五味消栓口服液治疗脑梗塞临床研究

目的;观察五味消栓口服液治疗脑梗塞的临床疗效,方法：治疗组300例采用五味消栓口服液治疗,每次10ml,每日3次口服,对照组100例采用消栓口服液,每次10ml,每日3次了,均1个月为1疗程,单盲给药,结果：本药总有效率91．33％,愈显率53％,能显著改善中医药临床症状和神经功能缺损,显著改善血流液变学各项观察指标,并且无明显毒副作用,结论：提示五味消栓口服液对脑硬塞确有疗效。     

创伤性窒息脑损害引起的迟发性LTP抑制及L-NNA对其影响

目的：研究创伤性窒息（TA）脑损害后长时程增强（LTP）的变化以及一氧化氮合酶抑制剂L－NNA对它的影响,方法：创伤性窒息后第1天和第3天分记录海马Schaffer侧支－CA1和穿通通路－齿状回突触的群体身电位,结果,在海马侧支－CAI通路,脑损害后第1卫和第3天LTP明显受到抑制,第1天和第3天LTP受抑制程度无明显不同,穿通质－龄状回通路中LTP 在脑损害后第3天受到明显抑制,给予L－NNA(50mg/kgi.p),可显著减轻LTP迟发性的抑制,以上结果表明海马系统的LTP在TA后明显受到损害,海神经元存在一个可称之为“迟发性LTP抑制”的现象,结论：一氧化氮合酶抑制剂L－NNA可减轻LTP的损害和迟发性抑制作用,提示NO参予了迟发性LTP抑制的病理发生机制,且可能与创伤性窒息脑损害后的学习,记忆能力减退有关。     

中度高原脑血管病106例死因分析

本文对中度高原脑血管病的死因进行了回顾性研究分析，结果表明：①一周内死亡者，原因多为原发病引起的脑病（海马钩回疝，小脑扁桃体疝或二者并存）；二周后死亡者，原因多为直接死于并发症或并发症促使病情加重形成脑疝死亡；②死亡年龄以５０～６９岁所占比重最大，男性高于女性。     

癫痫患者脑脊液中3种阿片肽的测定

用放射免疫法测定32例癫痫患者脑脊液中亮-脑啡肽、甲-脑啡肽和β-内啡肽含量,癫痫患者亮-脑啡肽平均含量(91.24±5.54ng/L)显著高于对照组(68.08±4.38ng/L)(P<0.01),甲-脑啡肽与β-内啡肽均无显著性变化。亮-脑啡肽的增高与取脑脊液距末次发作时间、临床发作类型、是否服抗癫痫药物及脑CT检查是否正常等因素无关。提示内源性阿片肽可能参与人类癫痫的神经化学发病机制,亮-脑啡肽是其中的重要物质。     

颞叶内侧型癫癎颅外电极脑电图发作及发作间期可靠性的研究

目的　评价头皮及蝶骨电极脑电图对术前诊断颞叶内侧型癫 (MTLE)的可靠性。方法　回顾性分析在日本国家癫中心行选择性海马、杏仁核切除术的 110例患者中的 39例 ,他们皆为预后Engel分级一级 ,且保持 2年以上的患者。应用日本癫中心的分类方法对这些患者脑电图的术前发作间期放电 (IED)和发作期放电 (ID)进行分类 ,并与手术侧别相比较。结果　所有患者IED均起自蝶骨电极区或颞叶前区。半数患者有双侧IED。除 1例患者外 ,其余患者IED优势侧均与手术侧一致。切除低频度IED侧同样也可获得很好的预后。依照我们的分类方法 ,有 6 4 %的患者脑电图可见不同的发作类型。在 39例患者中 ,37例患者脑电图发作的侧别与手术侧一致。只有两例患者例外 ,但与手术同侧的发作次数占优势。结论　在MTLE患者中 ,发作间期脑电图呈现一侧优势时有定侧意义 ,低频度IED侧并非手术禁忌 ,应结合其他检查综合分析。发作期的头皮脑电图与发作间期相比 ,定侧更为可靠。     

新型钙调素拮抗剂对体外人脑恶性星形细胞瘤细胞增殖的抑制

采用生长曲线、集落形成试验、蛋白含量测定、超微结构检查、流式细胞术及~3H-TdR掺入试验,观察了新型钙调素持抗剂O-4-Z氧基-丁基-小檗胺[O-(4-ethoxyl-butyl),berb-amine,EBB]对TJ861人脑恶性星形细胞瘤体外细胞系增殖的影响,发现EBB抑制这种细胞的增殖。EBB与化疗药BCNU联合应用有协同作用。     

Up-regulation of SEPT7 Gene Inhibits Migration and Invasion of Human Glioma Cells in vitro and in vivo

The aim of this study was to explore the potential role of SEPT7 in glioma cell invasion. From in vitro experiments, we observed that the migratory and invasive abilities were inhibited in human glioblastoma U251MG and TJ899 cells after transfection with SEPT7 recombinant adenovirus constructs (Ad-SEPT7) as evaluated by Transwell assay, 3D Matrigel growth, 2D Matrigel growth and scratch assays. We further investigated the molecular events associated with the alteration of cell migration and invasion by immu...     

Self-reported depression and anti-depressant medication use in essential tremor: cross-sectional and prospective analyses in a population-based study

There are few data on the co-morbidity of essential tremor (ET) with depression. To assess the associations of ET with self-reported depression and antidepressant medication use. In a population-based study in central Spain, participants were evaluated at baseline (1994–1995) and 3 years later. Self-reported depression and use of antidepressant medications were evaluated at each assessment. In cross-sectional analyses, prevalent ET cases were twice more probably than controls to report depression [103 (43.8%) of 235 cases versus 1137 (26.0%) of 4379 controls; adjusted odds ratio (OR) 2.20, 95% confidence interval (CI) 1.66–2.93, P  < 0.001] and three times more probably to be taking antidepressant medications [16 (6.8%) cases versus 113 (2.6%) controls; adjusted OR 3.33, 95% CI 1.91–5.82, P  = 0.001]. In prospective analyses, baseline self-reported depression (adjusted RR 1.78, 95% CI 1.11–2.89, P  = 0.018) and, perhaps, baseline use of antidepressant medication (adjusted RR 1.90, 95% CI 0.59–6.05, P  = 0.28) were associated with incident ET. Rather than being totally benign, ET seems to be associated with a mood disorder. Furthermore, as well as being a secondary response to disease manifestations, this mood disorder may be a primary feature of the underlying disease.     

神经外科危重昏迷患者肠内营养专家共识

重型颅脑创伤、脑肿瘤、脑血管病或颅脑手术可能导致患者昏迷.昏迷患者常出现吞咽困难、神经源性胃肠功能障碍、基础代谢紊乱等严重并发症.昏迷患者由于外源性能量(食物)摄入量明显减少,应激反应导致机体能量消耗增加伴分解代谢增加,血糖大量消耗导致肝糖原和肌糖原加速分解,伤后体内的葡萄糖来源主要由体内蛋白质和脂肪分解后的糖异生过程供给.