampieri N Borruto F Zamboni C Camoglio FS 《Archives of gynecology and obstetrics》2008,277(4):303-306
Background Abdominal cystic formations in newborns are relatively common and often diagnostic suspicion arises in this regard even before
birth as a result of ultrasound scans carried out during pregnancy. The aim of this study is to highlight the problems posed
by the prenatal diagnosis of abdominal cysts in order to outline the most appropriate therapeutic approach in case of suspected
ovarian cysts.
Materials and methods Between January 2003 and January 2007, 57 women were enrolled in this study for a prenatal ultrasound (US) that revealed the
presence of an echo-rare or echo-free area in the foetal abdomen. After birth all babies underwent blood tests and abdominal
US scans in order to confirm or identify the nature of the cyst. If abdominal US could not show the nature of the cystic formation,
magnetic resonance imaging with sedation was performed. When the radiological tests were not useful to identify the nature
of the cysts and surgery was then necessary, surgical procedures were performed with laparoscopy.
Results Ultrasounds were useful to identify the diameter of the cysts but not all their origins; also MRI confirmed the morphology
and volume of the cysts, but could not give further details about their origin.
Discussion Abdominal ultrasound and finally laparoscopy used to treat and remove the cysts were useful to monitor all simple abdominal
cysts. MRI seemed not to be useful for the treatment of this condition, especially in the pediatric age when mild sedation
is required. 相似文献
94.
95.
Deep dyspareunia: causes, treatments, and results 总被引:1,自引:0,他引:1
PURPOSE OF REVIEW: We critically review the causes and treatments of deep dyspareunia. RECENT FINDINGS: Endometriosis, pelvic congestion syndrome, and interstitial cystitis have been associated with deep dyspareunia. Although medical therapies may improve deep dyspareunia in women with endometriosis, laparoscopic excision of deep endometriotic lesions has been demonstrated to improve not only deep dyspareunia but also the quality of sex life. Deep dyspareunia related to the presence of pelvic congestion syndrome should be treated by pelvic vein embolization. Intravesical therapy may be effective in treating deep dyspareunia in women with interstitial cystitis. It remains unclear whether uterine myomas and adenomyosis are causes of deep dyspareunia. SUMMARY: Treatment of deep dyspareunia should be mainly directed to causative factors; however, clinicians should keep in mind that secondary sexual dysfunction can arise from organic pelvic pathology. 相似文献
96.
97.
Pretta S Remorgida V Abbamonte LH Anserini P Ragni N Del Sette M Gandolfo C Ferrero S 《European journal of obstetrics, gynecology, and reproductive biology》2007,132(2):226-231
OBJECTIVE: This study aims to determine whether women with endometriosis have greater subclinical atherosclerosis than the general population. STUDY DESIGN: This case-control study included 66 women with endometriosis and 66 controls matched for age and body mass index. All subjects were >or=35 years old. Exclusion criteria were obesity, diabetes, hypertension, hyperlipidemia, renal or metabolic diseases. Before laparoscopy, all patients underwent a measurement of intima-media thickness (IMT) and distensibility coefficient (DC) on the common carotid artery. In addition, blood samples were taken to determine the levels of lipids, fibrinogen, C-reactive protein, homocysteine, fasting glycemia, antithrombin III, plasminogen, protein C, protein S, and activated protein C resistance. RESULTS: All the biochemical parameters evaluated had similar levels in the two study groups. IMT was similar in women with endometriosis and in controls both on left (p=0.330) and right (p=0.648) carotid artery. Similarly, no significant difference was observed in the DC between women with endometriosis and controls both on left (p=0.539) and right (p=0.178) carotid artery. No significant difference was observed in IMT and DC between women with mild and severe endometriosis. CONCLUSION: Women with endometriosis do not have more subclinical atherosclerosis than the general population. 相似文献
98.
99.
Vanesa Pérez-Martínez Belén Sanz-Barbero Rosario Ferrer-Cascales Nicola Bowes Alba Ayala Miriam Sánchez-SanSegundo Natalia Albaladejo-Blázquez Nicoletta Rosati Sofia Neves Cristina Pereira Vieira Barbara Jankowiak Katarzyna Waszyńska Carmen Vives-Cases 《The Journal of adolescent health》2021,68(5):922-929
PurposeTo analyze the potential association between social support, experiences of violence, and sociodemographic characteristics of adolescents and the likelihood of acceptance of violence and machismo in different European countries.MethodsCross-sectional design. We recruited 1,555 participants ages 13–16 from secondary schools in Alicante (Spain), Rome (Italy), Iasi (Romania), Matosinhos (Portugal), Poznan (Poland), and Cardiff (UK). We used linear regression models to identify how social support from teachers and parents, experiences of violence—dating violence, bullying, cyberbullying, abuse in childhood—and sociodemographic characteristics were associated with violent thinking, specifically: machismo and acceptance of violence. The analysis was stratified by sex.ResultsAcceptance of violence was higher for those who had lower perceived social support from parents (βgirls = ?154, p < .001; βboys = ?.114, p = .019) for both sexes. Perpetration of bullying and/or cyberbullying was associated with higher scores for machismo and acceptance of violence for both sexes (βgirls = .067, p = .035; βboys = .225, p < .001; (βgirls = .118, p < .001; βboys = .210, p < .001). Being the victim of dating violence, having suffered physical and/or sexual abuse in childhood, and lower perceived social support from teachers were associated with higher scores for both machismo and acceptance of violence. These associations differed between girls and boys.ConclusionsMachismo and acceptance of violence are widely present amongst adolescents in different European countries. Our results suggest the importance of providing educational/psycho-educational interventions with boys and girls to prevent these attitudes and, in turn, prevent interpersonal violence, including bullying and dating violence. 相似文献
100.
Emmanuel de Billy Marsha Pellegrino Domenico Orlando Giulia Pericoli Roberta Ferretti Pietro Businaro Maria Antonietta Ajmone-Cat Sabrina Rossi Lucia Lisa Petrilli Nicola Maestro Francesca Diomedi-Camassei Marco Pezzullo Cristiano De Stefanis Paola Bencivenga Alessia Palma Rossella Rota Francesca Del Bufalo Luca Massimi Gerrit Weber Chris Jones Andrea Carai Simona Caruso Biagio De Angelis Ignazio Caruana Concetta Quintarelli Angela Mastronuzzi Franco Locatelli Maria Vinci 《Neuro-oncology》2022,24(7):1150
BackgroundDiffuse midline gliomas (DMG) H3K27M-mutant, including diffuse intrinsic pontine glioma (DIPG), are pediatric brain tumors associated with grim prognosis. Although GD2-CAR T-cells demonstrated significant anti-tumor activity against DMG H3K27M-mutant in vivo, a multimodal approach may be needed to more effectively treat patients. We investigated GD2 expression in DMG/DIPG and other pediatric high-grade gliomas (pHGG) and sought to identify chemical compounds that would enhance GD2-CAR T-cell anti-tumor efficacy.MethodsImmunohistochemistry in tumor tissue samples and immunofluorescence in primary patient-derived cell lines were performed to study GD2 expression. We developed a high-throughput cell-based assay to screen 42 kinase inhibitors in combination with GD2-CAR T-cells. Cell viability, western blots, flow-cytometry, real time PCR experiments, DIPG 3D culture models, and orthotopic xenograft model were applied to investigate the effect of selected compounds on DIPG cell death and CAR T-cell function.ResultsGD2 was heterogeneously, but widely, expressed in the tissue tested, while its expression was homogeneous and restricted to DMG/DIPG H3K27M-mutant cell lines. We identified dual IGF1R/IR antagonists, BMS-754807 and linsitinib, able to inhibit tumor cell viability at concentrations that do not affect CAR T-cells. Linsitinib, but not BMS-754807, decreases activation/exhaustion of GD2-CAR T-cells and increases their central memory profile. The enhanced anti-tumor activity of linsitinib/GD2-CAR T-cell combination was confirmed in DIPG models in vitro, ex vivo, and in vivo.ConclusionOur study supports the development of IGF1R/IR inhibitors to be used in combination with GD2-CAR T-cells for treating patients affected by DMG/DIPG and, potentially, by pHGG. 相似文献